Rufinamide: Pharmacology Overview
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Questions and Answers

What is the primary mechanism of action of rufinamide?

  • It modulates the activity of sodium channels, leading to a longer inactive state (correct)
  • It modulates the activity of GABA receptors
  • It inhibits sodium channel inactivation
  • It inhibits the reuptake of glutamate

    • Which of the following statements about the pharmacokinetics of rufinamide is correct?

  • Rufinamide is extensively metabolized into active metabolites
  • Rufinamide is completely absorbed after oral administration
  • The half-life of rufinamide is 6 to 10 hours (correct)
  • Food decreases the absorption of rufinamide

    • Which patient population is rufinamide approved for?

  • Adjunctive treatment for seizures associated with Lennox-Gastaut syndrome (LGS) in adults only
  • Monotherapy for focal seizures in pediatric patients
  • Monotherapy for generalized seizures in adults
  • Adjunctive treatment for seizures associated with LGS in adults and pediatric patients aged 1 year or older (correct)

    • Which of the following is a precaution when using rufinamide?

    <p>Monitoring for suicidality</p> Signup and view all the answers

    What is the contraindication for rufinamide?

    <p>Familial short QT syndrome</p> Signup and view all the answers

    How should rufinamide be discontinued to prevent seizure exacerbation?

    <p>Taper the dose by 25% every 2 days</p> Signup and view all the answers

    Which of the following is a common adverse drug reaction (ADR) associated with rufinamide in children?

    <p>All of the above</p> Signup and view all the answers

    What is the risk associated with rufinamide that must be weighed against its benefits?

    <p>Increased risk of suicidal behavior or ideation</p> Signup and view all the answers

    Which of the following is a potential symptom of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated with rufinamide?

    <p>All of the above</p> Signup and view all the answers

    What is the effect of coadministering rufinamide with carbamazepine?

    <p>Carbamazepine levels decrease, and rufinamide levels increase</p> Signup and view all the answers

    Which of the following is NOT a common adverse drug reaction (ADR) associated with rufinamide in adults, according to the text?

    <p>Tachycardia</p> Signup and view all the answers

    What is the effect of coadministering rufinamide with valproate?

    <p>Rufinamide levels increase</p> Signup and view all the answers

    Which of the following statements about the pharmacokinetics of zonisamide is correct?

    <p>Zonisamide has a higher concentration in red blood cells than in plasma</p> Signup and view all the answers

    What is the approved indication for zonisamide, according to the text?

    <p>Partial seizures in adults</p> Signup and view all the answers

    Which of the following statements about the mechanism of action of zonisamide is correct?

    <p>It blocks voltage-dependent sodium and calcium channels</p> Signup and view all the answers

    What is the elimination half-life of zonisamide in red blood cells?

    <p>105 hours</p> Signup and view all the answers

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