Rheumatology Acronyms
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Questions and Answers

¿Cuál es el nombre del medicamento que modifica la enfermedad y se utiliza para tratar trastornos reumáticos?

  • DMARD (correct)
  • NSAID
  • COX
  • TNF

¿Qué tipo de células se activan en respuesta a organismos extraños o sustancias antigénicas?

  • Células inmunológicamente competentes (correct)
  • Eosinófilos
  • Macrófagos
  • Células dendríticas

¿Cuál es el nombre del trastorno que causa inflamación crónica en las articulaciones?

  • Artritis psoriásica
  • Osteoartritis
  • Espondilitis anquilosante
  • Artritis reumatoide (correct)

¿Qué tipo de moléculas se liberan durante la respuesta inflamatoria aguda o crónica?

<p>Todas las anteriores (C)</p> Signup and view all the answers

¿Cuál es el nombre del factor que se libera durante la respuesta inmune?

<p>TNF (A)</p> Signup and view all the answers

¿Cuál es el nombre del trastorno que causa inflamación en las articulaciones y piel?

<p>Artritis psoriásica (C)</p> Signup and view all the answers

¿Cuál es el efecto de los alimentos en la biodisponibilidad de la mayoría de los NSAID?

<p>No cambia la biodisponibilidad (D)</p> Signup and view all the answers

¿Cuál es el mecanismo de metabolismo de la mayoría de los NSAID?

<p>Fase I seguida de mecanismos de fase II (B)</p> Signup and view all the answers

¿Qué es la nabumetona?

<p>Un profármaco que se metaboliza en 6MNA (A)</p> Signup and view all the answers

¿Cuál es el efecto de la sulindaco en el cuerpo?

<p>Se metaboliza en un metabolito sulfuro activo (C)</p> Signup and view all the answers

¿Cuál es la función de la enzima CYP2C19 en el metabolismo de los NSAID?

<p>Es un sustrato de la enzima CYP2C19 (A)</p> Signup and view all the answers

¿Qué es el papel de la glucuronidación en el metabolismo de los NSAID?

<p>Es un mecanismo de fase II (A)</p> Signup and view all the answers

¿Cuál es el mecanismo de acción de la azatioprina?

<p>Suprime la síntesis de ácido inosínico y afecta la función de las células B y T (D)</p> Signup and view all the answers

¿Cuál es la dosificación recomendada del apremilast?

<p>30 mg dos veces al día (D)</p> Signup and view all the answers

¿Cuál es el efecto adverso gastrointestinal más común del apremilast?

<p>Diarrhea (D)</p> Signup and view all the answers

¿Cuál es la dosis recomendada del apremilast?

<p>30 mg dos veces al día (D)</p> Signup and view all the answers

¿Cuál es la vía de administración de la azatioprina?

<p>Ambas, oral y subcutánea (B)</p> Signup and view all the answers

¿Cuál es el mecanismo de acción de la azatioprina?

<p>Suprimir la síntesis de ácido inosínico (D)</p> Signup and view all the answers

¿Qué es lo que ocurre con la depuración de creatinina en pacientes que toman apremilast?

<p>Es &lt; 30 mL/minuto (A)</p> Signup and view all the answers

¿Cuál es la enfermedad para la que se indica el apremilast?

<p>Psoriasis en placas (D)</p> Signup and view all the answers

¿Cuál es la indicación principal de la azatioprina?

<p>Artritis reumatoide (C)</p> Signup and view all the answers

¿Cuál es el metabolito activo de la azatioprina?

<p>6-TG (D)</p> Signup and view all the answers

¿Cuáles son los efectos adversos más comunes del apremilast?

<p>Todos los anteriores (B)</p> Signup and view all the answers

¿Cómo se administra la azatioprina?

<p>Por vía oral o subcutánea (A)</p> Signup and view all the answers

¿Cuál es el mecanismo de acción del sarilumab?

<p>Se une a receptores de IL-6 tanto solubles como unidos a membrana (B)</p> Signup and view all the answers

¿Cuál es la dosis habitual de sarilumab?

<p>200 mg cada dos semanas (B)</p> Signup and view all the answers

¿Cuál es el efecto adverso más común del sarilumab?

<p>Infección (B)</p> Signup and view all the answers

¿Qué debe hacerse regularmente durante el tratamiento con sarilumab?

<p>Todas las opciones anteriores (C)</p> Signup and view all the answers

¿Qué enfermedad no debe recibir tratamiento con sarilumab?

