Rheumatoid Arthritis Quiz
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Questions and Answers

Which of the following joints are most commonly affected in peripheral arthritis associated with inflammatory bowel disease (IBD)?

  • Interphalangeal joints of the fingers
  • Metatarsophalangeal joints of the feet
  • Small joints of the hands
  • Knees, hips, and shoulders (correct)

    • Which of the following statements about axial arthritis in IBD is NOT true?

  • It is independent of gastrointestinal symptoms
  • It is characterized by sacroiliitis and spondylitis
  • It is exacerbated by prolonged sitting or standing
  • The onset is typically sudden and severe (correct)

    • Which of the following extraintestinal manifestations is NOT commonly associated with inflammatory bowel disease?

  • Uveitis
  • Pyoderma gangrenosum
  • Erythema nodosum
  • Rheumatoid nodules (correct)

    • Which of the following statements about the relationship between peripheral arthritis and bowel activity in IBD is correct?

    <p>Acute peripheral arthritis is strongly correlated with IBD activity</p> Signup and view all the answers

    Which of the following joints is most commonly affected by enthesitis in patients with inflammatory bowel disease?

    <p>Knee</p> Signup and view all the answers

    Which of the following is a characteristic extraarticular manifestation of rheumatoid arthritis?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a characteristic joint deformity associated with rheumatoid arthritis?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a specific serological marker for rheumatoid arthritis?

    <p>Both A and B</p> Signup and view all the answers

    Which of the following is NOT a characteristic morphologic alteration in the joints of patients with rheumatoid arthritis?

    <p>Osteophyte formation</p> Signup and view all the answers

    Which of the following is a potential cardiovascular manifestation of rheumatoid arthritis?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of rheumatoid nodules?

    <p>Tender subcutaneous nodules</p> Signup and view all the answers

    What is the pathway of synovial macrophage to osteoclast in the context of osteoarthritis?

    <p>Synovial macrophage → TGF-β → Osteoblasts → Osteophytes</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Gout?

    <p>More common in females than males</p> Signup and view all the answers

    What condition is characterized by calcification of fibrous and hyaline cartilage resulting in acute pain and swelling in large joints?

    <p>Pseudogout</p> Signup and view all the answers

    Which condition is associated with weakly positively birefringent rhomboid crystals in joint aspirate under polarized light?

    <p>Pseudogout</p> Signup and view all the answers

    What is the primary cause of secondary gout?

    <p>Decreased uric acid excretion</p> Signup and view all the answers

    Which statement best describes the pathogenesis of tophi formation in gout?

    <p>Crystalline deposits in periarticular tissue and synovial membranes from hyperuricemia</p> Signup and view all the answers

    What inflammatory arthritis is mainly transmitted via direct inoculation, spread from adjacent infection, or hematogenous spread?

    <p>Septic Arthritis</p> Signup and view all the answers

    What is a feature that differentiates pseudogout from gout in terms of joint inflammation?

    <p>Cloudy joint aspirate with increased peripheral white cell count and fever</p> Signup and view all the answers

    What is the most common cause of septic arthritis in older adults?

    <p>Staphylococcus aureus</p> Signup and view all the answers

    Anti-RBC antibodies are an example of Type II hypersensitivity reactions.

    <p>True</p> Signup and view all the answers

    In Type III hypersensitivity, immune complexes are deposited in tissues such as the lungs and skin.

    <p>False</p> Signup and view all the answers

    Antinuclear antibodies (ANAs) can target histones and nucleolar antigens in addition to DNA and non-histone proteins bound to RNA.

    <p>True</p> Signup and view all the answers

    The detection of ANAs is typically done through direct immunofluorescence techniques.

    <p>False</p> Signup and view all the answers

    The presence of anti-Smith antibodies is highly specific for systemic lupus erythematosus (SLE).

    <p>True</p> Signup and view all the answers

    Anti-dsDNA antibodies are present in more than 95% of patients with systemic lupus erythematosus (SLE).

    <p>False</p> Signup and view all the answers

    Systemic sclerosis is always associated with a positive antinuclear antibody (ANA) test.

    <p>False</p> Signup and view all the answers

    A speckled ANA pattern is associated with anti-Scl-70 antibodies in systemic sclerosis.

    <p>True</p> Signup and view all the answers

    A centromere ANA pattern is associated with the limited cutaneous subtype of systemic sclerosis.

    <p>True</p> Signup and view all the answers

    A nucleolar ANA pattern is specific for systemic sclerosis and is not seen in other autoimmune conditions.

    <p>False</p> Signup and view all the answers

    Raynaud's phenomenon is always a secondary condition caused by an underlying disease.

    <p>False</p> Signup and view all the answers

    Nailfold capillaroscopy is a useful diagnostic tool to differentiate between primary and secondary Raynaud's phenomenon.

    <p>True</p> Signup and view all the answers

    The homogeneous ANA pattern is associated with antibodies to chromatin or histones.

    <p>True</p> Signup and view all the answers

    The speckled ANA pattern is considered non-specific and can be seen in various autoimmune diseases.

    <p>True</p> Signup and view all the answers

    The nucleolar ANA pattern is associated with antibodies against DNA.

    <p>False</p> Signup and view all the answers

    The presence of any ANA pattern is diagnostic of systemic lupus erythematosus (SLE).

    <p>False</p> Signup and view all the answers

    The rim ANA pattern is caused by antibodies binding to the nuclear membrane.

    <p>True</p> Signup and view all the answers

    The homogeneous and speckled ANA patterns are mutually exclusive and cannot occur simultaneously.

    <p>False</p> Signup and view all the answers

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