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Ribosomes and rRNA Quiz
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Ribosomes and rRNA Quiz

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Questions and Answers

Which organelle is known as the 'little organ' in the cytoplasm?

  • Endoplasmic reticulum
  • Cell membrane (Plasmalemma)
  • Ribosomes (correct)
  • Plasma membrane
  • What is the main constituent of the hydrophilic head of a phospholipid?

  • Fatty acids
  • Phosphate (correct)
  • Cholesterol
  • Glycerol
  • Which type of membrane proteins are involved in the transfer of signals and cell adhesion?

  • Peripheral proteins
  • Glycolipids
  • Transmembrane proteins (correct)
  • Glycoproteins
  • What is the carbohydrate-rich zone on the cell surface composed of?

    <p>Glycoproteins</p> Signup and view all the answers

    What is the process by which extracellular signals are converted into intracellular responses?

    <p>Signal transduction</p> Signup and view all the answers

    Which membrane invaginations are composed of lipid rafts and specific proteins?

    <p>Caveolae</p> Signup and view all the answers

    What are membrane proteins that transport various substrates using ATP energy?

    <p>ABC transporters</p> Signup and view all the answers

    What is a structural protein found in the cytoplasmic skeleton of red blood cells?

    <p>Spectrin</p> Signup and view all the answers

    Which type of proteins are responsible for the unidirectional translocation of chemically diverse substrates across cell membranes?

    <p>Glucose transporters</p> Signup and view all the answers

    What plays a role in signal transduction and various diseases, including HDL metabolism?

    <p>Caveolin-1</p> Signup and view all the answers

    What facilitates the transport of water and other small molecules across cell membranes?

    <p>Aquaporins</p> Signup and view all the answers

    Which organelle can generate up to 100 molecules of ATP per second?

    <p>Mitochondria</p> Signup and view all the answers

    What mediates the import of all nucleus-encoded mitochondrial proteins?

    <p>TOM complex</p> Signup and view all the answers

    Which complex mediates the insertion of inner membrane proteins synthesized in the cytosol or mitochondria?

    <p>OXA complex</p> Signup and view all the answers

    What function do mitochondria play in apoptosis?

    <p>Initiate a caspase cascade leading to apoptosis</p> Signup and view all the answers

    What is responsible for cellular maintenance and motion in the cytoplasm?

    <p>Cytoskeleton</p> Signup and view all the answers

    What type of polymers are actin filaments?

    <p>Protein polymers</p> Signup and view all the answers

    What are the monomeric forms of actin filaments called?

    <p>G-actin</p> Signup and view all the answers

    What is responsible for the assembly and disassembly of actin filaments in response to signals?

    <p>Actin-associated proteins</p> Signup and view all the answers

    Which complex mediates insertion of outer membrane proteins in mitochondria?

    <p>TIM complex</p> Signup and view all the answers

    What drives various energy-requiring processes through hydrolysis?

    <p>ATP hydrolysis</p> Signup and view all the answers

    What are the structures that form many invaginations in the inner membrane of mitochondria?

    <p>Cristae</p> Signup and view all the answers

    What can rapidly assemble and disassemble?

    <p>Actin filaments</p> Signup and view all the answers

    Which organelle functions in protein sorting and modifying lipids?

    <p>Golgi complex</p> Signup and view all the answers

    Where are ribosomes assembled?

    <p>Nucleus</p> Signup and view all the answers

    What type of organelle is involved in breaking down macromolecules and cellular debris?

    <p>Lysosomes</p> Signup and view all the answers

    Which organelle is involved in the degradation of misfolded proteins and plays a role in the ubiquitin-proteasome system?

    <p>Proteasomes</p> Signup and view all the answers

    How are proteins transported between different parts of the Golgi complex?

    <p>Vesicular transport</p> Signup and view all the answers

    What is the size of the 8S rRNA molecule?

    <p>4.2 MDa</p> Signup and view all the answers

    Which type of organelle lacks a genome and is involved in various metabolic processes and signaling pathways?

    <p>Peroxisomes</p> Signup and view all the answers

    What is the primary transcript for producing ribosomal subunits processed into?

    <p>Mature rRNAs</p> Signup and view all the answers

    What do peroxisomes lack?

