Rufinamide: Pharmacology Overview
16 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mechanism of action of rufinamide?

  • It modulates the activity of sodium channels, leading to a longer inactive state (correct)
  • It modulates the activity of GABA receptors
  • It inhibits sodium channel inactivation
  • It inhibits the reuptake of glutamate

Which of the following statements about the pharmacokinetics of rufinamide is correct?

  • Rufinamide is extensively metabolized into active metabolites
  • Rufinamide is completely absorbed after oral administration
  • The half-life of rufinamide is 6 to 10 hours (correct)
  • Food decreases the absorption of rufinamide

Which patient population is rufinamide approved for?

  • Adjunctive treatment for seizures associated with Lennox-Gastaut syndrome (LGS) in adults only
  • Monotherapy for focal seizures in pediatric patients
  • Monotherapy for generalized seizures in adults
  • Adjunctive treatment for seizures associated with LGS in adults and pediatric patients aged 1 year or older (correct)

Which of the following is a precaution when using rufinamide?

<p>Monitoring for suicidality (C)</p> Signup and view all the answers

What is the contraindication for rufinamide?

<p>Familial short QT syndrome (B)</p> Signup and view all the answers

How should rufinamide be discontinued to prevent seizure exacerbation?

<p>Taper the dose by 25% every 2 days (D)</p> Signup and view all the answers

Which of the following is a common adverse drug reaction (ADR) associated with rufinamide in children?

<p>All of the above (D)</p> Signup and view all the answers

What is the risk associated with rufinamide that must be weighed against its benefits?

<p>Increased risk of suicidal behavior or ideation (A)</p> Signup and view all the answers

Which of the following is a potential symptom of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated with rufinamide?

<p>All of the above (D)</p> Signup and view all the answers

What is the effect of coadministering rufinamide with carbamazepine?

<p>Carbamazepine levels decrease, and rufinamide levels increase (B)</p> Signup and view all the answers

Which of the following is NOT a common adverse drug reaction (ADR) associated with rufinamide in adults, according to the text?

<p>Tachycardia (C)</p> Signup and view all the answers

What is the effect of coadministering rufinamide with valproate?

<p>Rufinamide levels increase (A)</p> Signup and view all the answers

Which of the following statements about the pharmacokinetics of zonisamide is correct?

<p>Zonisamide has a higher concentration in red blood cells than in plasma (D)</p> Signup and view all the answers

What is the approved indication for zonisamide, according to the text?

<p>Partial seizures in adults (D)</p> Signup and view all the answers

Which of the following statements about the mechanism of action of zonisamide is correct?

<p>It blocks voltage-dependent sodium and calcium channels (C)</p> Signup and view all the answers

What is the elimination half-life of zonisamide in red blood cells?

<p>105 hours (C)</p> Signup and view all the answers
Use Quizgecko on...
Browser
Open
Browser
Browser