Role of Antigen Presenting Cells in Immune Response

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Which cells are responsible for the uptake of antigens in secondary lymphoid tissues?

T cells

Follicular dendritic cells (FDCs)

Dendritic cells (DCs) (correct)

Macrophages

Where can immune complexes be found in relation to follicular dendritic cells (FDCs)?

Internalized within FDCs

On the surface of FDCs (correct)

In the cytoplasm of FDCs

Within the nucleus of FDCs

How do T and B cells enter the spleen in relation to the delivery of antigens?

Via central arteriole (correct)

Through the lymphatic system

By crossing the blood-brain barrier

Through specialized exocytosis

Where do T and B cells migrate to after leaving the marginal sinus in the spleen?

Paracortex Signup and view all the answers

What structures serve as anatomic crossroads for interactions of antigens and lymphocytes?

Lymph nodes Signup and view all the answers

How do lymphocytes mainly enter lymph nodes from the blood?

Via specialized blood vessels named high endothelial venules (HEVs) Signup and view all the answers

What is the primary function of plasmacytoid dendritic cells (pDCs) in the immune system?

Producing type I interferons in response to viral infection Signup and view all the answers

Which type of dendritic cell is known for residing in the epidermis of the skin and has dendritic morphology?

Langerhans cell Signup and view all the answers

What is the main function of conventional dendritic cells (cDCs) in nonlymphoid tissues?

Delivering antigens to T cells in lymphoid tissues Signup and view all the answers

Which type of dendritic cell is responsible for antigen cross-presentation?

Langerhans cell Signup and view all the answers

Where are T-cell responses initiated within the immune system?

In secondary lymphoid organs by activated dendritic cells Signup and view all the answers

What distinguishes plasmacytoid dendritic cells (pDCs) from conventional dendritic cells?

Acting as sentinels in early defense against viral infection Signup and view all the answers

What is the main function of the white pulp in the spleen?

Mediate adaptive immune response Signup and view all the answers

Which area in the spleen is mainly concentrated with follicular dendritic cells (FDCs)?

B cell zone Signup and view all the answers

What is the primary role of follicular dendritic cells (FDCs) in the immune response?

Capture of antigens in immune complexes Signup and view all the answers

Where do both antigens and lymphocytes enter the spleen from?

Blood stream Signup and view all the answers

Which type of cells are follicular dendritic cells (FDCs) NOT derived from?

Bone marrow precursors Signup and view all the answers

What do follicular dendritic cells (FDCs) form on their dendrites to capture antigens?

Beads Signup and view all the answers