15 Questions
What is the typical resting membrane potential (RMP) of a resting neuron?
-70 mV
What causes the generation of the resting membrane potential (RMP) in a cell?
Selective permeability of the cell membrane
Which type of tissues typically have a more negative resting membrane potential (RMP)?
Excitable tissues
What is the role of the Na+ and K+ pump in the generation of resting membrane potential?
Maintain the ionic distribution across the cell membrane
What is the main function of the Gibbs’-Donnan equilibrium potential in the genesis of resting membrane potential?
Equalize the concentrations of intracellular and extracellular ions
Which ion has a high concentration inside the cell compared to outside?
Potassium (K+)
What is the name of the equilibrium established when two solutions containing ions are separated by a membrane?
Electrochemical equilibrium
What does the Nernst potential (Equilibrium potential) determine?
The potential level across the membrane that will exactly prevent net diffusion of an ion
Which equation is used to calculate the equilibrium potential when the membrane is permeable to several ions?
Goldman Equation
What type of channels allow free flow of ions, with a larger number being K+ channels?
Leaky channels
What is the net effect of the Na+/K+ pump?
Causing negative charge inside the membrane
Which ion contributes more to the resting membrane potential (RMP) according to its efflux potential?
K+ (Potassium)
What contributes to the negativity of the resting membrane potential?
K+ efflux, Na+/K+ pump, and negatively charged protein ions inside the membrane
What is the main factor contributing to the negativity of the resting membrane potential?
K+ efflux
What does the Goldman Equation depend on when calculating the equilibrium potential for multiple ions?
Polarity of each ion, Membrane permeability, Ionic concentration
This quiz covers the concept of resting membrane potential, including the difference in electric potential across the cell membrane in a resting state, the potential difference across the membrane of a resting neuron, and the generation of potential difference by different ion concentrations. Additionally, it explores excitable tissues and their characteristic negative resting membrane potential.
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