    <p>A genome</p> Signup and view all the answers

    Which protein promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles?

    <p>Filamin</p> Signup and view all the answers

    What are the types of arrays in which actin filaments are organized in animal cells?

    <p>Dendritic networks, bundles, and weblike networks</p> Signup and view all the answers

    Which protein connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix?

    <p>Dystrophin</p> Signup and view all the answers

    Which motor proteins move along microtubules and actin filaments to transport membrane-bound organelles and non-membranous components?

    <p>Kinesins, dyneins, and myosin Vs</p> Signup and view all the answers

    Which structure is composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth?

    <p>Centrosome</p> Signup and view all the answers

    Which protein extends from the Z disc to the M line in the sarcomere and has some parts closely associated with myosin thick filaments while others are elastic?

    <p>Titin</p> Signup and view all the answers

    What are the components of actin-filament-plasmalemma structures?

    <p>Microvilli, stereocilia, contractile rings, cell-to-cell junctions, cell-ECM junctions</p> Signup and view all the answers

    What are the functions of microtubules in the cell?

    <p>Intracellular vesicular transport, positioning of RER and Golgi complex, structuring of cilia and flagella</p> Signup and view all the answers

    What is the structure that vibrates in response to sound waves and opens stress-activated ion channels in the plasma membrane?

    <p>Stereocilia</p> Signup and view all the answers

    Which component is responsible for the formation of microdomains with confined movement of lipids in the plasma membrane?

    <p>Cholesterol</p> Signup and view all the answers

    What is the primary function of cell coat glycocalyx?

    <p>Cell adhesion</p> Signup and view all the answers

    Which type of membrane proteins are involved in the transfer of signals and cell adhesion in the plasma membrane?

    <p>Transmembrane proteins</p> Signup and view all the answers

    What is the characteristic feature of the liquid-disordered state according to the fluid-mosaic model of the plasma membrane?

    <p>Rapid lateral diffusion of phospholipids</p> Signup and view all the answers

    Where are ribosomes assembled?

    <p>Nucleus</p> Signup and view all the answers

    What is the primary transcript for producing ribosomal subunits processed into?

    <p>Mature rRNAs</p> Signup and view all the answers

    Which organelle functions in protein sorting and modifying lipids?

    <p>Golgi complex</p> Signup and view all the answers

    What facilitates the transport of water and other small molecules across cell membranes?

    <p>Aquaporins</p> Signup and view all the answers

    Which organelle is involved in breaking down macromolecules and cellular debris?

    <p>Lysosomes</p> Signup and view all the answers

    Which type of proteins are responsible for the unidirectional translocation of chemically diverse substrates across cell membranes?

    <p>Permeases</p> Signup and view all the answers

    Which protein connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix?

    <p>Laminin</p> Signup and view all the answers

    Which organelle is most likely to have evolved from bacteria by endocytosis?

    <p>Mitochondria</p> Signup and view all the answers

    What is the primary function of the matrix of mitochondria?

    <p>Generation of ATP</p> Signup and view all the answers

    What drives the generation of ATP through oxidative phosphorylation in mitochondria?

    <p>ATP hydrolysis</p> Signup and view all the answers

    What protein is responsible for mediating the import of all nucleus-encoded mitochondrial proteins?

    <p>TIM complex</p> Signup and view all the answers

    What is the primary role of mitochondria in apoptosis?

    <p>Cytochrome c release</p> Signup and view all the answers

    Which protein promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles?

    <p>Gc protein</p> Signup and view all the answers

    What are the fast-growing and slow-growing ends of actin filaments referred to as?

    <ul> <li>and - ends</li> </ul> Signup and view all the answers

    Which type of proteins are responsible for the unidirectional translocation of chemically diverse substrates across cell membranes?

    <p>Transport proteins</p> Signup and view all the answers

    What is a structural protein found in the cytoplasmic skeleton of red blood cells?

    <p>Spectrin</p> Signup and view all the answers

    What are the types of structures that form many invaginations in the inner membrane of mitochondria?

    <p>Cristae</p> Signup and view all the answers

    What are actin filaments composed of?

    <p>Actin and actin-associated proteins</p> Signup and view all the answers

    Which process involves the transport of large molecules into the cell?

