Lecture 13: Respiratory System: Organs & Histology

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Questions and Answers

Which statement best describes the functional relationship between angiotensin and ADH activity in the context of respiratory function?

  • There is no direct functional relationship between angiotensin and ADH activity within the respiratory system.
  • Angiotensin directly inhibits ADH release, leading to decreased water retention and increased blood pressure.
  • Angiotensin II, formed by the respiratory system, stimulates ADH secretion, promoting water reabsorption and contributing to blood pressure regulation. (correct)
  • The respiratory system facilitates the conversion of ADH to angiotensin, thereby directly regulating blood pressure.

A patient presents with a condition affecting platelet production. If more than 50% of platelets are produced in the lungs, what specific cellular component within the lungs would be most directly involved in this process?

  • Pneumocytes
  • Alveolar macrophages
  • Megakaryocytes (correct)
  • Goblet cells

How does the mucociliary escalator function to protect the respiratory system, and what cellular components are essential for its operation?

  • It utilizes the pressure gradient created by breathing to passively filter out particulate matter in the larger airways.
  • It relies on the diffusion of antimicrobial peptides across the epithelial lining to neutralize pathogens within the alveoli.
  • It uses alveolar macrophages to engulf and digest foreign particles, propelled by smooth muscle contractions.
  • It traps debris in a mucus layer secreted by goblet cells, which is then moved by ciliated epithelium towards the pharynx to be swallowed or expelled. (correct)

What would be the most likely consequence of damage to the Type II pneumocytes within the alveoli?

<p>Increased alveolar surface tension, leading to alveolar collapse and impaired gas exchange (D)</p> Signup and view all the answers

How does the structural arrangement of cartilage in the trachea contribute to its specific function within the respiratory system?

<p>The C-shaped cartilage rings provide rigid support to prevent collapse during inhalation while allowing the esophagus to expand during swallowing. (C)</p> Signup and view all the answers

Within the nasal cavity, the meatuses play a crucial role in conditioning inhaled air. How do they achieve this function?

<p>By increasing the surface area of the nasal mucosa to enhance warming, humidification, and cleansing of the air (D)</p> Signup and view all the answers

How does the histological structure of the respiratory epithelium in the nasal cavity differ from that of the olfactory epithelium, and how do these differences relate to their respective functions?

<p>The respiratory epithelium is characterized by motile cilia and goblet cells for mucociliary clearance, while the olfactory epithelium has non-motile cilia to bind odorants. (B)</p> Signup and view all the answers

Which of the following statements accurately describes the function of the Eustachian tubes, and how does the nasopharynx contribute to maintaining this function?

<p>Eustachian tubes equalize pressure between the middle ear and the atmosphere, and the nasopharynx connects them to the nasal cavity. (C)</p> Signup and view all the answers

What is the primary mechanism by which the epiglottis prevents aspiration during swallowing, and what anatomical structures contribute to this process?

<p>The epiglottis folds downward to cover the larynx, while extrinsic muscles elevate the larynx to facilitate the passage of food into the esophagus. (D)</p> Signup and view all the answers

During the act of swallowing, several coordinated actions prevent food from entering the respiratory tract. What role do the vestibular folds play in this process?

<p>They close the larynx, providing a secondary defense mechanism to prevent aspiration if the epiglottis fails. (D)</p> Signup and view all the answers

How does the structural composition of the bronchioles, specifically the absence of supporting cartilage, influence their function during respiration, especially under conditions of increased respiratory demand?

<p>The absence of cartilage enables the bronchioles to constrict more effectively, redirecting airflow to the most efficiently perfused alveoli. (B)</p> Signup and view all the answers

The bronchial tree undergoes several transitions in its histological structure as it branches from the trachea to the alveoli. How does the epithelium change, and how does this modification support the function of each region?

<p>It changes from pseudostratified columnar with goblet cells and cilia in the trachea to simple squamous in the alveoli for efficient gas exchange. (C)</p> Signup and view all the answers

What is the functional significance of the elastic connective tissue present within the walls of the bronchial tree, and how does it contribute to respiratory mechanics?

