18 Questions
What can cause sensitization in pregnancy?
Delivery
What is the purpose of repeating the Rh titer at 28 weeks in a non-sensitized mother?
To monitor for sensitization
What is the next step in management if the fetus is at risk of HDFN?
Assess the severity of anemia starting from 16-18 weeks
What is the purpose of performing a direct Coombs test?
To diagnose HDFN in the fetus
What is the significance of a positive indirect Coombs test?
The fetus is at risk of HDFN
What is the purpose of knowing the Rh type of the fetus in a sensitized mother?
To determine if the fetus is at risk of HDFN
What is the management for fetal anemia with a Middle Cerebral Artery Peak Systolic Velocity (MCA PSV) greater than 1.5 MoM?
Intrauterine transfusion
What is the primary goal of administering Anti-D immune globulin in Rh alloimmunization?
To prevent the immune response in the mother
What is the recommended dosage of Anti-D immune globulin for routine antenatal administration at 28 weeks?
300mcg
What is the recommended time frame for administering Anti-D immune globulin after a potentially sensitizing event?
Within 72 hours
What is the primary source of Anti-D immune globulin?
Donor plasma
What is the benefit of Anti-D immune globulin administration in preventing Rh alloimmunization?
Reduces the risk from 1-2% to 0.1-0.3%
What is the primary cause of fetal hemolysis in Rh alloimmunization?
Immune reaction due to Ag-Ab interaction
What is the condition in which transplacental passage of maternal IgG results in immune hemolysis of fetal/neonatal red cells?
Hemolytic disease of the fetus and newborn
What is the result of fetomaternal hemorrhage (FMH) in an Rh-negative mother?
IgG production in the mother
What is a common sequela of hemolysis in Rh alloimmunization?
Hyperbilirubinemia
What is the definition of fetal hydrops?
Presence of 2 or more abnormal fetal fluid collections
What is the result of the second exposure to the Rh antigen in an Rh-negative mother?
All of the above
This quiz covers RH alloimmunization, its physiology, pathophysiology, diagnosis, management, and prevention, including fetal hydrops and hemolytic disease of the fetus and newborn.
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