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Ribonucleotide Reductase and Nucleotide Synthesis Quiz

12 Questions

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Ribonucleotide Reductase and Nucleotide Synthesis Quiz

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Questions and Answers

What is the metabolic consequence of ADA deficiency?

Increased conversion of xanthine and guanine to urate

Inhibition of maturation of T-cells & B-cells (correct)

Increased purine biosynthesis

Elevated urate levels

Which enzyme converts Adenosine to Inosine?

Adenosine Deaminase (correct)

Ribonucleotide Reductase

Thymidylate Synthase

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

What is the consequence of HGPRT deficiency?

X-linked recessive inheritance

Gout

Self-mutilation behavior

Mental retardation (correct)

Which nucleotide is a powerful antioxidant but can also cause oxidative modifications of proteins and lipids?

Uric Acid Signup and view all the answers

"Regulation of Ribonucleotide Reductase" includes inhibition by which molecule?

dATP Signup and view all the answers

What is the consequence of Uric Acid levels going up due to AMP/GMP catabolism?

Formation of kidney stones and kidney failure Signup and view all the answers

Which enzyme catalyzes the conversion of UMP to CTP in pyrimidine nucleotide biosynthesis?

Cytidylate synthetase Signup and view all the answers

In the reduction of ribonucleotides to deoxyribonucleotides, which enzyme acts on the ribonucleotides?

Ribonucleotide Reductase Signup and view all the answers

Which syndrome is associated with a metabolic basis related to purine and pyrimidine catabolism?

Lesch-Nyhan syndrome Signup and view all the answers

What are the building blocks of DNA known as?

Deoxyribonucleotides Signup and view all the answers

Which enzyme is responsible for converting aspartate to carbamoylaspartate in pyrimidine nucleotide biosynthesis?

Carbamoyl Phosphate Synthetase II Signup and view all the answers

Which enzyme catalyzes the conversion of UTP to CTP in pyrimidine nucleotide biosynthesis?