<p>It enables the airways to recoil during exhalation, assisting in expelling air from the lungs and reducing the work of breathing. (C)</p> Signup and view all the answers

Within the alveoli, a delicate balance is maintained to ensure efficient gas exchange. How do Type I and Type II pneumocytes coordinate their functions to optimize this process?

<p>Type I pneumocytes are responsible for gas exchange, while Type II pneumocytes repair damaged epithelium and secrete surfactant to reduce surface tension. (B)</p> Signup and view all the answers

How does the structure of the respiratory membrane facilitate efficient gas exchange between the alveoli and the pulmonary capillaries?

<p>It is a thin barrier consisting of the alveolar epithelium, the capillary endothelium, and their fused basement membranes, minimizing the diffusion distance for gases. (C)</p> Signup and view all the answers

Given the structural arrangement of the lungs, where the right lung has three lobes and the left lung has two, how does this asymmetry affect lung function, and what anatomical structures contribute to this difference?

<p>The asymmetry accommodates the position of mediastinal organs such as the heart, impacting the overall volume and shape of the left lung. (D)</p> Signup and view all the answers

The inspiratory pathway involves a sequence of structures through which air travels into the lungs. How does the transition from the conducting zone to the respiratory zone affect the primary function of the respiratory system?

<p>It shifts from primarily air transport to gas exchange as the structure transitions from bronchioles to alveolar ducts and alveoli. (D)</p> Signup and view all the answers

A patient has a genetic condition that impairs the function of non-motile cilia in their olfactory epithelium. What specific symptom would you expect this patient to exhibit?

<p>Inability to perceive odors due to the cilia's role in binding odorants (C)</p> Signup and view all the answers

A researcher is studying the effects of air pollution on the respiratory system and focuses on the role of alveolar macrophages. What primary function of these cells makes them crucial in this context?

<p>Phagocytizing particulate matter and pathogens in the alveoli, thereby preventing infection and tissue damage (D)</p> Signup and view all the answers

A patient is diagnosed with a condition that reduces the production of serous fluid by the glands in their olfactory epithelium. What specific function of the olfactory system would be most directly affected by this deficiency?

<p>The efficiency of removing odorants from the olfactory receptors to allow for new odor detection (B)</p> Signup and view all the answers

Following a traumatic injury to the neck, a patient experiences difficulty speaking and has a hoarse voice. Which specific structure might have been damaged to cause these symptoms?

<p>Larynx (A)</p> Signup and view all the answers

In infants, the anatomical relationship between the epiglottis and the soft palate differs from that in adults. How does this difference affect their ability to breathe and swallow simultaneously?

<p>It allows infants to coordinate breathing and swallowing more easily as the epiglottis touches the soft palate, creating a continuous airway. (C)</p> Signup and view all the answers

A patient presents with a rare condition characterized by the absence of goblet cells in the tracheal epithelium. What immediate physiological consequence would you expect to observe in this patient?

<p>Increased risk of respiratory infection due to impaired mucociliary clearance (A)</p> Signup and view all the answers

Which of the following accurately describes the order in which air passes through the structures of the respiratory system during inspiration?

<p>Pharynx, larynx, trachea, primary bronchus, bronchioles, alveolar duct, alveoli (B)</p> Signup and view all the answers

Which statement correctly links a specific respiratory structure to its primary function in the respiratory system?

<p>Alveoli – facilitate gas exchange between air and blood due to their large surface area and thin walls (D)</p> Signup and view all the answers

How do the actions of the extrinsic muscles contribute to the process of swallowing in the larynx?

<p>They elevate the larynx, facilitating the epiglottis's role in preventing food from entering the airway. (C)</p> Signup and view all the answers

How does the arrangement of hyaline cartilage in the trachea support its function?

<p>It prevents the trachea from collapsing during inhalation while allowing flexibility for swallowing. (C)</p> Signup and view all the answers

How does the transition from bronchioles to terminal bronchioles affect the structural support and function in the respiratory system?

<p>Elastic connective tissue increases, aiding recoil during exhalation. (C)</p> Signup and view all the answers

What aspect of Type II pneumocytes is crucial for maintaining alveolar structure and function?