    <p>Endocytosis</p> Signup and view all the answers

    What membrane proteins are responsible for transporting various substrates using ATP energy?

    <p>ABC transporters</p> Signup and view all the answers

    Which protein is a key player in tumorigenesis and is associated with caveolae?

    <p>Caveolin-1</p> Signup and view all the answers

    Which organelle is primarily responsible for the synthesis and insertion of transmembrane proteins?

    <p>Rough endoplasmic reticulum</p> Signup and view all the answers

    What is the process by which extracellular signals are converted into intracellular responses?

    <p>Signal transduction</p> Signup and view all the answers

    Which type of membrane invagination is composed of lipid rafts and specific proteins?

    <p>Caveolae</p> Signup and view all the answers

    What is responsible for the synthesis of lipids and sequestering Ca2+ in the cell?

    <p>Smooth endoplasmic reticulum</p> Signup and view all the answers

    Which group of proteins are responsible for the unidirectional translocation of chemically diverse substrates across cell membranes?

    <p>ABC transporters</p> Signup and view all the answers

    What is a major intracellular membrane system that constantly reorganizes and accounts for 50% of the total cellular membrane?

    <p>Endoplasmic reticulum (ER)</p> Signup and view all the answers

    What membrane proteins facilitate the transport of water and other small molecules across cell membranes?

    <p>Aquaporins</p> Signup and view all the answers

    What is a structural protein found in the cytoplasmic skeleton of red blood cells, forming a large, stable structure with two chains?

    <p>Spectrin</p> Signup and view all the answers

    What plays a role in HDL metabolism, signal transduction, and various diseases?

    <p>Caveolin-1</p> Signup and view all the answers

    Which protein helps organize membrane domains by interacting with transmembrane proteins and the underlying cytoskeleton?

    <p>ERM proteins</p> Signup and view all the answers

    What is the giant protein that extends from the Z disc to the M line in the sarcomere?

    <p>Titin</p> Signup and view all the answers

    Which motor proteins move along microtubules and actin filaments, transporting membrane-bound organelles and non-membranous components?

    <p>Kinesins</p> Signup and view all the answers

    What is the major microtubule-organizing center composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth?

    <p>Centrosome</p> Signup and view all the answers

    Which protein connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix?

    <p>Dystrophin</p> Signup and view all the answers

    What are the functions of microtubules in the cell?

    <p>Microtubules have various functions in the cell, including intracellular vesicular transport, positioning of RER and Golgi complex, structuring of MTOC/centrosome, structuring of cilia and flagella, and mitotic spindle formation.</p> Signup and view all the answers

    What protein promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles?

    <p>Filamin</p> Signup and view all the answers

    What human diseases are associated with motor proteins and microtubules?

    <p>Charcot-Marie-Tooth type 2A disease, hereditary spastic paraplegia, Griscelli's syndrome, and Kartagener's syndrome</p> Signup and view all the answers

    What are actin-filament-plasmalemma structures?

    <p>Structures under the microscope as a brush border or vibrate in response to sound waves.</p> Signup and view all the answers

    What is the structure that vibrates in response to sound waves and opens stress-activated ion channels in the plasma membrane?

    <p>Stereocilia</p> Signup and view all the answers

    Which organelle is responsible for protein sorting and modifying lipids?

    <p>Golgi Apparatus</p> Signup and view all the answers

    What is the carbohydrate-rich zone on the cell surface composed of?

    <p>Proteoglycans</p> Signup and view all the answers

    What is the primary function of cell coat glycocalyx?

    <p>Protection from pathogens</p> Signup and view all the answers

    Which type of proteins are involved in the transfer of signals and cell adhesion in the plasma membrane?

    <p>Receptor Proteins</p> Signup and view all the answers

    Which process involves the transport of large molecules in and out of cells?

    <p>Endocytosis</p> Signup and view all the answers

    Which membrane proteins transport various substrates using ATP energy?

    <p>ABC transporters</p> Signup and view all the answers

    What is the characteristic size of caveolae?

    <p>50-100 nm</p> Signup and view all the answers

    Which protein is associated with caveolae and is a target of oncogenes and tumor suppressor proteins?

    <p>Caveolin-1</p> Signup and view all the answers

    What is the primary role of mitochondria in apoptosis?

