Podcast
Questions and Answers
What does the Dynamic Viscosity relate to in relation to shear?
What does the Dynamic Viscosity relate to in relation to shear?
- Shear viscosity (correct)
- Creep behavior
- Elastic modulus
- Phase angle
Which of the following test modes is NOT mentioned for rotational rheometers?
Which of the following test modes is NOT mentioned for rotational rheometers?
- Steady shear (correct)
- Oscillation
- Creep
- VisEometry
In complex viscoelastic behavior, the storage modulus indicates which property of a material?
In complex viscoelastic behavior, the storage modulus indicates which property of a material?
- Elastic limit
- Liquid behavior
- Solid nature (correct)
- Viscous nature
What effect does adding water have on an elastic sample according to the content provided?
What effect does adding water have on an elastic sample according to the content provided?
What does the phrase 'Cox Merz rule' refer to in relation to dynamic viscosity?
What does the phrase 'Cox Merz rule' refer to in relation to dynamic viscosity?
What does rheology study?
What does rheology study?
What does viscometry test measure?
What does viscometry test measure?
Why are rheological measurements important?
Why are rheological measurements important?
Which aspect is NOT related to quality control in rheology?
Which aspect is NOT related to quality control in rheology?
What can inadequate mixing during production indicate?
What can inadequate mixing during production indicate?
Which property is a key focus of rheological analysis?
Which property is a key focus of rheological analysis?
What is one reason for process optimization in rheology?
What is one reason for process optimization in rheology?
Which of the following is critical for the assessment of raw materials?
Which of the following is critical for the assessment of raw materials?
What is the formula for shear stress as described in the content?
What is the formula for shear stress as described in the content?
What does shear strain measure according to the experiment described?
What does shear strain measure according to the experiment described?
In the equation for shear strain, what does the symbol γ represent?
In the equation for shear strain, what does the symbol γ represent?
What is the relationship between the velocity of the top layer and the shear strain rate?
What is the relationship between the velocity of the top layer and the shear strain rate?
Which of the following correctly describes shear stress units?
Which of the following correctly describes shear stress units?
What does shear strain rate indicate?
What does shear strain rate indicate?
In the given context, which factor is directly involved in determining shear stress?
In the given context, which factor is directly involved in determining shear stress?
Which of the following terms is associated with the definition of shear strain?
Which of the following terms is associated with the definition of shear strain?
What is the behavior of materials that exhibit viscoelasticity under certain stress conditions?
What is the behavior of materials that exhibit viscoelasticity under certain stress conditions?
What physical property allows viscoelastic materials to prevent sedimentation during storage?
What physical property allows viscoelastic materials to prevent sedimentation during storage?
What is the phase angle for perfectly elastic materials?
What is the phase angle for perfectly elastic materials?
What happens to a viscoelastic material when a certain shear stress is applied?
What happens to a viscoelastic material when a certain shear stress is applied?
Which statement best describes the behavior of viscoelastic materials during application?
Which statement best describes the behavior of viscoelastic materials during application?
In what scenario do viscoelastic materials typically show liquid-like behavior?
In what scenario do viscoelastic materials typically show liquid-like behavior?
What does shear rate refer to in the context of viscoelastic materials?
What does shear rate refer to in the context of viscoelastic materials?
How do viscoelastic materials behave when concentrated suspensions are present?
How do viscoelastic materials behave when concentrated suspensions are present?
What factor is directly associated with an increase in viscosity?
What factor is directly associated with an increase in viscosity?
Which statement describes a Newtonian fluid?
Which statement describes a Newtonian fluid?
What is thixotropic behavior in fluids?
What is thixotropic behavior in fluids?
How is shear stress related to shear rate in Newtonian fluids?
How is shear stress related to shear rate in Newtonian fluids?
What is an example of a Newtonian fluid?
What is an example of a Newtonian fluid?
Which term best describes a fluid whose viscosity decreases with increased shear rate?
Which term best describes a fluid whose viscosity decreases with increased shear rate?
What happens to viscosity when temperature decreases in fluids?
What happens to viscosity when temperature decreases in fluids?
