Rheumatoid Arthritis: Symptoms and Outcomes
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Questions and Answers

What is the primary effect of rheumatoid arthritis on the body?

  • Nerve damage in the affected joints
  • Inflammation of the lining of the synovial joints (correct)
  • Inflammation of the muscles
  • Degeneration of the bones

    • What is the primary goal of treatment in rheumatoid arthritis?

  • To cure the disease
  • To reverse joint deformity
  • To reduce joint pain and inflammation
  • To achieve a low disease activity state (correct)

    • What is the role of disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis?

  • To cure the disease
  • To relieve stiffness and pain
  • To efficiently attenuate disease activity and substantially decrease and/or delay joint deformity (correct)
  • To slow down disease progression

    • What is the significance of early diagnosis in rheumatoid arthritis?

    <p>To achieve desirable outcomes, including reduced joint destruction and disease modifying anti-rheumatic drugs (DMARD)-free remission</p> Signup and view all the answers

    What is the challenge in diagnosing rheumatoid arthritis?

    <p>Reliance on clinical information from the patient's history, physical examination, blood tests, and imaging analysis</p> Signup and view all the answers

    What is the purpose of continuously monitoring disease activity in rheumatoid arthritis?

    <p>To achieve full suppression of disease activity (clinical remission)</p> Signup and view all the answers

    What is the characteristic of rheumatoid arthritis primarily responsible for affecting the body?

    <p>Autoimmune disease</p> Signup and view all the answers

    In rheumatoid arthritis, which group is more frequently affected?

    <p>Females</p> Signup and view all the answers

    What is the primary site of involvement in rheumatoid arthritis?

    <p>Synovial joints</p> Signup and view all the answers

    What is one of the clinical manifestations of symmetrical joint involvement in rheumatoid arthritis?

    <p>Swelling</p> Signup and view all the answers

    What is the desirable outcome of early diagnosis in rheumatoid arthritis?

    <p>Reduced joint destruction</p> Signup and view all the answers

    What is the purpose of disease activity monitoring in rheumatoid arthritis?

    <p>To accurately adjust the treatment regimen</p> Signup and view all the answers

    What is the limitation of anti-inflammatory drugs and corticosteroids in rheumatoid arthritis?

    <p>They don't moderate disease progression</p> Signup and view all the answers

    What is the role of disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis?

    <p>To efficiently attenuate disease activity</p> Signup and view all the answers

    What is the categorization of therapy in rheumatoid arthritis?

    <p>Traditional synthetic, biological, and small molecules</p> Signup and view all the answers

    What is the desired state of disease activity in rheumatoid arthritis management?

    <p>Low disease activity state</p> Signup and view all the answers

    Study Notes

    Rheumatoid Arthritis (RA)

    • RA is a chronic autoimmune disease
    • More frequent in females and commonly observed in the elderly
    • Primarily affects the lining of the synovial joints and can cause progressive disability

    Clinical Manifestations

    • Symmetrical joint involvement
    • Swelling, redness, and limited range of motion

    Desirable Outcomes

    • Reduced joint destruction
    • Less radiologic progression
    • No functional disability
    • Disease modifying anti-rheumatic drugs (DMARD)-free remission

    Diagnosis and Treatment

    • Early diagnosis is challenging and relies on clinical information, physical examination, blood tests, and imaging analysis
    • Treatment strategy aims to expedite diagnosis and rapidly achieve a low disease activity state
    • Continuous monitoring of disease activity is necessary to achieve full suppression (clinical remission)

    Medications

    • Anti-inflammatory drugs (NSAIDs) and corticosteroids relieve stiffness and pain, but do not moderate disease progression
    • DMARDs efficiently attenuate disease activity and decrease/delay joint deformity
    • Therapy classification includes traditional synthetic drugs, biological DMARDs, and potential small molecules

    Pathogenesis

    • Two major subtypes of RA: presence or absence of anti-citrullinated protein antibodies (ACPAs)
    • Citrullination is catalyzed by the calcium-dependent enzyme peptidylarginine-deiminase (PAD)
    • ACPAs can be detected in 67% of RA patients and provide a diagnostic reference for early and undifferentiated arthritis
    • ACPA-positive subset of RA has a more aggressive clinical phenotype

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    Description

    Learn about Rheumatoid Arthritis, a chronic autoimmune disease that affects joints, causing swelling, redness, and limited motion. Understand the importance of early diagnosis for desirable outcomes.

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