    <p>Release of cytochrome c into the cytosol</p> Signup and view all the answers

    What is the primary role of the rough endoplasmic reticulum (RER)?

    <p>Protein synthesis and insertion of transmembrane proteins</p> Signup and view all the answers

    What are the types of structures that form many invaginations in the inner membrane of mitochondria?

    <p>Cristae</p> Signup and view all the answers

    Which organelle is involved in the synthesis of lipids and sequesters Ca2+?

    <p>Endoplasmic reticulum (ER)</p> Signup and view all the answers

    What facilitates the transport of water and other small molecules across cell membranes?

    <p>Porins</p> Signup and view all the answers

    What is the main function of the signal recognition particle (SRP) during translation?

    <p>Identifying target membranes for proteins</p> Signup and view all the answers

    What is responsible for cellular maintenance and motion in the cytoplasm?

    <p>Cytoskeleton</p> Signup and view all the answers

    Which protein contributes to 90% of cancer deaths in the USA by exporting anticancer drugs?

    <p>P-glycoprotein</p> Signup and view all the answers

    What are actin filaments composed of?

    <p>Actin and actin-associated proteins</p> Signup and view all the answers

    What plays a role in HDL metabolism, signal transduction, and various diseases?

    <p>Lipid homeostasis</p> Signup and view all the answers

    What drives various energy-requiring processes through hydrolysis?

    <p>ATP hydrolysis</p> Signup and view all the answers

    What facilitates the transport of water and other small molecules across cell membranes?

    <p>Aquaporins</p> Signup and view all the answers

    Which protein mediates the import of all nucleus-encoded mitochondrial proteins?

    <p>TIM complex</p> Signup and view all the answers

    What contributes to increased vascular relaxation due to increased nitric oxide?

    <p>Caveolin-1 loss</p> Signup and view all the answers

    What can rapidly assemble and disassemble?

    <ul> <li>end of actin filaments</li> </ul> Signup and view all the answers

    What is responsible for the assembly and disassembly of actin filaments in response to signals?

    <p>Motor proteins</p> Signup and view all the answers

    What is a type of filamentous (F-actin) actin?

    <ul> <li>end of actin filaments</li> </ul> Signup and view all the answers

    What is a function of the matrix of mitochondria?

    <p>Citric acid cycle</p> Signup and view all the answers

    Which protein functions as a cytoskeletal component in the cellular maintenance and motion?

    <p>Actin</p> Signup and view all the answers

    Which organelle is involved in the degradation of misfolded proteins and plays a role in the ubiquitin-proteasome system?

    <p>Proteasomes</p> Signup and view all the answers

    Where are ribosomes assembled?

    <p>Nucleus</p> Signup and view all the answers

    What type of polymers are actin filaments?

    <p>Proteins</p> Signup and view all the answers

    Which type of membrane proteins are involved in the transfer of signals and cell adhesion in the plasma membrane?

    <p>Transmembrane proteins</p> Signup and view all the answers

    What drives the generation of ATP through oxidative phosphorylation in mitochondria?

    <p>Mitochondria</p> Signup and view all the answers

    What is the primary function of cell coat glycocalyx?

    <p>Cell-to-cell recognition</p> Signup and view all the answers

    What are the monomeric forms of actin filaments called?

    <p>G-actin</p> Signup and view all the answers

    Which protein promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles?

    <p>Myosin II</p> Signup and view all the answers

    Which protein connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix?

    <p>Integrin</p> Signup and view all the answers

    What are the major microtubule-organizing centers composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth?

    <p>Centrosomes</p> Signup and view all the answers

    What type of proteins are responsible for the unidirectional translocation of chemically diverse substrates across cell membranes?

    <p>Transporter proteins</p> Signup and view all the answers

    What can rapidly assemble and disassemble?

    <p>Actin filaments</p> Signup and view all the answers

    Which protein is responsible for cross-linking actin filaments into a parallel array?

    <p>Filamin</p> Signup and view all the answers

    What is the primary function of ERM proteins (ezrin, radixin, and moesin) in animal cells?

    <p>Organizing membrane domains</p> Signup and view all the answers

    What is the major function of microtubules in the cell?

    <p>Mitotic spindle formation</p> Signup and view all the answers

    What is the composition of the centrosome, a major microtubule-organizing center?