<p>Diverticulitis (A)</p> Signup and view all the answers

¿Cuál es la vida media del sarilumab?

<p>8-10 días (C)</p> Signup and view all the answers

Flashcards

What are NSAIDs?

A medication that reduces inflammation by blocking the cyclooxygenase enzymes, which are responsible for the production of prostaglandins, which are involved in inflammation

What are DMARDs?

A group of medications that modify the course of rheumatic diseases, such as rheumatoid arthritis, by suppressing the immune system and slowing down the progression of joint damage.

What is rheumatoid arthritis (RA)?

An auto-immune disease that causes inflammation of the joints, leading to pain, stiffness, swelling, and decreased range of motion. It can affect any joint in the body, most commonly the small joints of the hands and feet.

What is ankylosing spondylitis (AS)?

A chronic inflammatory disease that mainly affects the spine, causing pain, stiffness, and reduced mobility. It can also affect other joints, as well as the eyes, intestines, heart, and lungs.

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What is psoriatic arthritis (PsA)?

A type of arthritis that develops in people with psoriasis, a chronic skin condition characterized by scaly patches of skin. It can affect the joints, tendons, and ligaments, causing pain, stiffness, and swelling.

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What is Juvenile idiopathic arthritis (JIA)?

A type of arthritis that affects children, characterized by inflammation of the joints, causing pain, stiffness, swelling, and limited range of motion.

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What is osteoarthritis (OA)?

A condition characterized by progressive deterioration of cartilage in the joints, leading to pain, stiffness, and swelling. It is most common in the hips, knees, and hands.

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What is Polyarticular JIA (PJIA)?

A type of JIA that affects multiple joints in the body, usually starting in the knees, ankles, and wrists. It is characterized by inflammation of the joints, causing pain, stiffness, and swelling.

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What is oligoarticular JIA?

A type of JIA that affects less than five joints and is characterized by a chronic waxing and waning pattern of inflammation.

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What is Systemic JIA (SJIA)?

A type of JIA that affects the body's systems, like the fever, rash, and lymph node swelling. It is characterized by systemic onset inflammatory symptoms.

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What is Systemic Lupus Erythematosus (SLE)?

An autoimmune disease that affects the immune system, causing inflammation and damage to various organs, such as the joints, skin, kidneys, and heart. It is characterized by pain, stiffness, fatigue, and rash.

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What is Systemic Sclerosis (SSC)?

A connective tissue disorder that causes thickening and hardening of the skin, as well as problems with the blood vessels, joints, and internal organs. It can cause a variety of symptoms, including Raynaud's phenomenon, joint pain, and digestive problems.

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What is Granulomatosis with Polyangiitis (GPA)?

A chronic inflammatory disease that can affect any organ in the body, but most commonly affects the lungs, kidneys, and nervous system. It is characterized by granulomas, which are clusters of immune cells.

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What is cyclooxygenase (COX)?

An enzyme that is responsible for the production of prostaglandins, which are involved in inflammation and pain.

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What are Interleukins (ILs)?

A type of cytokine that is involved in inflammation, immune response, and cell growth. There are a variety of ILs, each with specific functions.

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What is Tumor Necrosis Factor (TNF)?

An important signaling molecule in the immune system, that helps regulate inflammation.

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What are TNF-alpha inhibitors?

A medication that is used to treat autoimmune diseases, such as rheumatoid arthritis, by blocking the action of TNF. This medication is typically given by injection or infusion.

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What are the effects of azathioprine?

A class of medications that suppress the immune system by inhibiting the enzyme inosine monophosphate dehydrogenase, which is involved in the production of nucleic acids, necessary for the growth and function of cells. This leads to a reduction in the production of lymphocytes, which are important for the immune response.

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What is apremilast?

A medication that works by stimulating the production of cyclic AMP, a molecule that helps regulate cellular function, in immune cells. This results in a decrease in inflammation and pain.

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What is sarilumab?

A medication that targets the interleukin-6 (IL-6) receptor, which is involved in inflammation, fever, and other immune responses. By blocking the receptor, it prevents IL-6 from signaling to immune cells, thereby reducing inflammation.

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What is chronic inflammation?

A chronic inflammatory response involving a complex interplay of cells and signaling molecules, like eicosanoids, lipoxygenases, leukotrienes, cytokines, and chemokines.

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What are immunosuppressants?