What is the relationship between shear stress and the rate of shear in a Newtonian system?
What is the relationship between shear stress and the rate of shear in a Newtonian system?
What is the unit of dynamic viscosity in the SI system?
What is the unit of dynamic viscosity in the SI system?
What characterizes Newtonian flow?
What characterizes Newtonian flow?
In the context of viscosity, what does 'mPas' stand for?
In the context of viscosity, what does 'mPas' stand for?
What type of flow is described by a tube viscometer?
What type of flow is described by a tube viscometer?
What physical property does viscosity relate to in a fluid?
What physical property does viscosity relate to in a fluid?
Which equation describes the relationship between shear stress and shear rate?
Which equation describes the relationship between shear stress and shear rate?
What is indicated by the term 'normalized value of viscosity'?
What is indicated by the term 'normalized value of viscosity'?
In the study of fluids, what is the significance of shear stress?
In the study of fluids, what is the significance of shear stress?
What is the expected outcome of using particle size reduction in powder mixing?
What is the expected outcome of using particle size reduction in powder mixing?
What is a critical factor to control in the crystallization process to ensure optimal drug distribution?
What is a critical factor to control in the crystallization process to ensure optimal drug distribution?
What metric is commonly analyzed to determine the uniformity of drug content in randomized samples?
What metric is commonly analyzed to determine the uniformity of drug content in randomized samples?
Which practice is recommended to prevent issues during powder mixing operations?
Which practice is recommended to prevent issues during powder mixing operations?
What is a consequence of particle agglomeration in a powder mixture?
What is a consequence of particle agglomeration in a powder mixture?
What is the primary aim of powder mixing?
What is the primary aim of powder mixing?
Which type of mixing involves adding a liquid binder to the powders?
Which type of mixing involves adding a liquid binder to the powders?
Which of the following statements best describes the impact of mixing on dosage forms?
Which of the following statements best describes the impact of mixing on dosage forms?
What is the purpose of pre-mixing in powder mixing?
What is the purpose of pre-mixing in powder mixing?
Which type of mixer is specifically designed for free-flowing powders?
Which type of mixer is specifically designed for free-flowing powders?
What is the primary reason for maintaining an optimal loading ratio in mixers?
What is the primary reason for maintaining an optimal loading ratio in mixers?
Which mechanism refers to the random movement of individual particles within a powder system?
Which mechanism refers to the random movement of individual particles within a powder system?
Why is it important to avoid particle segregation during mixing?
Why is it important to avoid particle segregation during mixing?
Which loading ratio is preferred for convective mixers?
Which loading ratio is preferred for convective mixers?
What is a significant concern when using fluidized bed mixers?
What is a significant concern when using fluidized bed mixers?
What factor can significantly increase the risk of explosion during mixing?
What factor can significantly increase the risk of explosion during mixing?
What mixing mechanism is described as the transfer of groups of particles?
What mixing mechanism is described as the transfer of groups of particles?
Which consequence can arise from improper mixing due to particle attrition?
Which consequence can arise from improper mixing due to particle attrition?
What is a significant disadvantage of using a Y-cone or cylinder for mixing particles?
What is a significant disadvantage of using a Y-cone or cylinder for mixing particles?
When using convective mixers, which of the following is a notable drawback?
When using convective mixers, which of the following is a notable drawback?
In terms of mixing functionality, what is an advantage of using a Y-cone or cylinder?
In terms of mixing functionality, what is an advantage of using a Y-cone or cylinder?
What main feature distinguishes impaction and high shear mixers from other types?
What main feature distinguishes impaction and high shear mixers from other types?
What does the use of internal impellers or prongs in a mixer primarily aim to reduce?
What does the use of internal impellers or prongs in a mixer primarily aim to reduce?
One major disadvantage of convective mixers is related to:
One major disadvantage of convective mixers is related to:
Fluidized bed mixers utilize what phenomenon to enhance powder mobility?
Fluidized bed mixers utilize what phenomenon to enhance powder mobility?
What is a common misconception regarding the use of high shear mixers?
What is a common misconception regarding the use of high shear mixers?