<p>Their secretion of surfactant, which reduces surface tension. (B)</p> Signup and view all the answers

How does the arrangement of the lungs, with the right lung having three lobes and the left lung having two, functionally impact respiration and space within the thoracic cavity?

<p>It provides additional space for the heart, influencing lung capacity and thoracic symmetry. (C)</p> Signup and view all the answers

How does the presence of non-motile cilia on olfactory epithelium directly contribute to the sense of smell?

<p>By binding and concentrating odorants, facilitating their detection. (D)</p> Signup and view all the answers

What role do alveolar macrophages play in maintaining a sterile environment within the alveoli for gas exchange?

<p>They engulf and digest inhaled particles and pathogens. (C)</p> Signup and view all the answers

How does the serous fluid secreted by glands in the olfactory epithelium uniquely support olfactory function?

<p>It dissolves odor molecules, facilitating their interaction with olfactory receptors. (C)</p> Signup and view all the answers

What specific mechanism prevents food from entering the respiratory tract when the epiglottis moves to cover the larynx during swallowing?

<p>The vestibular folds close, providing a physical barrier. (C)</p> Signup and view all the answers

What is the functional significance of the anatomical difference in the relationship between the epiglottis and soft palate in infants compared to adults?

<p>It enables infants to breathe and swallow simultaneously. (A)</p> Signup and view all the answers

How does the mucociliary escalator function, and what immediate effect would be observed if goblet cells were absent in the tracheal epithelium?

<p>It propels mucus and debris upwards; absence would lead to a dry, unprotected airway. (D)</p> Signup and view all the answers

How does the arrangement of the nasal meatuses within the nasal cavity specifically condition inhaled air for its subsequent passage into the lower respiratory tract?

<p>By increasing the surface area for air to be warmed, humidified, and cleansed. (B)</p> Signup and view all the answers

How does the architecture of the respiratory membrane facilitate efficient gas exchange at the alveolar level?

<p>It is extremely thin, allowing for minimal diffusion distance between air and blood. (B)</p> Signup and view all the answers

What structural feature of the trachea primarily facilitates expansion of the esophagus during swallowing?

<p>The posterior opening in the tracheal cartilage. (D)</p> Signup and view all the answers

What change in epithelial structure occurs as the respiratory system transitions from the trachea to the terminal bronchioles, and how does this facilitate respiratory function?

<p>The pseudostratified columnar epithelium gradually transitions to cuboidal epithelium, then to a simple squamous epithelium in the alveoli, reducing thickness and increasing surface area for gas exchange. (C)</p> Signup and view all the answers

What is the primary function of the Eustachian tubes, and how does the nasopharynx contribute to maintaining this function?

<p>Equalizing pressure in the middle ear. (D)</p> Signup and view all the answers

If a patient has damaged Type II pneumocytes, how would this directly affect the function of the alveoli?

<p>The alveoli would be more prone to collapse due to increased surface tension. (C)</p> Signup and view all the answers

How does the presence of elastic fibers in the walls of the bronchial tree contribute to lung function?

<p>They facilitate the recoil of the lungs during exhalation. (B)</p> Signup and view all the answers

What role does the larynx play in phonation (sound production), and how do the vocal cords contribute to this process?

<p>It houses the vocal cords, which vibrate to produce sound as air passes over them. (C)</p> Signup and view all the answers

During inspiration, air moves through a series of respiratory structures. What distinguishes the conducting zone from the respiratory zone regarding function?

<p>The conducting zone warms and filters air, while the respiratory zone facilitates gas exchange. (A)</p> Signup and view all the answers

A patient presents with hoarseness and difficulty speaking after a neck injury. Which laryngeal structure is most likely affected?

<p>The vocal cords are most likely damaged. (D)</p> Signup and view all the answers

How would a reduction in serous fluid production by the glands in the olfactory epithelium directly affect olfaction?

<p>It would reduce the ability to dissolve odor molecules, hindering their interaction with receptors. (A)</p> Signup and view all the answers

What is the specific role of the mucociliary escalator in respiratory defense, and how does it accomplish this function?

