Podcast
Questions and Answers
What is the primary function of alveoli in the respiratory system?
What is the primary function of alveoli in the respiratory system?
- To facilitate gas exchange between air and blood. (correct)
- To humidify air before it reaches the bronchi.
- To produce mucus that traps foreign particles.
- To filter air entering the lungs.
Which condition involves alveolar sacs filling with fluid, pus, or blood?
Which condition involves alveolar sacs filling with fluid, pus, or blood?
- Asthma
- Emphysema
- Pneumonia (correct)
- Pulmonary fibrosis
A patient's pulmonary function tests reveal significant difficulty exhaling. Which type of lung disease is most likely?
A patient's pulmonary function tests reveal significant difficulty exhaling. Which type of lung disease is most likely?
- Obstructive lung disease. (correct)
- Vascular lung disease.
- Restrictive lung disease.
- Infectious lung disease.
In restrictive lung disease, what change is typically observed in total lung capacity (TLC)?
In restrictive lung disease, what change is typically observed in total lung capacity (TLC)?
A patient with a V/Q ratio of 1.2 likely has a problem with:
A patient with a V/Q ratio of 1.2 likely has a problem with:
What does an arterial blood gas (ABG) with a pH of 7.32, PaCO2 of 52, HCO3- of 29, and PaO2 of 68 indicate in a COPD patient?
What does an arterial blood gas (ABG) with a pH of 7.32, PaCO2 of 52, HCO3- of 29, and PaO2 of 68 indicate in a COPD patient?
What is a key factor in the development of Bronchopulmonary Dysplasia (BPD) in premature infants?
What is a key factor in the development of Bronchopulmonary Dysplasia (BPD) in premature infants?
A premature infant requires mechanical ventilation and supplemental oxygen for several weeks. At 36 weeks gestational age, the infant still needs oxygen. Based on this information, what condition is the infant likely to be diagnosed with?
A premature infant requires mechanical ventilation and supplemental oxygen for several weeks. At 36 weeks gestational age, the infant still needs oxygen. Based on this information, what condition is the infant likely to be diagnosed with?
A baby with Bronchopulmonary Dysplasia (BPD) is likely to have which of the following clinical manifestations?
A baby with Bronchopulmonary Dysplasia (BPD) is likely to have which of the following clinical manifestations?
Which genetic inheritance pattern is associated with Cystic Fibrosis (CF)?
Which genetic inheritance pattern is associated with Cystic Fibrosis (CF)?
What is the primary defect in Cystic Fibrosis (CF) that leads to the disease's various manifestations?
What is the primary defect in Cystic Fibrosis (CF) that leads to the disease's various manifestations?
A newborn screening suggests possible Cystic Fibrosis (CF). What is the standard test to confirm the diagnosis?
A newborn screening suggests possible Cystic Fibrosis (CF). What is the standard test to confirm the diagnosis?
What is a common respiratory pathogen that colonizes the airways of individuals with Cystic Fibrosis (CF)?
What is a common respiratory pathogen that colonizes the airways of individuals with Cystic Fibrosis (CF)?
A child with Cystic Fibrosis has recurrent respiratory infections and greasy, foul-smelling stools. Which of the following is the most likely cause of the stool characteristics?
A child with Cystic Fibrosis has recurrent respiratory infections and greasy, foul-smelling stools. Which of the following is the most likely cause of the stool characteristics?
Which of the following genitourinary manifestations is most commonly associated with Cystic Fibrosis (CF) in males?
Which of the following genitourinary manifestations is most commonly associated with Cystic Fibrosis (CF) in males?
A patient presents with chronic cough, failure to thrive, and salty skin. Which condition does this presentation suggest?
A patient presents with chronic cough, failure to thrive, and salty skin. Which condition does this presentation suggest?
What characterizes Idiopathic Pulmonary Fibrosis (IPF)?
What characterizes Idiopathic Pulmonary Fibrosis (IPF)?
