Questions and Answers
What class does reteplase belong to?
What is the mechanism of action (MOA) of reteplase?
Prepared through recombinant DNA technology, reteplase acts by cleaving plasminogen to form plasmin, which degrades the fibrin matrix of thrombi.
What are the uses of reteplase?
Reteplase should be reconstituted immediately prior to use.
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Which of the following statements is true about reteplase administration alerts?
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What are some adverse effects of reteplase?
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How does reteplase affect lab tests?
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What is the treatment for reteplase overdose?
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Study Notes
Reteplase Overview
- Reteplase is classified as a thrombolytic agent, utilized primarily to dissolve blood clots.
Mechanism of Action
- Produced via recombinant DNA technology, reteplase cleaves plasminogen to generate plasmin.
- Plasmin effectively breaks down the fibrin matrix within thrombi, aiding in clot resolution.
Indications for Use
- Administered for symptoms of myocardial infarction (MI).
- Effective in treating deep vein thrombosis (DVT).
- Can be used to clear occluded catheters.
Administration Considerations
- Must be reconstituted right before administration with the manufacturer’s specified diluent; swirl gently to mix, avoiding shaking.
- Reteplase must not be co-administered with heparin due to incompatibility.
- No other medications should be infused through the same intravenous line.
Adverse Effects
- Main side effect is abnormal bleeding.
- Patients may experience dysrhythmias during the process of myocardial reperfusion.
Laboratory Interactions
- Reteplase degrades plasminogen in blood samples, leading to lower levels of serum plasminogen and fibrinogen.
Overdose Information
- There is no established treatment protocol for reteplase overdose.
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Description
Test your knowledge on reteplase with these flashcards. Learn about its classification, mechanism of action, uses, and administration alerts. Perfect for students studying pharmacology or healthcare professionals.
