Role of NADPH in Reductive Biosynthesis and ROS Reversal
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Questions and Answers

What is the role of the pentose phosphate pathway in the glutathione peroxidase reaction of erythrocytes?

  • To produce energy in the form of ATP for the enzyme reaction
  • To generate reducing power (NADPH) for the regeneration of reduced glutathione (correct)
  • To synthesize proteins needed in the enzyme reaction
  • To degrade glucose to produce carbon dioxide
  • What is the primary function of the pentose phosphate pathway in erythrocytes?

  • To provide ribose-5-phosphate for nucleotide synthesis (correct)
  • To generate ATP for cell energy
  • To store excess glucose as glycogen
  • To break down fatty acids for energy production
  • Why is the pentose phosphate pathway considered essential for erythrocytes?

  • Because erythrocytes do not require NADPH for redox reactions
  • Because erythrocytes lack mitochondria for other energy-producing pathways (correct)
  • Because erythrocytes can produce all necessary nucleotides without this pathway
  • Because erythrocytes have abundant glycogen reserves
  • How does the pentose phosphate pathway contribute to protecting erythrocytes from oxidative damage?

    <p>By producing NADPH which regenerates reduced glutathione to combat oxidative stress</p> Signup and view all the answers

    How does the deficiency of glucose-6-phosphate dehydrogenase (G6PD) enzyme affect the pentose phosphate pathway in erythrocytes?

    <p>It impairs NADPH production, leading to increased susceptibility to oxidative damage</p> Signup and view all the answers

    Which statement best describes the relationship between the pentose phosphate pathway and red blood cells (erythrocytes)?

    <p>The pentose phosphate pathway is crucial for red blood cells as it provides NADPH and ribose-5-phosphate.</p> Signup and view all the answers

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