    <p>Two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC)</p> Signup and view all the answers

    What is the primary function of dystrophin in animal cells?

    <p>Connecting the extra- and intracellular protective layers</p> Signup and view all the answers

    What are the specific structures that act as actin-filament-plasmalemma structures in animal cells?

    <p>All of the above</p> Signup and view all the answers

    Which motor protein is responsible for transporting membrane-bound organelles and non-membranous components along microtubules?

    <p>Kinesins</p> Signup and view all the answers

    What is the primary role of titin in the sarcomere?

    <p>Extending from the Z disc to the M line</p> Signup and view all the answers

    Which human disease is associated with motor proteins and microtubules?

    <p>Charcot-Marie-Tooth type 2A disease</p> Signup and view all the answers

    What is the role of myosins in animal cells?

    <p>Assembly and disassembly of actin filaments</p> Signup and view all the answers

    Study Notes

    • Actin filaments are organized into various types of arrays in animal cells, including dendritic networks, bundles, and weblike networks.

    • Actin filament structures are maintained and assembled by bundling proteins and gel-forming proteins.

    • Bundling proteins cross-link actin filaments into a parallel array, while gel-forming proteins hold two actin filaments together at a large angle to each other.

    • Filamin promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles.

    • ERM proteins (ezrin, radixin, and moesin) help organize membrane domains by interacting with transmembrane proteins and the underlying cytoskeleton.

    • Actin-filament-plasmalemma structures include microvilli, lamellipodia, filopodia, stereocilia, contractile rings, cell-to-cell junctions, and cell-ECM junctions.

    • Microvilli are under the microscope as a brush border, while stereocilia in hair cells vibrate in response to sound waves and open stress-activated ion channels in the plasma membrane.

    • The human genome includes 40 myosin genes, with myosins having one-headed or two-headed motor domains.

    • Titin is a giant protein that extends from the Z disc to the M line in the sarcomere, with some parts closely associated with myosin thick filaments and others being elastic.

    • Dystrophin connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix.

    • Dystrophin-associated proteins, such as sarcoglycan complex and laminin, are involved in various types of muscular dystrophies.

    • Microtubules are polymers of the protein tubulin, which have a more complex structure and diverse roles in the cell.

    • Microtubules are long, straight and rigid tubular-appearing structures that are typically attached to a single microtubule-organizing center (MTOC) called a centrosome.

    • Microtubules are continuously assembled and disassembled, and are regulated by microtubule-associated proteins.

    • Spatial and temporal organization of molecules and organelles is ensured by their intracellular transport to various destinations within the cytoplasm.

    • Motor proteins, including kinesins, dyneins, and myosin Vs, move along microtubules and actin filaments, transporting membrane-bound organelles and non-membranous components.

    • Human diseases, such as Charcot-Marie-Tooth type 2A disease, hereditary spastic paraplegia, Griscelli's syndrome, and Kartagener's syndrom, are associated with motor proteins and microtubules.

    • Microtubules have various functions in the cell, including intracellular vesicular transport, positioning of RER and Golgi complex, structuring of MTOC/centrosome, structuring of cilia and flagella, and mitotic spindle formation.

    • The centrosome, a major microtubule-organizing center, is composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth.

    • Microtubules are nucleated at their negative end with the positive end growing outward from each MTOC.

    • Actin filaments are organized into various types of arrays in animal cells, including dendritic networks, bundles, and weblike networks.

    • Actin filament structures are maintained and assembled by bundling proteins and gel-forming proteins.

    • Bundling proteins cross-link actin filaments into a parallel array, while gel-forming proteins hold two actin filaments together at a large angle to each other.

    • Filamin promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles.

    • ERM proteins (ezrin, radixin, and moesin) help organize membrane domains by interacting with transmembrane proteins and the underlying cytoskeleton.

    • Actin-filament-plasmalemma structures include microvilli, lamellipodia, filopodia, stereocilia, contractile rings, cell-to-cell junctions, and cell-ECM junctions.

    • Microvilli are under the microscope as a brush border, while stereocilia in hair cells vibrate in response to sound waves and open stress-activated ion channels in the plasma membrane.

