Rheology and Dynamic Viscosity Quiz

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Questions and Answers

What does the Dynamic Viscosity relate to in relation to shear?

  • Shear viscosity (correct)
  • Creep behavior
  • Elastic modulus
  • Phase angle

Which of the following test modes is NOT mentioned for rotational rheometers?

  • Steady shear (correct)
  • Oscillation
  • Creep
  • VisEometry

In complex viscoelastic behavior, the storage modulus indicates which property of a material?

  • Elastic limit
  • Liquid behavior
  • Solid nature (correct)
  • Viscous nature

What effect does adding water have on an elastic sample according to the content provided?

<p>Alters the sample to behave viscously (A)</p> Signup and view all the answers

What does the phrase 'Cox Merz rule' refer to in relation to dynamic viscosity?

<p>A relationship between steady shear and dynamic viscosity (C)</p> Signup and view all the answers

What does rheology study?

<p>The deformation and flow of materials (C)</p> Signup and view all the answers

What does viscometry test measure?

<p>The resistance of a fluid to flow (C)</p> Signup and view all the answers

Why are rheological measurements important?

<p>They describe flow behavior and consistency of materials (A)</p> Signup and view all the answers

Which aspect is NOT related to quality control in rheology?

<p>Chemical reaction rates (C)</p> Signup and view all the answers

What can inadequate mixing during production indicate?

<p>Contamination or poor mixing (D)</p> Signup and view all the answers

Which property is a key focus of rheological analysis?

<p>Viscosity and elasticity (A)</p> Signup and view all the answers

What is one reason for process optimization in rheology?

<p>To understand material behavior under stress and strains (B)</p> Signup and view all the answers

Which of the following is critical for the assessment of raw materials?

<p>Viscoelastic properties (B)</p> Signup and view all the answers

What is the formula for shear stress as described in the content?

<p>Force/Area (B)</p> Signup and view all the answers

What does shear strain measure according to the experiment described?

<p>Displacement caused by stress (D)</p> Signup and view all the answers

In the equation for shear strain, what does the symbol γ represent?

<p>Displacement/Height (C)</p> Signup and view all the answers

What is the relationship between the velocity of the top layer and the shear strain rate?

<p>Shear strain rate is directly proportional to velocity (A)</p> Signup and view all the answers

Which of the following correctly describes shear stress units?

<p>Newton per square meter (N/m²) (A)</p> Signup and view all the answers

What does shear strain rate indicate?

<p>Rate of deformation over time (D)</p> Signup and view all the answers

In the given context, which factor is directly involved in determining shear stress?

<p>Area of force application (C)</p> Signup and view all the answers

Which of the following terms is associated with the definition of shear strain?

<p>Displacement in a certain time frame (C)</p> Signup and view all the answers

What is the behavior of materials that exhibit viscoelasticity under certain stress conditions?

<p>They exhibit both solid-like and liquid-like properties. (A)</p> Signup and view all the answers

What physical property allows viscoelastic materials to prevent sedimentation during storage?

<p>Solid-like behavior (A)</p> Signup and view all the answers

What is the phase angle for perfectly elastic materials?

<p>0 degrees (C)</p> Signup and view all the answers

What happens to a viscoelastic material when a certain shear stress is applied?

<p>It begins to deform without flow. (D)</p> Signup and view all the answers

Which statement best describes the behavior of viscoelastic materials during application?

<p>They behave like solids to prevent flow. (C)</p> Signup and view all the answers

In what scenario do viscoelastic materials typically show liquid-like behavior?

<p>During the application process where flow is needed. (A)</p> Signup and view all the answers

What does shear rate refer to in the context of viscoelastic materials?

<p>The rate at which the material is deformed. (B)</p> Signup and view all the answers

How do viscoelastic materials behave when concentrated suspensions are present?

<p>They need to flow to maintain uniformity. (C)</p> Signup and view all the answers

What factor is directly associated with an increase in viscosity?

<p>Pressure (A)</p> Signup and view all the answers

Which statement describes a Newtonian fluid?

<p>Viscosity remains constant regardless of shear stress. (A)</p> Signup and view all the answers

What is thixotropic behavior in fluids?

<p>Viscosity decreases over time. (C)</p> Signup and view all the answers

How is shear stress related to shear rate in Newtonian fluids?

<p>They are proportional with a constant ratio. (A)</p> Signup and view all the answers

What is an example of a Newtonian fluid?

