Rheology and Viscosity in Pharmaceutical Formulations
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Questions and Answers

What is the physical parameter that can be defined using Poiseuille's law?

  • Viscosity (correct)
  • Density
  • Pressure
  • Temperature
  • What is the purpose of dividing the equation for one liquid by the equation for the second liquid in Poiseuille's law for two fluids?

  • To find the volume of the liquid
  • To determine the ratio of viscosities (correct)
  • To calculate the pressure difference
  • To measure the length of the capillary
  • What is the assumption made when applying Poiseuille's law to two fluids?

  • The viscometer constants are the same (correct)
  • The viscometer constants are different
  • The fluids have different densities
  • The fluids have different viscosities
  • What is the purpose of using a liquid of known density and viscosity, such as water, in Poiseuille's law?

    <p>To calculate the viscosity of the unknown liquid</p> Signup and view all the answers

    What is the unit of measurement for the acceleration due to gravity (g) in Poiseuille's law?

    <p>ms^-2</p> Signup and view all the answers

    What is the term that groups all constant parameters in Poiseuille's law?

    <p>h</p> Signup and view all the answers

    What is the study of the flow and deformation properties of matter?

    <p>Rheology</p> Signup and view all the answers

    What is the resistance of a fluid to flow or movement?

    <p>Viscosity</p> Signup and view all the answers

    Which of the following fluids is easier to stir or pour?

    <p>Water</p> Signup and view all the answers

    What is the main objective of studying rheology in pharmaceutical formulations?

    <p>To understand the flow and deformation properties of matter in pharmaceutical formulations</p> Signup and view all the answers

    What is the unit of shear stress?

    <p>N/m²</p> Signup and view all the answers

    What is the main difference between Newtonian and non-Newtonian fluids?

    <p>Behavior under stress</p> Signup and view all the answers

    What is the relationship between shear rate and shear stress in a Newtonian fluid?

    <p>Shear rate is directly proportional to shear stress</p> Signup and view all the answers

    What is a common application of rheology?

    <p>Pharmaceutical formulations</p> Signup and view all the answers

    What is the dimension of dynamic viscosity?

    <p>N/m²·s</p> Signup and view all the answers

    What is the difference between shear stress and pressure?

    <p>Shear stress is a force per unit of lateral area, while pressure is a force per unit of normal area</p> Signup and view all the answers

    What is the unit of kinematic viscosity?

    <p>m²/s</p> Signup and view all the answers

    What is the characteristic of a fluid with a steeper curve in a viscosity graph?

    <p>More viscous</p> Signup and view all the answers

    What is the unit of viscosity in the given table?

    <p>mPa·s</p> Signup and view all the answers

    What type of fluids obey Newton's law?

    <p>Newtonian fluids</p> Signup and view all the answers

    What is the characteristic of a Non-Newtonian fluid?

    <p>The shear stress is not directly proportional to the shear rate</p> Signup and view all the answers

    What is the name of the flow type characterized by a yield value (σy)?

    <p>Plastic or Bingham flow</p> Signup and view all the answers

    What is the term for the apparent viscosity at a defined shear stress value and temperature?

    <p>Apparent viscosity</p> Signup and view all the answers

    Which of the following is an example of a Pseudoplastic fluid?

    <p>Polyacrylic acid solution</p> Signup and view all the answers

    What is the unit of measurement for dynamic viscosity?

    <p>Pa · s</p> Signup and view all the answers

    How can the dynamic viscosity of a Newtonian fluid be obtained from a plot of shear rate vs shear stress?

    <p>By calculating the slope of the line</p> Signup and view all the answers

    What is the correct statement about the power law?

    <p>n = 1 represents Newtonian flow</p> Signup and view all the answers

    What is the unit of measurement for shear stress?

    <p>Pa</p> Signup and view all the answers

    What is the relationship between shear rate and shear stress in a plot for a Newtonian fluid?

    <p>Shear stress increases linearly with shear rate</p> Signup and view all the answers

    Study Notes

    Rheology and Viscosity

    • Rheology is the study of the flow and deformation properties of matter.
    • Viscosity is the resistance of a fluid to flow or movement.

    Poiseuille's Law

    • For a liquid flowing through a capillary tube, Poiseuille's law states that the viscosity of the fluid is proportional to the pressure difference, radius of the capillary, and length of the capillary, and inversely proportional to the volume of the liquid.
    • The law can be simplified to η = (k * P * L) / (8 * V * t), where η is the viscosity, k is a constant, P is the pressure difference, L is the length of the capillary, V is the volume of the liquid, and t is the time of flow.
    • Poiseuille's law can be used to compare the viscosity of two fluids, where the ratio of the viscosities of the two fluids is equal to the ratio of their flow times.

    Viscosity Measurement

    • The viscosity of a fluid can be measured using a viscometer, which consists of a capillary tube and a pressure difference.
    • The flow time of a fluid through the capillary tube is proportional to its viscosity.

    Types of Fluids

    • Newtonian fluids have a constant viscosity, which means their shear rate is directly proportional to the shear stress.
    • Non-Newtonian fluids have a viscosity that changes with the shear stress, and their behavior can be described by different types of flow, including plastic, pseudoplastic, and dilatant flow.

    Non-Newtonian Fluids

    • Plastic or Bingham flow: the fluid does not flow until a minimum stress (yield value) is applied, and the relationship between shear stress and shear rate is not linear.
    • Pseudoplastic flow: the fluid flows as soon as the shear stress is applied, and the viscosity changes with the shear stress, making it a "shear thinning" fluid.
    • Dilatant flow: the fluid's viscosity increases with the shear stress, making it a "shear thickening" fluid.

    Key Concepts

    • Shear stress (σ) is the tangential force applied per unit of surface area, measured in N/m2.
    • Shear rate (γ) is the rate at which the velocity of flow decreases, measured in s-1.
    • Dynamic viscosity (η) is the coefficient of proportionality between the shear stress and shear rate, measured in Pa·s.
    • Apparent viscosity is the viscosity of a non-Newtonian fluid at a defined shear stress value and temperature.
    • The power law can be used to describe the behavior of non-Newtonian fluids, where the apparent viscosity is proportional to the shear stress raised to a power (n).

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