    • The human genome includes 40 myosin genes, with myosins having one-headed or two-headed motor domains.

    • Titin is a giant protein that extends from the Z disc to the M line in the sarcomere, with some parts closely associated with myosin thick filaments and others being elastic.

    • Dystrophin connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix.

    • Dystrophin-associated proteins, such as sarcoglycan complex and laminin, are involved in various types of muscular dystrophies.

    • Microtubules are polymers of the protein tubulin, which have a more complex structure and diverse roles in the cell.

    • Microtubules are long, straight and rigid tubular-appearing structures that are typically attached to a single microtubule-organizing center (MTOC) called a centrosome.

    • Microtubules are continuously assembled and disassembled, and are regulated by microtubule-associated proteins.

    • Spatial and temporal organization of molecules and organelles is ensured by their intracellular transport to various destinations within the cytoplasm.

    • Motor proteins, including kinesins, dyneins, and myosin Vs, move along microtubules and actin filaments, transporting membrane-bound organelles and non-membranous components.

    • Human diseases, such as Charcot-Marie-Tooth type 2A disease, hereditary spastic paraplegia, Griscelli's syndrome, and Kartagener's syndrom, are associated with motor proteins and microtubules.

    • Microtubules have various functions in the cell, including intracellular vesicular transport, positioning of RER and Golgi complex, structuring of MTOC/centrosome, structuring of cilia and flagella, and mitotic spindle formation.

    • The centrosome, a major microtubule-organizing center, is composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth.

    • Microtubules are nucleated at their negative end with the positive end growing outward from each MTOC.

    • Actin filaments are organized into various types of arrays in animal cells, including dendritic networks, bundles, and weblike networks.

    • Actin filament structures are maintained and assembled by bundling proteins and gel-forming proteins.

    • Bundling proteins cross-link actin filaments into a parallel array, while gel-forming proteins hold two actin filaments together at a large angle to each other.

    • Filamin promotes the formation of a loose and highly viscous gel by clamping together two actin filaments roughly at right angles.

    • ERM proteins (ezrin, radixin, and moesin) help organize membrane domains by interacting with transmembrane proteins and the underlying cytoskeleton.

    • Actin-filament-plasmalemma structures include microvilli, lamellipodia, filopodia, stereocilia, contractile rings, cell-to-cell junctions, and cell-ECM junctions.

    • Microvilli are under the microscope as a brush border, while stereocilia in hair cells vibrate in response to sound waves and open stress-activated ion channels in the plasma membrane.

    • The human genome includes 40 myosin genes, with myosins having one-headed or two-headed motor domains.

    • Titin is a giant protein that extends from the Z disc to the M line in the sarcomere, with some parts closely associated with myosin thick filaments and others being elastic.

    • Dystrophin connects the extra- and intracellular protective layers and links the cytoskeleton to the extracellular matrix.

    • Dystrophin-associated proteins, such as sarcoglycan complex and laminin, are involved in various types of muscular dystrophies.

    • Microtubules are polymers of the protein tubulin, which have a more complex structure and diverse roles in the cell.

    • Microtubules are long, straight and rigid tubular-appearing structures that are typically attached to a single microtubule-organizing center (MTOC) called a centrosome.

    • Microtubules are continuously assembled and disassembled, and are regulated by microtubule-associated proteins.

    • Spatial and temporal organization of molecules and organelles is ensured by their intracellular transport to various destinations within the cytoplasm.

    • Motor proteins, including kinesins, dyneins, and myosin Vs, move along microtubules and actin filaments, transporting membrane-bound organelles and non-membranous components.

    • Human diseases, such as Charcot-Marie-Tooth type 2A disease, hereditary spastic paraplegia, Griscelli's syndrome, and Kartagener's syndrom, are associated with motor proteins and microtubules.

    • Microtubules have various functions in the cell, including intracellular vesicular transport, positioning of RER and Golgi complex, structuring of MTOC/centrosome, structuring of cilia and flagella, and mitotic spindle formation.

    • The centrosome, a major microtubule-organizing center, is composed of two centrioles surrounded by an amorphous matrix containing γ-tubulin ring complexes (γ-TuRC) that serve as templates for microtubule growth.

    • Microtubules are nucleated at their negative end with the positive end growing outward from each MTOC.

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