Which of the following is a common risk factor for developing Idiopathic Pulmonary Fibrosis?
Which of the following is a common risk factor for developing Idiopathic Pulmonary Fibrosis?
A patient with Idiopathic Pulmonary Fibrosis (IPF) is likely to have which finding on physical examination?
A patient with Idiopathic Pulmonary Fibrosis (IPF) is likely to have which finding on physical examination?
What is the typical prognosis for a patient diagnosed with Idiopathic Pulmonary Fibrosis (IPF)?
What is the typical prognosis for a patient diagnosed with Idiopathic Pulmonary Fibrosis (IPF)?
Exposure to which of the following substances is least likely to cause COPD?
Exposure to which of the following substances is least likely to cause COPD?
In the pathogenesis of chronic bronchitis and emphysema, what is the role of inflammation in the airway epithelium?
In the pathogenesis of chronic bronchitis and emphysema, what is the role of inflammation in the airway epithelium?
Which assessment finding is most indicative of COPD?
Which assessment finding is most indicative of COPD?
Which of the following is a key characteristic that differentiates pulmonary arterial hypertension (PAH) from pulmonary venous hypertension?
Which of the following is a key characteristic that differentiates pulmonary arterial hypertension (PAH) from pulmonary venous hypertension?
A patient with pulmonary hypertension would likely experience which of the following physiological changes?
A patient with pulmonary hypertension would likely experience which of the following physiological changes?
Which of the following is a common cause of pulmonary arterial hypertension?
Which of the following is a common cause of pulmonary arterial hypertension?
A patient with long-standing pulmonary hypertension develops right ventricular enlargement. Which condition is most likely to develop as a result?
A patient with long-standing pulmonary hypertension develops right ventricular enlargement. Which condition is most likely to develop as a result?
A nurse assessing a patient with suspected right heart failure would expect to find which of the following?
A nurse assessing a patient with suspected right heart failure would expect to find which of the following?
What is a key diagnostic indicator for cor pulmonale?
What is a key diagnostic indicator for cor pulmonale?
What are the general requirements for patients to be considered a candidate for lung transplantation?
What are the general requirements for patients to be considered a candidate for lung transplantation?
Which of the following represents a relative contraindication for lung transplantation?
Which of the following represents a relative contraindication for lung transplantation?
Which type of lung transplant involves a single lobe from a living donor?
Which type of lung transplant involves a single lobe from a living donor?
What is a leading cause of death following lung transplantation?
What is a leading cause of death following lung transplantation?
After a lung transplant, a patient experiences a gradual decline in pulmonary function with decreased spirometry readings. What complication is most likely occurring?
After a lung transplant, a patient experiences a gradual decline in pulmonary function with decreased spirometry readings. What complication is most likely occurring?
Which of the following is often asymptomatic following a lung transplant, and can only be detected with frequent PFTs?
Which of the following is often asymptomatic following a lung transplant, and can only be detected with frequent PFTs?
Which of the following is one of the two sources a lung can be harvested from for transplant?
Which of the following is one of the two sources a lung can be harvested from for transplant?
A right ventricular heave can be found in the later stages in a patient exhibiting signs of:
A right ventricular heave can be found in the later stages in a patient exhibiting signs of:
Which of the following tools cannot be used during initial confirmation of exertion dyspnea?
Which of the following tools cannot be used during initial confirmation of exertion dyspnea?
What is the standard age cut off for transplant qualification consideration?
What is the standard age cut off for transplant qualification consideration?
In alveolar sac pathology, what directly results from the sac's inability to fully deflate?
In alveolar sac pathology, what directly results from the sac's inability to fully deflate?
What would be expected in a patient with a restrictive lung disease?
What would be expected in a patient with a restrictive lung disease?
What characteristic ABG values would you expect to see in a patient who is alkalotic?
What characteristic ABG values would you expect to see in a patient who is alkalotic?