<p>Water (C)</p> Signup and view all the answers

Which term best describes a fluid whose viscosity decreases with increased shear rate?

<p>Pseudoplastic (B)</p> Signup and view all the answers

What happens to viscosity when temperature decreases in fluids?

<p>Viscosity increases. (A)</p> Signup and view all the answers

What is the relationship between shear stress and the rate of shear in a Newtonian system?

<p>Directly proportional. (A)</p> Signup and view all the answers

What is the unit of dynamic viscosity in the SI system?

<p>Pascal second (D)</p> Signup and view all the answers

What characterizes Newtonian flow?

<p>Viscosity remains constant regardless of shear rate (B)</p> Signup and view all the answers

In the context of viscosity, what does 'mPas' stand for?

<p>Millipascal second (B)</p> Signup and view all the answers

What type of flow is described by a tube viscometer?

<p>Laminar flow (C)</p> Signup and view all the answers

What physical property does viscosity relate to in a fluid?

<p>Resistance to flow (D)</p> Signup and view all the answers

Which equation describes the relationship between shear stress and shear rate?

<p>Shear stress = Viscosity x Shear rate (C)</p> Signup and view all the answers

What is indicated by the term 'normalized value of viscosity'?

<p>Viscosity relative to a standard reference (B)</p> Signup and view all the answers

In the study of fluids, what is the significance of shear stress?

<p>It quantifies the internal resistance to shear deformation (A)</p> Signup and view all the answers

What is the expected outcome of using particle size reduction in powder mixing?

<p>It results in improved drug distribution. (C)</p> Signup and view all the answers

What is a critical factor to control in the crystallization process to ensure optimal drug distribution?

<p>Choosing excipients of similar density to the drug. (C)</p> Signup and view all the answers

What metric is commonly analyzed to determine the uniformity of drug content in randomized samples?

<p>Standard deviation (C)</p> Signup and view all the answers

Which practice is recommended to prevent issues during powder mixing operations?

<p>Limiting transfers between different equipment. (C)</p> Signup and view all the answers

What is a consequence of particle agglomeration in a powder mixture?

<p>Deteriorated drug distribution. (A)</p> Signup and view all the answers

What is the primary aim of powder mixing?

<p>To achieve a homogeneous distribution of the single components in the powder bulk (A)</p> Signup and view all the answers

Which type of mixing involves adding a liquid binder to the powders?

<p>Wet mixing (C)</p> Signup and view all the answers

Which of the following statements best describes the impact of mixing on dosage forms?

<p>It influences the homogeneity of drug distribution and mechanical properties. (C)</p> Signup and view all the answers

What is the purpose of pre-mixing in powder mixing?

<p>To prepare mixtures with less than 5% w/w drug before further processing (B)</p> Signup and view all the answers

Which type of mixer is specifically designed for free-flowing powders?

<p>Tumbler mixer (C)</p> Signup and view all the answers

What is the primary reason for maintaining an optimal loading ratio in mixers?

<p>To ensure adequate distribution of particles (D)</p> Signup and view all the answers

Which mechanism refers to the random movement of individual particles within a powder system?

<p>Diffusion (D)</p> Signup and view all the answers

Why is it important to avoid particle segregation during mixing?

<p>It maintains uniformity in the final product. (B)</p> Signup and view all the answers

Which loading ratio is preferred for convective mixers?

<p>50-80% (A)</p> Signup and view all the answers

What is a significant concern when using fluidized bed mixers?

<p>Excessive dust emission (A)</p> Signup and view all the answers

What factor can significantly increase the risk of explosion during mixing?

<p>Mixer speed (D)</p> Signup and view all the answers

What mixing mechanism is described as the transfer of groups of particles?

<p>Convection (C)</p> Signup and view all the answers

Which consequence can arise from improper mixing due to particle attrition?

<p>Reduced mixing efficiency (B)</p> Signup and view all the answers

What is a significant disadvantage of using a Y-cone or cylinder for mixing particles?

<p>Prone to particle segregation (D)</p> Signup and view all the answers

When using convective mixers, which of the following is a notable drawback?

<p>Presence of dead spaces (B)</p> Signup and view all the answers

In terms of mixing functionality, what is an advantage of using a Y-cone or cylinder?

<p>Enhances lubricant and glidant incorporation (A)</p> Signup and view all the answers

What main feature distinguishes impaction and high shear mixers from other types?

