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RH Alloimmunization and Hemolytic Disease

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RH Alloimmunization and Hemolytic Disease

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Questions and Answers

What can cause sensitization in pregnancy?

Umbilical cord compression

Delivery (correct)

Normal uterine contractions

Placenta previa

What is the purpose of repeating the Rh titer at 28 weeks in a non-sensitized mother?

To monitor for sensitization (correct)

To determine the Rh type of the fetus

To determine the mode of delivery

To assess the severity of anemia

What is the next step in management if the fetus is at risk of HDFN?

Administer Rh immune globulin

Repeat the indirect Coombs test

Assess the severity of anemia starting from 16-18 weeks (correct)

Perform an emergency cesarean section

What is the purpose of performing a direct Coombs test?

To diagnose HDFN in the fetus Signup and view all the answers

What is the significance of a positive indirect Coombs test?

The fetus is at risk of HDFN Signup and view all the answers

What is the purpose of knowing the Rh type of the fetus in a sensitized mother?

To determine if the fetus is at risk of HDFN Signup and view all the answers

What is the management for fetal anemia with a Middle Cerebral Artery Peak Systolic Velocity (MCA PSV) greater than 1.5 MoM?

Intrauterine transfusion Signup and view all the answers

What is the primary goal of administering Anti-D immune globulin in Rh alloimmunization?

To prevent the immune response in the mother Signup and view all the answers

What is the recommended dosage of Anti-D immune globulin for routine antenatal administration at 28 weeks?

300mcg Signup and view all the answers

What is the recommended time frame for administering Anti-D immune globulin after a potentially sensitizing event?

Within 72 hours Signup and view all the answers

What is the primary source of Anti-D immune globulin?

Donor plasma Signup and view all the answers

What is the benefit of Anti-D immune globulin administration in preventing Rh alloimmunization?

Reduces the risk from 1-2% to 0.1-0.3% Signup and view all the answers

What is the primary cause of fetal hemolysis in Rh alloimmunization?

Immune reaction due to Ag-Ab interaction Signup and view all the answers

What is the condition in which transplacental passage of maternal IgG results in immune hemolysis of fetal/neonatal red cells?

Hemolytic disease of the fetus and newborn Signup and view all the answers

What is the result of fetomaternal hemorrhage (FMH) in an Rh-negative mother?

IgG production in the mother Signup and view all the answers

What is a common sequela of hemolysis in Rh alloimmunization?

Hyperbilirubinemia Signup and view all the answers

What is the definition of fetal hydrops?

Presence of 2 or more abnormal fetal fluid collections Signup and view all the answers

What is the result of the second exposure to the Rh antigen in an Rh-negative mother?

All of the above Signup and view all the answers