Rh Blood Group System Overview

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Questions and Answers

What percentage of humans are considered Rh positive?

  • 50%
  • 20%
  • 90%
  • 80% (correct)

What happens if an Rh negative person is exposed to Rh positive blood?

  • They experience jaundice
  • They form antibodies against Rh antigens (correct)
  • They develop anemia
  • They become Rh positive

What is the term used for the condition where Rh negative mother's antibodies attack the Rh positive baby's red blood cells?

  • Erythrocytosis
  • Thalassemia
  • Erythroblastosis fetalis (correct)
  • Hemolytic anemia

Why should the Rh group be matched before transfusions?

<p>To avoid antibody formation (A)</p> Signup and view all the answers

In which pregnancy does the mother get exposed to the Rh positive blood of the fetus?

<p>First pregnancy (C)</p> Signup and view all the answers

What can be fatal to the fetus in cases of Rh incompatibility?

<p>Hyperbilirubinemia (D)</p> Signup and view all the answers

How can erythroblastosis fetalis be prevented?

<p>Administering anti-Rh antibodies to the mother after every pregnancy (C)</p> Signup and view all the answers

What is the role of the placenta in preventing Rh exposure during the first pregnancy?

<p>It acts as a barrier preventing direct contact between maternal and fetal blood. (D)</p> Signup and view all the answers

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Study Notes

Rh Grouping

  • Rh antigen, similar to one found in Rhesus monkeys, is present on the surface of RBCs in nearly 80% of humans, making them Rh positive (Rh+ve).
  • Individuals without the Rh antigen are Rh negative (Rh-ve).
  • Rh-ve individuals will form antibodies against Rh antigens if exposed to Rh+ve blood, making Rh matching necessary for transfusions.

Rh Incompatibility

  • In pregnancy, Rh-ve mothers with Rh+ve foetuses can experience Rh incompatibility due to placental separation of blood during the first pregnancy.
  • During delivery, small amounts of Rh+ve blood from the foetus may enter the mother's bloodstream, triggering antibody production against Rh antigens.
  • In subsequent pregnancies, these Rh antibodies from the mother can leak into the foetus's blood, destroying RBCs and causing:
    • Erythroblastosis foetalis, a potentially fatal condition for the foetus.
    • Severe anaemia and jaundice in the baby.

Prevention

  • Administering anti-Rh antibodies to the Rh-ve mother immediately after the first child's delivery can prevent Rh incompatibility issues in subsequent pregnancies.

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