<p>Blades rotating at 2000-3000 rpm (A)</p> Signup and view all the answers

What does the use of internal impellers or prongs in a mixer primarily aim to reduce?

<p>Particle segregation (A)</p> Signup and view all the answers

One major disadvantage of convective mixers is related to:

<p>High shear caused by impellers (D)</p> Signup and view all the answers

Fluidized bed mixers utilize what phenomenon to enhance powder mobility?

<p>Buoyancy from a flowing gas stream (D)</p> Signup and view all the answers

What is a common misconception regarding the use of high shear mixers?

<p>They do not break particle aggregates (A)</p> Signup and view all the answers

Which mixing mechanism is primarily utilized by low shear blade/paddle mixers?

<p>Convection (A)</p> Signup and view all the answers

What characterizes a perfect mix compared to a random mix?

<p>Each particle lies adjacent to a particle of the other component (B)</p> Signup and view all the answers

What is a primary factor that can affect segregation in powder mixtures?

<p>Particle size (D)</p> Signup and view all the answers

Which characteristics would define an interactive powder mixture?

<p>Cohesive and fine powders (C)</p> Signup and view all the answers

In a perfect mixture of 100 particles in a 50:50 ratio, what is the probability of achieving a perfect mix?

<p>1 in 10^30 (D)</p> Signup and view all the answers

Which type of mixer is best suited for very cohesive and agglomerated powders?

<p>High shear mixers (B)</p> Signup and view all the answers

What action should be taken if segregation is identified as a problem during powder mixing?

<p>Select similar sized drug and excipient (B)</p> Signup and view all the answers

Which factor does NOT affect particle segregation during mixing?

<p>Chemical composition (A)</p> Signup and view all the answers

Flashcards

Rheology

The science that studies how materials deform and flow under stress and strain.

Viscometry

A test that measures a fluid's resistance to flow.

Importance of Rheology

Rheological measurements help classify and characterize materials, providing insights into viscosity (thickness), elasticity (stretchability), and viscoelasticity (combination of both).

Applications of Rheology

Rheology is essential for understanding how materials behave during processing and how they perform in their final applications.

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Quality Control in Rheology

Rheological measurements help ensure the quality and consistency of finished products, reducing manufacturing variations and improving product performance.

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Rheology and Product Problems

Rheology can indicate the presence of contaminants, poor mixing, or other issues that can affect product quality.

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Process Optimization with Rheology

Rheology plays a crucial role in designing optimal processing conditions for various materials, ensuring efficiency and quality.

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Selecting Suitable Processing Methods

By understanding the rheological behavior of materials, engineers and scientists can choose the most suitable processing methods for desired product characteristics.

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Shear Stress

The force applied parallel to a surface divided by the area of the surface. It measures the force per unit area that causes deformation.

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Shear Strain

The ratio of the displacement of a layer to its distance from the fixed layer. It measures the amount of deformation caused by shear stress.

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Shear Strain Rate

The rate of change of shear strain. It measures how quickly the deformation is happening.

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Viscosity

The ratio of shear stress to shear strain rate. It measures the fluid's resistance to flow.

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Rotational Viscometry

A type of viscometry that measures viscosity by applying a known force to a rotating object and measuring the resulting angular velocity.

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Capillary Viscometry

A type of viscometry that measures viscosity by measuring the flow rate of a fluid through a capillary tube.

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Falling Ball Viscometry

A type of viscometry that measures viscosity by measuring the time it takes for a known volume of fluid to fall through a narrow tube.

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Dynamic Viscosity

A measure of a fluid's resistance to flow. Higher viscosity means the fluid flows slower. It's measured in Pascal-seconds (Pa·s) or Poise (P).

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Newtonian Flow

A fluid's resistance to flow is directly proportional to the shear rate. Doubling the shear rate doubles the resistance.

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Ostwald U-tube Viscometer

A type of viscometer where a fluid flows through a tube under the influence of gravity. The flow time is measured to determine viscosity.

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Storage Modulus (G')

A measure of a material's resistance to deformation under stress. It reflects how stiff or flexible the material is.

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Loss Modulus (G'')

Describes a material's ability to deform when subjected to a constant stress. It reflects how well the material can flow or creep.

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Viscoelasticity

A property of materials that exhibit both viscous and elastic behavior. It combines the characteristics of solids and liquids.

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Cox-Merz Rule

A rule that relates the complex viscosity of a material to its frequency-dependent storage and loss moduli.