A premature infant is diagnosed with Bronchopulmonary Dysplasia (BPD). The characteristics of their alveoli will include:
A premature infant is diagnosed with Bronchopulmonary Dysplasia (BPD). The characteristics of their alveoli will include:
According to the diagnostic criteria, what signifies moderate Bronchopulmonary Dysplasia (BPD) in an infant born before 32 weeks gestational age?
According to the diagnostic criteria, what signifies moderate Bronchopulmonary Dysplasia (BPD) in an infant born before 32 weeks gestational age?
What is the most common genitourinary manifestation of Cystic Fibrosis (CF) in males?
What is the most common genitourinary manifestation of Cystic Fibrosis (CF) in males?
A 1-month-old patient presents with meconium ileus. Which condition is most likely suspected?
A 1-month-old patient presents with meconium ileus. Which condition is most likely suspected?
A patient with Cystic Fibrosis (CF) experiences increased dysnpea and digital clubbing. What pulmonary manifestation is most likely occurring?
A patient with Cystic Fibrosis (CF) experiences increased dysnpea and digital clubbing. What pulmonary manifestation is most likely occurring?
Which dietary intervention is the most appropriate for individuals with Cystic Fibrosis (CF) to manage pancreatic insufficiency and malabsorption?
Which dietary intervention is the most appropriate for individuals with Cystic Fibrosis (CF) to manage pancreatic insufficiency and malabsorption?
What is thought to cause Idiopathic Pulmonary Fibrosis (IPF)?
What is thought to cause Idiopathic Pulmonary Fibrosis (IPF)?
Which of the following represents a typical finding upon physical examination of a patient with Idiopathic Pulmonary Fibrosis (IPF)?
Which of the following represents a typical finding upon physical examination of a patient with Idiopathic Pulmonary Fibrosis (IPF)?
Which diagnostic method yields the most definitive information for confirming Idiopathic Pulmonary Fibrosis (IPF)?
Which diagnostic method yields the most definitive information for confirming Idiopathic Pulmonary Fibrosis (IPF)?
What is a significant physiological consequence of chronic bronchitis in the pathogenesis of COPD?
What is a significant physiological consequence of chronic bronchitis in the pathogenesis of COPD?
A patient who uses pursed-lip breathing and has a "barrel" chest likely has which of the following?
A patient who uses pursed-lip breathing and has a "barrel" chest likely has which of the following?
What best describes the mechanism of pulmonary hypertension development related to chronic lung disease or hypoxemia?
What best describes the mechanism of pulmonary hypertension development related to chronic lung disease or hypoxemia?
A patient with pulmonary hypertension is likely to experience what?
A patient with pulmonary hypertension is likely to experience what?
When assessing for pulmonary hypertension, what would the results of right heart catheterization reveal?
When assessing for pulmonary hypertension, what would the results of right heart catheterization reveal?
What is a key pathological process in the development of cor pulmonale secondary to pulmonary hypertension?
What is a key pathological process in the development of cor pulmonale secondary to pulmonary hypertension?
What is most likely to be found during assessment of a patient demonstrating signs of increased right ventricular pressure related to heart failure?
What is most likely to be found during assessment of a patient demonstrating signs of increased right ventricular pressure related to heart failure?
What is the significance of a declining oxygen saturation in a patient with dyspnea?
What is the significance of a declining oxygen saturation in a patient with dyspnea?
Which condition is considered a qualification for potential lung transplant?
Which condition is considered a qualification for potential lung transplant?
What would disqualify an individual from being a candidate for a lung transplant?
What would disqualify an individual from being a candidate for a lung transplant?
After a lung transplant, what does identification of infection signs suggest?
After a lung transplant, what does identification of infection signs suggest?
What is the clinical significance of monitoring spirometry findings in a patient post-lung transplant?
What is the clinical significance of monitoring spirometry findings in a patient post-lung transplant?
Following a lung transplant, which of the following etiological agents are the suspected cause if the patient begins to have a productive cough, dyspnea at rest, and airway obstruction?