Which mixing mechanism is primarily utilized by low shear blade/paddle mixers?
Which mixing mechanism is primarily utilized by low shear blade/paddle mixers?
What characterizes a perfect mix compared to a random mix?
What characterizes a perfect mix compared to a random mix?
What is a primary factor that can affect segregation in powder mixtures?
What is a primary factor that can affect segregation in powder mixtures?
Which characteristics would define an interactive powder mixture?
Which characteristics would define an interactive powder mixture?
In a perfect mixture of 100 particles in a 50:50 ratio, what is the probability of achieving a perfect mix?
In a perfect mixture of 100 particles in a 50:50 ratio, what is the probability of achieving a perfect mix?
Which type of mixer is best suited for very cohesive and agglomerated powders?
Which type of mixer is best suited for very cohesive and agglomerated powders?
What action should be taken if segregation is identified as a problem during powder mixing?
What action should be taken if segregation is identified as a problem during powder mixing?
Which factor does NOT affect particle segregation during mixing?
Which factor does NOT affect particle segregation during mixing?
Flashcards
Rheology
Rheology
The science that studies how materials deform and flow under stress and strain.
Viscometry
Viscometry
A test that measures a fluid's resistance to flow.
Importance of Rheology
Importance of Rheology
Rheological measurements help classify and characterize materials, providing insights into viscosity (thickness), elasticity (stretchability), and viscoelasticity (combination of both).
Applications of Rheology
Applications of Rheology
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Quality Control in Rheology
Quality Control in Rheology
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Rheology and Product Problems
Rheology and Product Problems
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Process Optimization with Rheology
Process Optimization with Rheology
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Selecting Suitable Processing Methods
Selecting Suitable Processing Methods
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Shear Stress
Shear Stress
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Shear Strain
Shear Strain
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Shear Strain Rate
Shear Strain Rate
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Viscosity
Viscosity
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Rotational Viscometry
Rotational Viscometry
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Capillary Viscometry
Capillary Viscometry
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Falling Ball Viscometry
Falling Ball Viscometry
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Dynamic Viscosity
Dynamic Viscosity
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Newtonian Flow
Newtonian Flow
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Ostwald U-tube Viscometer
Ostwald U-tube Viscometer
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Storage Modulus (G')
Storage Modulus (G')
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Loss Modulus (G'')
Loss Modulus (G'')
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Viscoelasticity
Viscoelasticity
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Cox-Merz Rule
Cox-Merz Rule
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Complex Modulus
Complex Modulus
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Thixotropy
Thixotropy
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Newtonian Fluid
Newtonian Fluid
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Shear Rate
Shear Rate
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Flow Behavior
Flow Behavior
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Melting Point
Melting Point
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Pressure's Effect on Viscosity
Pressure's Effect on Viscosity
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Viscoelastic Materials
Viscoelastic Materials
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Yield Stress
Yield Stress
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Phase Angle
Phase Angle
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Time-dependent behavior (viscoelasticity)
Time-dependent behavior (viscoelasticity)
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Powder Mixing
Powder Mixing
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Dry Mixing
Dry Mixing
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Wet Mixing
Wet Mixing
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Pre-mixing
Pre-mixing
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Post-mixing
Post-mixing
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Y-cone mixer
Y-cone mixer
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Convective Mixer
Convective Mixer
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Impaction & High Shear Mixer
Impaction & High Shear Mixer
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Fluidised Bed Mixer
Fluidised Bed Mixer
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Particle Segregation in Y-cone Mixers
Particle Segregation in Y-cone Mixers
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Dead Spaces in Convective Mixers
Dead Spaces in Convective Mixers
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Particle Shattering in Impaction & High Shear Mixers
Particle Shattering in Impaction & High Shear Mixers
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Reduced Adhesion in Fluidised Bed Mixers
Reduced Adhesion in Fluidised Bed Mixers
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Diffusion (Powder Mixing)
Diffusion (Powder Mixing)
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Convection (Powder Mixing)
Convection (Powder Mixing)
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Shear (Powder Mixing)
Shear (Powder Mixing)
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Segregation (Powder Mixing)
Segregation (Powder Mixing)
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Loading Ratio (Powder Mixing)
Loading Ratio (Powder Mixing)
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Tumbling Mixer
Tumbling Mixer
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Diffusion
Diffusion
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Convection
Convection
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Shear
Shear
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Perfect mix
Perfect mix
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Random mix
Random mix
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Segregation
Segregation
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Granulation
Granulation
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High shear mixers
High shear mixers
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Effect of Large Drug Particles
Effect of Large Drug Particles
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Particle Size Reduction for Homogeneous Distribution
Particle Size Reduction for Homogeneous Distribution
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Particle Agglomeration and Poor Distribution
Particle Agglomeration and Poor Distribution
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Electrostatic Charging in Powder Mixing
Electrostatic Charging in Powder Mixing
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Best Practices for Powder Handling
Best Practices for Powder Handling
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Study Notes
Rheology
- Rheology is the science of deformation and flow.