<p>It propels mucus containing trapped particles out of the respiratory tract via coordinated ciliary action. (B)</p> Signup and view all the answers

How does the coordinated action of Type I and Type II pneumocytes optimize gas exchange within the alveoli?

<p>Type I pneumocytes facilitate gas diffusion with their thin structure, while Type II pneumocytes secrete surfactant to reduce surface tension. (A)</p> Signup and view all the answers

Flashcards

Gas exchange in respiration

The exchange of O2 and CO2 between blood and air within the lungs.

Communication (Respiration)

Speech and other vocalizations produced through the respiratory system.

Olfaction

The sense of smell, enabled by specialized receptors in the nasal cavity.

Acid-base balance (Respiration)

Influences blood pH by eliminating carbon dioxide.

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Blood pressure regulation (Respiration)

Regulation involving angiotensin and its effect on ADH activity.

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Nose Functions

The nose warms, cleanses, and humidifies inhaled air.

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Olfactory Epithelium

Type of epithelium in the nose with non-motile cilia that bind olfactants for smell.

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Respiratory Epithelium

Type of epithelium in the nose with motile cilia and goblet cells that produce mucus.

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Pharynx

Muscular funnel that connects the nasal system to the larynx.

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Nasopharynx

A region of the pharynx posterior to nasal apertures, above the soft palate.

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Oropharynx

Region of the pharynx back of the oral cavity located from the soft palate to the epiglottis

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Laryngopharynx

Region of the pharynx located from the tip of the epiglottis, behind larynx.

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Larynx

Cartilaginous chamber involved in sound production and prevention of choking.

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Epiglottis

Spoon-shaped supportive plate in the epiglottis that prevents food from entering the trachea.

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Thyroid Cartilage

Shield-shaped cartilage of the larynx; the largest cartilage.

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Cricoid Cartilage

Ring-like cartilage that connects the larynx to the trachea.

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Trachea

"Windpipe" connecting the larynx to the bronchi.

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Tracheal Cartilage Rings

C-shaped cartilage rings that support the trachea preventing collapse during inhalation.

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Trachealis Muscle

Muscle that adjusts airflow by contracting or relaxing.

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Lung Lobes

Each lung has different number of lobes. Right has three, left has two

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Bronchial Tree

Branching system of air tubes in each lung.

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Primary Bronchi

Give rise to about 65,000 terminal bronchioles.

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Terminal Bronchioles

Smallest branches of the bronchioles; lack supporting cartilage.

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Respiratory Bronchioles

Lead to alveolar ducts.

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Alveoli

Clustered together in alveolar sacs, microscopic air pouches.

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Blood and Lymph Flow (Respiration)

Pressure gradients from the thorax aid in blood and lymph flow.

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Platelet production

Aid Platelet production - more than 50% of platelets by megakaryocytes in lungs (not in bone marrow)

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Blood Filtration (Respiration)

Lungs filter out small clots from the bloodstream.

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Expulsion of abdominal contents

Breath-holding assists in urination, defecation, and childbirth.

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Conducting Zone

Passages exclusively for airflow; from nostrils to major bronchioles.

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Respiratory Zone

Regions where gas exchange occurs; includes alveoli.

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Upper Respiratory System

Organs located in the head and neck, including the nose and larynx.

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Lower Respiratory System

Extends from the trachea through the lungs.

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Nostrils (Choanae)

Posterior nasal apertures.

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Nasal Cavities

R & L nasal cavities

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Nose Vestibule

The vestibule contains guard hairs.

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Nasal Meatuses

Traps debris with mucus in the nose.

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Pseudostratified Columnar Epithelium

A mucous membrane that lines the trachea, nasal cavity, and larger bronchi

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Posterior Tracheal Opening

Opening in trachea allowing expansion of esophagus during swallowing.

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Mucociliary Escalator

Debris removal system in the trachea

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Alveolar Ducts

Lead from the respiratory bronchioles

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Type I alveolar cells(/pneumocytes)

Simple squamous cells; thin for gas exchange.

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Type II alveolar cells(/pneumocytes)

Cuboidal cells; secrete surfactant and repair epithelium.

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Dust Cells

Clear debris in alveoli.

