16 Questions
What is the primary mechanism of action of rufinamide?
It modulates the activity of sodium channels, leading to a longer inactive state
Which of the following statements about the pharmacokinetics of rufinamide is correct?
The half-life of rufinamide is 6 to 10 hours
Which patient population is rufinamide approved for?
Adjunctive treatment for seizures associated with LGS in adults and pediatric patients aged 1 year or older
Which of the following is a precaution when using rufinamide?
Monitoring for suicidality
What is the contraindication for rufinamide?
Familial short QT syndrome
How should rufinamide be discontinued to prevent seizure exacerbation?
Taper the dose by 25% every 2 days
Which of the following is a common adverse drug reaction (ADR) associated with rufinamide in children?
All of the above
What is the risk associated with rufinamide that must be weighed against its benefits?
Increased risk of suicidal behavior or ideation
Which of the following is a potential symptom of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated with rufinamide?
All of the above
What is the effect of coadministering rufinamide with carbamazepine?
Carbamazepine levels decrease, and rufinamide levels increase
Which of the following is NOT a common adverse drug reaction (ADR) associated with rufinamide in adults, according to the text?
Tachycardia
What is the effect of coadministering rufinamide with valproate?
Rufinamide levels increase
Which of the following statements about the pharmacokinetics of zonisamide is correct?
Zonisamide has a higher concentration in red blood cells than in plasma
What is the approved indication for zonisamide, according to the text?
Partial seizures in adults
Which of the following statements about the mechanism of action of zonisamide is correct?
It blocks voltage-dependent sodium and calcium channels
What is the elimination half-life of zonisamide in red blood cells?
105 hours
This quiz provides an overview of the pharmacology of Rufinamide, including its approved uses, pharmacodynamics, and pharmacokinetics. Learn about its mechanism of action in modulating sodium channels and its absorption after oral administration.
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