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Complex Modulus

A mathematical model that describes the behavior of viscoelastic materials under stress. It involves complex moduli that represent both elastic and viscous components.

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Thixotropy

The tendency of a fluid to decrease in viscosity over time under constant shear stress.

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Newtonian Fluid

Fluids that have a constant viscosity regardless of the applied shear stress.

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Shear Rate

The rate at which a fluid is deformed under shear stress.

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Flow Behavior

The relationship between shear stress and shear rate.

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Melting Point

The temperature at which a substance transitions from a solid to a liquid.

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Pressure's Effect on Viscosity

Viscosity increases with increasing pressure.

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Viscoelastic Materials

Materials that exhibit both elastic and viscous behavior. They can deform under stress and return to their original shape but also flow over time.

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Yield Stress

The point at which a material starts to flow when subjected to increasing shear stress. This is the threshold beyond which the material behaves like a liquid.

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Phase Angle

The angle between the stress and strain in a material under applied force. For purely elastic materials, this angle is 0 degrees.

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Time-dependent behavior (viscoelasticity)

A material's response to stress and strain can change depending on how quickly the stress is applied. This is a key factor in understanding material behavior in various applications.

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Powder Mixing

A process where two or more dry powder components are mixed to achieve uniform distribution of each component throughout the mixture. This ensures every particle of one component is as close as possible to a particle of every other component.

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Dry Mixing

A type of powder mixing where no liquid is added during the process. The powders are mixed in their dry state.

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Wet Mixing

A type of powder mixing where a liquid binder is added to the powder mixture. This leads to the formation of granules, improving flowability and handling properties.

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Pre-mixing

A type of powder mixing used for mixtures where the active ingredient (drug) is present at low concentrations (less than 5% by weight). The mixing process is often followed by deagglomeration using a sieve to ensure fine and homogeneous distribution.

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Post-mixing

This mixing occurs after the main powder mixture is prepared and involves adding additional components like lubricants or glidants to improve processing properties. It usually involves short mixing times (3-5 minutes).

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Y-cone mixer

A type of powder mixer where particles tumble over each other due to rotation, promoting good mixing.

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Convective Mixer

A type of powder mixer with a fixed vessel and an internal impeller that moves powder groups, reducing fine particle segregation.

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Impaction & High Shear Mixer

A powder mixer with a rotating impeller that creates centrifugal forces, increasing energy input and breaking aggregates. Used after convective or tumbling mixing.

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Fluidised Bed Mixer

A type of powder mixer where powder is subjected to a flowing gas stream, allowing particles to float and enhancing mobility.

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Particle Segregation in Y-cone Mixers

A disadvantage of Y-cone mixers. Larger particles tend to settle at the bottom, leading to uneven mixing.

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Dead Spaces in Convective Mixers

A potential problem with convective mixers. Areas in the mixer where powder movement is minimal, resulting in uneven mixing.

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Particle Shattering in Impaction & High Shear Mixers

A risk with impaction & high shear mixers. Excessive force can break powder particles, impacting their size and properties.

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Reduced Adhesion in Fluidised Bed Mixers

A benefit of using fluidised bed mixers. The flowing gas stream reduces the risk of powder sticking to mixer surfaces.

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Diffusion (Powder Mixing)

The process where individual particles in a powder mix move randomly, contributing to a more homogeneous blend.

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Convection (Powder Mixing)

The movement of groups of particles in a powder mixture, creating larger-scale mixing.

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Shear (Powder Mixing)

Layers of particles in a powder mixture slide over each other, causing mixing due to this relative motion.

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Segregation (Powder Mixing)

The tendency for particles of different sizes, shapes, or densities to separate during mixing.

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Loading Ratio (Powder Mixing)

The ratio of the volume of powder to the volume of the mixing vessel. This affects how well the powder can move and mix.

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Tumbling Mixer

A type of mixer where powder tumbles and mixes due to gravity and the movement of the vessel.

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Diffusion

The movement of individual particles due to random motion, usually in gases or liquids.

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Convection

The movement of groups of particles, often driven by temperature differences. Think of hot air rising.

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Shear

The movement of particles by sliding over each other along specific planes within a material.

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Perfect mix

A mixture where each particle of one component is surrounded by particles of the other component, essentially the ideal mix.

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Random mix

A mixture with a random distribution of particles, where the chance of finding a specific component is equal throughout the mixture.

