Routes of Drug Administration Lecture Quiz

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Questions and Answers

What is a route of administration?

  • The action of a drug on the body
  • The quantity of drug required for administration
  • The path by which a drug is brought into contact with the body (correct)
  • The process of manufacturing pharmaceutical drugs

What determines the choice of route of administration?

  • The price of the drug
  • Ease of administration, site of action, onset of action (correct)
  • The expiration date of the drug
  • The color and shape of the drug

What is the first-pass effect?

  • The initial reaction of the body to a new drug
  • The quantity of drug needed for treatment
  • Extent to which a drug is metabolized by the liver before reaching systemic circulation (correct)
  • The duration of action of a drug

How does liver metabolism affect drug bioavailability?

<p>The greater the first pass effect, the lower the bioavailability of the drug (A)</p> Signup and view all the answers

What does liver metabolism do to active drugs?

<p>Breaks down active drugs to inactive metabolites for elimination (C)</p> Signup and view all the answers

Which factor does NOT influence the choice of route of administration?

<p>Color of the drug (A)</p> Signup and view all the answers

What is the first-pass effect?

<p>The extent to which a drug is metabolized by the liver before reaching systemic circulation (B)</p> Signup and view all the answers

What role does liver metabolism play in drug bioavailability?

<p>It decreases drug bioavailability by breaking down active drugs into inactive metabolites (B)</p> Signup and view all the answers

How does the first-pass effect affect the bioavailability of a drug?

<p>It decreases bioavailability by metabolizing drugs before systemic circulation (B)</p> Signup and view all the answers

What is the purpose of administering drugs through different routes?

<p>To avoid liver metabolism and enhance bioavailability (D)</p> Signup and view all the answers

Which factor has the greatest influence on the choice of route of drug administration?

<p>Metabolism by the liver (B)</p> Signup and view all the answers

What is the primary purpose of administering drugs through different routes?

<p>To achieve optimal drug bioavailability (A)</p> Signup and view all the answers

How does liver metabolism affect the bioavailability of a drug?

<p>It reduces the bioavailability by breaking down active drugs into inactive metabolites (D)</p> Signup and view all the answers

What is the first-pass effect in drug administration?

<p>The percentage of a drug metabolized by the liver before reaching systemic circulation (C)</p> Signup and view all the answers

What role does first-pass effect play in determining the bioavailability of a drug?

<p>It decreases the bioavailability by metabolizing a portion of the active drug (B)</p> Signup and view all the answers

Flashcards

Route of Administration

The path a drug takes into the body.

First-Pass Effect

Liver metabolizing a drug before it enters the bloodstream.

Drug Bioavailability

The percentage of drug reaching the systemic circulation.

Factors influencing route choice

Ease of administration, site of action, and onset of action.

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Liver Metabolism effect

Breaks down active drugs, impacting bioavailability.

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Drug Bioavailability Impact

First-pass effect significantly reduces bioavailability.

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Route choice influence

Factors like administration ease, target location, and speed determine choice.

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Purpose of multiple routes

Achieving optimal drug bioavailability by avoiding initial liver metabolism.

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Non-influencing factor in route choice

Drug color has no impact on the best route of administration.

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Primary route choice driver

Liver's metabolism of the drug is the primary factor determining the route of administration.

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First-pass effect definition

Extent of liver metabolism before systemic circulation.

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Bioavailability and first-pass effect link

High first-pass effect lowers drug bioavailability.

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Optimal Drug Bioavailability

Administering a drug via different routes to enhance its effectiveness by bypassing liver metabolism.

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First-pass effect role in bioavailability

Liver metabolism reduces drug availability by breaking down active drugs into inactive metabolites before the drug reaches the rest of the body.

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