Safety and Clinical Efficacy of Dental Materials Quiz
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Questions and Answers

What is the purpose of in vitro assays in dental materials testing?

  • To assess materials at the cellular level (correct)
  • To test materials in small animals
  • To conduct tests on humans directly
  • To evaluate materials using larger animals

    • Which animals are typically used in secondary tests for dental materials?

  • Pigs
  • Monkeys (correct)
  • Dogs
  • Rabbits

    • What determines the number of tests needed in dental materials testing?

  • The geographical location where the tests are conducted
  • The phase of testing and material elimination (correct)
  • The cost of conducting each test
  • The size of the animal used in testing

    • What type of tests are conducted in in vivo usage tests for dental materials?

    <p>Tests for dermal irritation and bony implantation</p> Signup and view all the answers

    Which organization's approval is needed to conduct in vivo usage tests on humans for dental materials?

    <p>Food and Drug Administration (FDA)</p> Signup and view all the answers

    What type of test involves applying materials in animals as they would be applied to a patient?

    <p><em>In Vivo Tests</em></p> Signup and view all the answers

    Which material was found to have the most severe inflammatory reaction?

    <p>The silicate</p> Signup and view all the answers

    What was the reaction level for the composite material?

    <p>Moderate to slight</p> Signup and view all the answers

    Which material had little or no effect?

    <p>The ZOE</p> Signup and view all the answers

    What is the purpose of the references provided in the text?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is NOT mentioned as a key reference in the text?

    <p>Sakaguchi and Powers (2012)</p> Signup and view all the answers

    What is the main focus of the text?

    <p>Comparing the inflammatory reactions of different dental materials</p> Signup and view all the answers

    What is the main purpose of postmarket surveillance?

    <p>To monitor the safety and performance of dental materials after they are introduced to the market</p> Signup and view all the answers

    What do the ISO 7405 and ISO 10993 standards cover?

    <p>Biological evaluation of dental materials and medical devices</p> Signup and view all the answers

    What is the purpose of the four levels of testing described in the ISO 7405 standard?

    <p>To evaluate the cytotoxicity, tissue compatibility, and safety of new dental materials</p> Signup and view all the answers

    What is the primary responsibility of a dental material manufacturer when selecting tests for biological evaluation?

    <p>To select the appropriate tests based on the intended use and known/assumed toxicity of the material</p> Signup and view all the answers

    Why is it important to consider the manufacturer's stated use for the material when evaluating test results?

    <p>To interpret the test results in the context of the material's intended use</p> Signup and view all the answers

    What is the importance of following strict guidelines and humane animal use ethics when conducting in vivo testing on dental materials?

    <p>To minimize the suffering of animals used in the testing</p> Signup and view all the answers

    According to the cell culture tests, which material had the most severe effect on cultured cells?

    <p>ZOE (zinc oxide eugenol) cement</p> Signup and view all the answers

    At the 30-day observation point in the implantation test, which material caused a more severe reaction than silicate cement?

    <p>ZOE (zinc oxide eugenol) cement</p> Signup and view all the answers

    Which statement is true about the inflammatory reactions at 90 days in the implantation test?

    <p>ZOE and silicate caused slight reactions, while resin composite caused a moderate reaction</p> Signup and view all the answers

    In the usage test, where the materials were evaluated in class V cavity preparations, how did the results compare to the other evaluation methods?

    <p>The results were quite different from the other methods</p> Signup and view all the answers

    Which of the following evaluation methods was NOT used in this study?

    <p>Clinical trial</p> Signup and view all the answers

    In the implantation test, at what time point could the reactions NOT be determined?

    <p>7 days</p> Signup and view all the answers

    What is a limitation of human clinical trials mentioned in the text?

    <p>No histology is performed</p> Signup and view all the answers

    Why are teeth from young orthodontic patients considered for usage tests?

    <p>They have open apices</p> Signup and view all the answers

    What type of animals are typically chosen for usage tests?

    <p>Dogs, monkeys, and sheep</p> Signup and view all the answers

    What is a major disadvantage of animal tests based on the text?

    <p>Difficult interpretation, high cost, and ethical concerns</p> Signup and view all the answers

    Why are animal models with anatomy similar to humans preferred for usage tests?

    <p>To ensure clinical relevance</p> Signup and view all the answers

    What can be impossible to evaluate from clinical symptoms alone in human clinical trials?

    <p>Pulp damage</p> Signup and view all the answers

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