A type of medication that suppresses the immune system, often used to treat autoimmune diseases, by targeting cells responsible for immune responses.

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What are IL-1 inhibitors?

A medication that blocks the action of IL-1, a signaling molecule that plays a key role in inflammation, which results in a reduction in inflammation and joint damage.

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What is arthritis?

A condition characterized by inflammation of the joints, causing pain, stiffness, swelling, and decreased range of motion.

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What are Biologic Disease Modifying Anti-Rheumatic Drugs (bDMARDs)?

A type of medication that is used to treat autoimmune diseases, such as rheumatoid arthritis, by suppressing the immune system.

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What are Conventional Disease Modifying Anti-Rheumatic Drugs (csDMARDs)?

A type of medication that is used to treat autoimmune diseases, such as rheumatoid arthritis, by suppressing the immune system. These medications are made in a lab, but mimic the effects of natural compounds.

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What is an immune response?

It is a complex process that occurs when the body's immune system is activated by foreign substances or antigens.

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Study Notes

Acronyms and Definitions

  • ACRÓNIMOS: AS (Espondilitis anquilosante), COX (Ciclooxigenasa), DMARD (Medicamento antirreumático modificador de la enfermedad), GPA (Poliangitis granulomatosa), IL (Interleucina), JIA (Artritis idiopática juvenil), NSAID (Antiinflamatorio no esteroideo), OA (Osteoartritis), PsA (Artritis psoriásica), PJIA (Artritis idiopática juvenil poliarticular), RA (Artritis reumatoide), SJIA (Artritis idiopática juvenil sistémica), SLE (Lupus eritematoso sistémico), SSC (Esclerosis sistémica), TNF (Factor de necrosis tumoral)

Immune Response

  • La respuesta inmune se produce cuando las células inmunológicamente competentes se activan en respuesta a organismos extraños o sustancias antigénicas liberadas durante la respuesta inflamatoria aguda o crónica.
  • La inflamación crónica implica la liberación de eicosanoides, lipooxigenasas, leucotrienos, múltiples citocinas y quimiocinas, más una interacción muy compleja de células inmunoactivas.

Fármacos antiinflamatorios no esteroideos

  • La mayoría de los NSAID son altamente metabolizados, algunos por fase I seguidos por mecanismos de fase II y otros solo por glucuronidación directa (fase II).
  • El metabolismo de los NSAID puede ser inducido o inhibido por diferentes medicamentos.
  • La mayoría de estos medicamentos son bien absorbidos y los alimentos no cambian su biodisponibilidad.
  • Se excreta por la orina, y se recomienda reducción de la dosis si la depuración de creatinina es < 30 mL/minuto.

Apremilast

  • El apremilast es un medicamento oral que se administra con un programa de titulación de cinco días hasta la dosis recomendada de 30 mg dos veces al día.
  • Está indicado para psoriasis en placas, artritis psoriásica activa, y posiblemente para úlceras orales en la enfermedad de Behçet.
  • Los principales efectos adversos del apremilast son gastrointestinales, con diarrea y náuseas, aunque también ocurren infecciones de las vías respiratorias.

Azatioprina

  • La azatioprina es un csDMARD que se metaboliza a 6­MP y después hacia su principal metabolito activo, 6­tioguanina (6­TG).
  • La 6­TG suprime la síntesis de ácido inosínico, y finalmente suprime la función de las células B y T, la producción de inmunoglobulina y la secreción de IL­2.
  • La azatioprina puede administrarse por vía oral o subcutánea.
  • Está aprobada en la artritis reumatoide; se usan 2 mg/kg/día por vía oral.

Sarilumab

  • La IL­6 es una citocina proinflamatoria activa en la patogenia de RA.
  • El sarilumab es un bDMARD antagonista del receptor de IL­6, que se une a receptores de IL­6 tanto solubles como unidos a membrana, lo que inhibe así la señalización mediada por IL­6.
  • La dosis habitual es de 200 mg por vía subcutánea cada dos semanas.
  • El fármaco es eficaz en RA, como monoterapia o combinado con metotrexato u otros csDMARD.
  • Los efectos adversos más comunes del sarilumab son la infección, neutropenia, trombocitopenia y anemia, y se requiere vigilancia regular.

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Test your knowledge of medical acronyms related to rheumatology, including arthritis, inflammatory diseases, and medications. Learn to identify and understand the meanings of these important abbreviations in the field of rheumatology. Improve your understanding of rheumatological conditions and their treatments.

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