Following a lung transplant, which of the following etiological agents are the suspected cause if the patient begins to have a productive cough, dyspnea at rest, and airway obstruction?
Flashcards
What is an alveolus?
What is an alveolus?
A sac that fills with air, enabling gas exchange in the lungs.
What is the airway?
What is the airway?
Trachea, bronchi, and bronchioles that carry air to the alveoli.
What are alveolar membranes?
What are alveolar membranes?
They allow oxygen to diffuse into the blood and carbon dioxide to exit.
What are pulmonary blood vessels?
What are pulmonary blood vessels?
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What is restrictive lung disease?
What is restrictive lung disease?
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What is obstructive lung disease?
What is obstructive lung disease?
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What happens during Obstruction?
What happens during Obstruction?
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What happens during Restriction?
What happens during Restriction?
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What is residual volume?
What is residual volume?
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What is tidal volume?
What is tidal volume?
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What is V/Q?
What is V/Q?
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What is a normal V/Q ratio?
What is a normal V/Q ratio?
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What are normal ABG ranges?
What are normal ABG ranges?
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What is Bronchopulmonary Dysplasia (BPD)?
What is Bronchopulmonary Dysplasia (BPD)?
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What increases the risk of BPD?
What increases the risk of BPD?
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What are manifestations of BPD?
What are manifestations of BPD?
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What is Cystic Fibrosis (CF)?
What is Cystic Fibrosis (CF)?
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What is the major feature of CF?
What is the major feature of CF?
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What happens during CF GI issues?
What happens during CF GI issues?
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What type is caused by CF?
What type is caused by CF?
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What is Idiopathic Pulmonary Fibrosis (IPF)?
What is Idiopathic Pulmonary Fibrosis (IPF)?
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What are risk factors for IPF?
What are risk factors for IPF?
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What are the Signs and symptoms IPF?
What are the Signs and symptoms IPF?
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What are the cause of COPD?
What are the cause of COPD?
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What are features of chronic bronchitis?
What are features of chronic bronchitis?
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What defines Pulmonary Hypertension?
What defines Pulmonary Hypertension?
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What happens in Pulmonary Arterial Hypertension (PAH)?
What happens in Pulmonary Arterial Hypertension (PAH)?
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What happens in Pulmonary Venous Hypertension (PVH)?
What happens in Pulmonary Venous Hypertension (PVH)?
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What are early symptoms of pulmonary hypertension?
What are early symptoms of pulmonary hypertension?
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What are later symptoms of pulmonary hypertension?
What are later symptoms of pulmonary hypertension?
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What is Cor Pulmonale?
What is Cor Pulmonale?
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What are Symptoms of Cor Pu?
What are Symptoms of Cor Pu?
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What is lung transplant?
What is lung transplant?
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What are Qualifications for Lung Transplantation?
What are Qualifications for Lung Transplantation?
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What are Contraindications for Lung Transplantation?
What are Contraindications for Lung Transplantation?
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What are types of lung transplants??
What are types of lung transplants??
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What are things to look for in acute lung rejection?
What are things to look for in acute lung rejection?
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What are things to look for in chronic lung rejection?
What are things to look for in chronic lung rejection?
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If a patient has right side heart failure, what are the related signs/symptoms to look for?
If a patient has right side heart failure, what are the related signs/symptoms to look for?
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Study Notes
Respiratory System Overview
- Potential areas for pathologies include the structures and function of the respiratory system.
- Dysfunction in the respiratory system leads to various issues.
- Common tests assess both pulmonary structure and function.
- Obstructive and restrictive lung diseases differ, impacting airflow.
Bronchopulmonary Dysplasia (BPD)
- BPD may arise from premature or low birth weight with respiratory issues.
- Risk factors for BPD include prematurity, postnatal sepsis, and pulmonary hypoplasia.
- Clinical manifestations of BPD include hypoxemia and increased work of breathing.
- Diagnosis requires meeting specific gestational age criteria and treatment with supplemental oxygen.