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Segregation

The tendency for components in a powder mixture to separate based on differences in properties like size, density, or shape.

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Granulation

A powder formulation method where small particles are bonded together to form larger particles, improving flow properties and reducing segregation.

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High shear mixers

Mixers that use high shear forces to break down cohesive particles and distribute them evenly, suitable for very cohesive powders.

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Effect of Large Drug Particles

Large particles of the drug lead to uneven distribution throughout the powder mixture, resulting in inconsistent dosing.

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Particle Size Reduction for Homogeneous Distribution

Reducing the size of drug particles improves their distribution in the mixture, ensuring greater homogeneity in the final product.

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Particle Agglomeration and Poor Distribution

Agglomeration of particles (clumps) creates uneven distribution, making it difficult to achieve a uniform mix.

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Electrostatic Charging in Powder Mixing

Electrostatic charging can make powders cling together and become difficult to mix. Using materials that minimize surface contact can help reduce this effect.

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Best Practices for Powder Handling

Powder handling during mixing should be efficient, minimizing transfers and vibrations. This helps maintain uniformity and prevent segregation.

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Study Notes

Rheology

  • Rheology is the science of deformation and flow.
  • Viscometry testing measures a fluid's resistance to flow.
  • Rheological measurements describe flow behavior of liquids and semi-solids.
  • Insights into viscosity, elasticity, and viscoelasticity help understand material structure.
  • Quality control involves assessing physical stability, consistency, compatibility, and bioavailability of materials.
  • Rheology is also used to study flow behavior in various products.

Quality Control

  • Physical stability and consistency are vital quality control aspects.
  • Patient compatibility and drug bioavailability are also important.
  • Variations in these properties can indicate contamination or poor mixing.
  • Adhesive performance is a key quality control factor for transdermal patches.
  • Process optimization involves understanding how materials behave under stress and strain, and selecting suitable equipment.

Product Development

  • Optimizing flow, spreading, and firmness are key product development goals.
  • Predicting material behavior under different conditions (temperature, pressure) is essential.
  • Research and development explore materials' molecular structure, interactions, and new materials.

Newtonian Flow

  • Newtonian fluids have constant viscosity regardless of applied shear stress.
  • Resistance to flow doesn't change with speed or force of flow.
  • Shear stress vs shear rate graph is linear.
  • Gradient in the graph equals viscosity.
  • Equipment for measuring Newtonian flow includes capillary viscometers and falling sphere viscometers.
  • Examples of Newtonian fluids include water, petrol, glycerol, and hydrogen gas.

Non-Newtonian Flow

  • Non-Newtonian fluids have viscosity that changes based on shear stress or strain rate.
  • Shear-thinning fluids (e.g., cream) exhibit decreased viscosity with increasing shear rate.
  • Shear-thickening fluids (e.g., concentrated suspensions) exhibit increased viscosity with increasing shear rate.
  • Thixotropic fluids (e.g., bentonite, ketchup) exhibit time-dependent shear thinning behavior.
  • Bingham flow has a yield stress before flowing like a Newtonian fluid.
  • Non-Newtonian systems are also used across many products.

Viscoelasticity in Products

  • Many materials exhibit viscoelasticity, behaving like viscous liquids in some processes and like elastic solids in others.
  • During storage, the material needs to behave like a solid to prevent sedimentation.
  • During application, it needs to behave like a fluid to flow smoothly (e.g., paints, creams, etc.).

Oscillation Principles

  • Phase angle is a measure of elasticity and viscosity in materials.
  • A higher phase angle indicates greater elasticity.
  • A lower phase angle indicates greater viscosity.
  • Purely elastic materials show stress and strain in phase.
  • Purely viscous materials have stress and strain 90° out of phase.

Parameters in Oscillation

  • Complex modulus and loss modulus relate to liquid- or solid-like characteristics of a sample.
  • Dynamic viscosity is related to shear viscosity.
  • Rheological behavior of cosmetic ingredients and finished products can be tested by rotational rheometers.
  • Test modes include viscometry (shear), oscillation, creep, and recovery.
  • Models such as the "wet sponge model" describe viscoelastic behaviors.

Oscillation Measurement Types

  • Amplitude, frequency, and temperature sweeps are used to examine material properties under oscillation parameters.
  • Unique fingerprints from amplitude sweeps reveal relative process time behavior.
  • Creep tests apply constant stress over time to monitor resulting strains.
  • Measuring time(t) is an important factor.

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