- Viscometry testing measures a fluid's resistance to flow.
- Rheological measurements describe flow behavior of liquids and semi-solids.
- Insights into viscosity, elasticity, and viscoelasticity help understand material structure.
- Quality control involves assessing physical stability, consistency, compatibility, and bioavailability of materials.
- Rheology is also used to study flow behavior in various products.
Quality Control
- Physical stability and consistency are vital quality control aspects.
- Patient compatibility and drug bioavailability are also important.
- Variations in these properties can indicate contamination or poor mixing.
- Adhesive performance is a key quality control factor for transdermal patches.
- Process optimization involves understanding how materials behave under stress and strain, and selecting suitable equipment.
Product Development
- Optimizing flow, spreading, and firmness are key product development goals.
- Predicting material behavior under different conditions (temperature, pressure) is essential.
- Research and development explore materials' molecular structure, interactions, and new materials.
Newtonian Flow
- Newtonian fluids have constant viscosity regardless of applied shear stress.
- Resistance to flow doesn't change with speed or force of flow.
- Shear stress vs shear rate graph is linear.
- Gradient in the graph equals viscosity.
- Equipment for measuring Newtonian flow includes capillary viscometers and falling sphere viscometers.
- Examples of Newtonian fluids include water, petrol, glycerol, and hydrogen gas.
Non-Newtonian Flow
- Non-Newtonian fluids have viscosity that changes based on shear stress or strain rate.
- Shear-thinning fluids (e.g., cream) exhibit decreased viscosity with increasing shear rate.
- Shear-thickening fluids (e.g., concentrated suspensions) exhibit increased viscosity with increasing shear rate.
- Thixotropic fluids (e.g., bentonite, ketchup) exhibit time-dependent shear thinning behavior.
- Bingham flow has a yield stress before flowing like a Newtonian fluid.
- Non-Newtonian systems are also used across many products.
Viscoelasticity in Products
- Many materials exhibit viscoelasticity, behaving like viscous liquids in some processes and like elastic solids in others.
- During storage, the material needs to behave like a solid to prevent sedimentation.
- During application, it needs to behave like a fluid to flow smoothly (e.g., paints, creams, etc.).
Oscillation Principles
- Phase angle is a measure of elasticity and viscosity in materials.
- A higher phase angle indicates greater elasticity.
- A lower phase angle indicates greater viscosity.
- Purely elastic materials show stress and strain in phase.
- Purely viscous materials have stress and strain 90° out of phase.
Parameters in Oscillation
- Complex modulus and loss modulus relate to liquid- or solid-like characteristics of a sample.
- Dynamic viscosity is related to shear viscosity.
- Rheological behavior of cosmetic ingredients and finished products can be tested by rotational rheometers.
- Test modes include viscometry (shear), oscillation, creep, and recovery.
- Models such as the "wet sponge model" describe viscoelastic behaviors.
Oscillation Measurement Types
- Amplitude, frequency, and temperature sweeps are used to examine material properties under oscillation parameters.
- Unique fingerprints from amplitude sweeps reveal relative process time behavior.
- Creep tests apply constant stress over time to monitor resulting strains.
- Measuring time(t) is an important factor.
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