- Babies with BPD often have fewer and larger alveoli that are surrounded by thicker walls.
- Diagnosing BPD occurs when babies struggle to wean from mechanical ventilation.
Cystic Fibrosis (CF)
- CF results from an autosomal recessive gene, common among Caucasian populations, with a life expectancy of around 40 years.
- It begins with a mutation that regulates salt transport in and out of cells producing abnormally thick secretions.
- CFTR proteins malfunction or are insufficiently produced, causing a chloride buildup
- CFTR gene mutations generate CFTR protein dysfunctions and affect the respiratory tract and pancreas.
- Canada-wide newborn screenings include immunoreactive trypsinogen (IRT) protein level checks.
- Cilia malfunction from thick mucus secretions, leading to poor bacterial clearance.
- Diagnostic evaluation includes sweat chloride tests and genetic testing.
CF can lead to pneumothorax
- Chronic inflammation causes a dilation and damage to the bronchi.
- Cavitations or cysts, areas of bronchiolar consolidation, fibrosis and air-trapping develop in lung tissue.
- Air-trapping increases pressure in alveolar tissue, compromising respiratory adequacy.
- Inflammation weakens airway walls, leading to blebs and bullae in visceral pleura that leak into the pleural space.
- Pulmonary Manifestations include recurrent wheezing and thick secretion.
- GI issues include pancreatic insufficiency, biliary obstruction, and intestinal obstruction.
- Manifestations include meconium ileus, large bulky stools, malnutrition.
- Genitourinary effects include male infertility (blocked vas deferens) and female infertility (thick cervical secretions).
- A high calorie, high protein diet is required to cope with the malnutrition.
Idiopathic Pulmonary Fibrosis (IPF)
- IPF is a chronic, progressive fibrosing disorder limited to the lungs.
- Median survival is 2-4 years after diagnosis, with typical onset at 50-70 years.
- Common risk factors include smoking, viral infections, and environmental pollutants.
- Clinical presentation includes exertional dyspnea, non-productive cough, and crackles.
- The prognosis at diagnosis is approximately 3 years.
Chronic Obstructive Pulmonary Disease (COPD)
- COPD causes include pollution, smoking, asthma, chemical exposure, and AAT deficiency.
- Pathogenesis involves inflammation of the airway epithelium and protease activity.
Pulmonary Hypertension
- Pulmonary hypertension is indicated by elevated pulmonary artery pressures (PAP) above 25 mmHg.
- Pulmonary arterial hypertension (PAH) from pulmonary arteriole abnormalities.
- Pulmonary venous hypertension (PVH) arises from increased left atrial pressure.
- PAH is caused by idiopathic factors, left ventricular diseases/failure, chronic lung disease, and COPD.
- Late symptoms also include jugular vein distention and tricuspid regurgitation murmur.
- Diagnosis includes measuring right atrial and ventricular pressures via pulmonary artery catheterization.
Right Heart Failure (Cor Pulmonale)
- Right heart failure can result from pulmonary hypertension increasing pressure on the RV.
- Initial state includes symptoms of dyspnea or fatigue due to underlying lung disorder that occur with exercise when cardiac output falls.
Lung Transplants
- Lung transplants have become a treatment option for patients with end-stage conditions like emphysema.
- The first human lung transplant occurred in 1963, and emphysema in 1986 in Ontario.
- In 2021, 352 lung transplants occurred in Canada.
- Canada has four lung transplant centers: Vancouver, Edmonton, Toronto, Montreal.
- Conditions include advanced COPD, CF, idiopathic pulmonary fibrosis, and hypertension.
- Qualifications include untreatable end-stage lung disease and acceptable nutritional status for transplant.
- Types of transplants include lobe, single-lung, double-lung, and heart-lung transplants.
- Contraindications include chronic illness, infections, obesity, chest wall deformity, and substance use.
- Post-transplant survival averages 4.6 years for single-lung and 6.6 years for double-lung transplants.
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