18 Questions
Which cells are responsible for the uptake of antigens in secondary lymphoid tissues?
Dendritic cells (DCs)
Where can immune complexes be found in relation to follicular dendritic cells (FDCs)?
On the surface of FDCs
How do T and B cells enter the spleen in relation to the delivery of antigens?
Via central arteriole
Where do T and B cells migrate to after leaving the marginal sinus in the spleen?
Paracortex
What structures serve as anatomic crossroads for interactions of antigens and lymphocytes?
Lymph nodes
How do lymphocytes mainly enter lymph nodes from the blood?
Via specialized blood vessels named high endothelial venules (HEVs)
What is the primary function of plasmacytoid dendritic cells (pDCs) in the immune system?
Producing type I interferons in response to viral infection
Which type of dendritic cell is known for residing in the epidermis of the skin and has dendritic morphology?
Langerhans cell
What is the main function of conventional dendritic cells (cDCs) in nonlymphoid tissues?
Delivering antigens to T cells in lymphoid tissues
Which type of dendritic cell is responsible for antigen cross-presentation?
Langerhans cell
Where are T-cell responses initiated within the immune system?
In secondary lymphoid organs by activated dendritic cells
What distinguishes plasmacytoid dendritic cells (pDCs) from conventional dendritic cells?
Acting as sentinels in early defense against viral infection
What is the main function of the white pulp in the spleen?
Mediate adaptive immune response
Which area in the spleen is mainly concentrated with follicular dendritic cells (FDCs)?
B cell zone
What is the primary role of follicular dendritic cells (FDCs) in the immune response?
Capture of antigens in immune complexes
Where do both antigens and lymphocytes enter the spleen from?
Blood stream
Which type of cells are follicular dendritic cells (FDCs) NOT derived from?
Bone marrow precursors
What do follicular dendritic cells (FDCs) form on their dendrites to capture antigens?
Beads
Learn about the role of dendritic cells, macrophages, and B cells in the immune response. Explore the function of secondary lymphoid organs such as the spleen, lymph nodes, and mucosal lymphoid tissues in Janeway's immunobiology.
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