Rhabdoviruses: Rabies and Epidemiology

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What is the shape of the virions of Rhabdoviruses?

Helical
Bullet-shaped (correct)
Spherical
Fibrous

What is the primary reservoir of Rhabdoviruses?

Wild mammals (correct)
Insects
Humans
Domestic animals

What is the duration of the incubation period of Rabies?

1-7 days
1-90 days
1 day to years (correct)
1-10 years

What is the characteristic inclusion body found in infected neurons in Rabies?

Negri body (A) Signup and view all the answers

What is the form of Rabies that accounts for 80% of patients?

Furious form (C) Signup and view all the answers

What is the approximate number of deaths due to Rabies worldwide?

59,000 (B) Signup and view all the answers

What is the estimated percentage of risk reduction through wound cleaning and care for rabies treatment?

90% (C) Signup and view all the answers

What is the primary target of coronaviruses during infection?

Epithelial cells (A) Signup and view all the answers

What is the name of the vaccine used for post-exposure prophylaxis of rabies?

All of the above (D) Signup and view all the answers

What is the typical duration of the incubation period for SARS-CoV-2?

4-5 days (B) Signup and view all the answers

What is the estimated percentage of adults seropositive to common respiratory strains of coronaviruses?

90% (C) Signup and view all the answers

What is the optimal temperature for coronavirus replication?

33-35°C (A) Signup and view all the answers

What is the percentage of hospitalized COVID-19 patients with underlying medical conditions?

90% (A) Signup and view all the answers

What is the name of the virus responsible for Middle East Respiratory Syndrome (MERS)?

MERS-CoV (D) Signup and view all the answers

What is the primary mode of transmission for SARS-CoV-2?

Respiratory secretions (A) Signup and view all the answers

What is the percentage of fatalities among SARS and MERS cases?

9% (B) Signup and view all the answers

What percentage of identified patients experienced fever, cough, or shortness of breath?

70% (D) Signup and view all the answers

What is the mean incubation period of SARS-CoV-2?

4-5 days (A) Signup and view all the answers

What is the percentage of patients who are asymptomatic?

??% (A) Signup and view all the answers

What is the treatment for hospitalized patients requiring supplemental oxygen?

Corticosteroids (C) Signup and view all the answers

What is the name of the vaccine that expressing Spike protein?

mRNA nanoparticles (D) Signup and view all the answers

What is the consequence of rubella infection during the first trimester of pregnancy?

Miscarriage or multiple defects (A) Signup and view all the answers

What is the characteristic of Flaviviruses?

Highly structured 5’ and 3’ UTRs (B) Signup and view all the answers

What is the size of Hepatitis C virus particles?

30-60 nm (A) Signup and view all the answers

What is the error prone feature of Hepatitis C virus polymerase?

Highly error prone (D) Signup and view all the answers

What is the type of endocytosis that Flaviviruses enter via?

Receptor mediated endocytosis (C) Signup and view all the answers

What is the function of NS3 protein in Hepatitis C Virus?

Serine protease required for cleavage of polyprotein (B) Signup and view all the answers

How is Hepatitis C Virus primarily acquired?

Through blood contact, such as blood transfusions and needle sharing (A) Signup and view all the answers

What percentage of people with Hepatitis C Virus will remain infected indefinitely?

75-85% (D) Signup and view all the answers

What is the target of the drug Sofosbuvir?

NS5B polymerase (D) Signup and view all the answers

What is the cost of the 12-week regimen of Glecaprevir-Pibrentasvir?

$26,400 (B) Signup and view all the answers

What is the primary mechanism of transmission of Arboviruses?

Vector-borne transmission through arthropods (C) Signup and view all the answers

What is the typical incubation period of Acute Arbovirus Infections?

4-7 days (D) Signup and view all the answers

What is the common complication of Acute Arbovirus Infections?

Viral encephalitis (B) Signup and view all the answers

What is the role of humans in the life cycle of Arboviruses?

All of the above (D) Signup and view all the answers

What is the result of controlling the vector in Arbovirus infections?

Decreased transmission of the virus (A) Signup and view all the answers

What is the primary mode of transmission of Zika virus to humans?

Through the bite of an infected Aedes species mosquito (B) Signup and view all the answers

Which of the following viruses is commonly associated with congenital microcephaly?

Zika virus (B) Signup and view all the answers

What is the typical incubation period for Chikungunya virus?

3-7 days (A) Signup and view all the answers

What is the name of the vaccine used to prevent Dengue fever?

Dengvaxia (B) Signup and view all the answers

Which of the following viruses is carried by Culex mosquitoes?

West Nile virus (C) Signup and view all the answers

What is the main mechanism of error generation during retroviral replication?

Nucleotide misincorporation (B) Signup and view all the answers

What is the estimated percentage of asymptomatic West Nile virus infections?

70-80% (D) Signup and view all the answers

Which of the following viruses is associated with Guillain-Barré syndrome?

Zika virus (D) Signup and view all the answers

What is the primary mechanism of retroviral replication?

Conversion of ssRNA genome to dsDNA (B) Signup and view all the answers

What is the typical duration of symptoms for Chikungunya virus infection?

7-10 days (A) Signup and view all the answers