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Alveolar Ducts

First part of the respiratory zone

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Respiratory Airflow Pathway

Structures nasal cavity/mouth, pharynx, larynx, trachea, primary bronchus

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Study Notes

  • Chapter 22 Summary: Review, Organs, & Histology of the Respiratory System

Objectives

  • Name and describe organs of the respiratory system.
  • Describe the microscopic anatomy of respiratory organs and structures.
  • Connect microscopic anatomy to function.
  • Describe the pathway of inspiration and expiration.

Functions of the Respiratory System

  • Allows gas exchange of oxygen and carbon dioxide between blood and air.
  • Enables communication through speech and other vocalizations.
  • Facilitates olfaction, the sense of smell.
  • Influences the pH of body fluids by eliminating carbon dioxide, thus maintaining acid-base balance.
  • Regulates blood pressure via the angiotensin pathway and ADH activity.
  • Blood and lymph flow is aided by pressure gradients from the thorax.
  • Platelets are produced by megakaryocytes in the lungs, accounting for more than 50% of total platelet production, surpassing bone marrow production.
  • Filters small clots from the blood.
  • Breath-holding assists in urination, defecation, and childbirth, aiding in the expulsion of abdominal contents.

Divisions of the Respiratory System

  • The conducting zone includes passages for airflow only.
  • The conducting zone contains the nostrils and major bronchioles.
  • The respiratory zone is where gas exchange occurs.
  • The respiratory zone contains the alveoli.
  • The upper respiratory system includes organs in the head and neck.
  • The upper respiratory system consists of the nose and larynx.
  • The lower respiratory system extends from the trachea through the lungs.

Nose

  • Nostrils lead to posterior nasal apertures called choanae.
  • There are right and left nasal cavities.
  • The vestibule contains guard hairs.
  • Meatuses are covered by mucus, which collects dust.
  • Responsible for cleansing, humidifying, and warming air.
  • Detects odors.
  • The nasal cavity is divided by the septum.
  • The palate separates the nasal and oral cavities.

Nose Histology

  • The olfactory epithelium is pseudostratified.
  • Cilia is non-motile and binds olfactants.
  • Involved in the sense of smell.
  • Glands secrete serous fluid to aid in olfaction.
  • Respiratory epithelium is pseudostratified.
  • Cilia is motile.
  • Goblet cells and mucous glands produce mucus.

Pharynx

  • The pharynx functions as a muscular funnel.
  • It connects the nasal system to the larynx.
  • The nasopharynx is positioned posterior to the nasal apertures and above the soft palate.
  • Eustachian tubes balance middle ear pressure.
  • Traps large particles in mucus and is pseudostratified columnar.
  • The Oropharynx is located behind oral cavity.
  • The Oropharynx is made of stratified squamous tissue.
  • The laryngopharynx is located behind the larynx.
  • The Laryngopharynx is stratified squamous.

Larynx

  • A cartilaginous chamber used for sound production and preventing choking.
  • The epiglottic is spoon-shaped and provides support in the epiglottis.
  • The thyroid cartilage is shield-shaped and the largest.
  • The cricoid cartilage is ring-like and connects the larynx to the trachea.
  • Keeps food and drink out of the airway.
  • The epiglottis protects the airway.
  • Infants have an epiglottis that touches the soft palate
  • Extrinsic muscles moves the larynx upwards during swallowing.
  • The tongue pushes the epiglottis downward during swallowing.
  • Vestibular folds close the larynx.
  • Sound production via vocal cords
  • Intrinsic muscles are involved in sound production

Trachea

  • Known as the "windpipe," connecting the larynx to the bronchi.
  • Contains 16–20 C-shaped cartilage rings made of hyaline cartilage.
  • Prevents collapse during inhalation.
  • The posterior opening allows the esophagus to expand.
  • The trachealis muscle adjusts airflow.
  • Has a pseudostratified columnar lining with goblet cells, cilia, and stem cells.
  • The mucociliary escalator removes debris.

Histology - Trachea

  • Ciliated epithelium cells and goblet cells

Lungs

  • The right lung has three lobes.
  • The left lung has two lobes.
  • Asymmetry is due to other organs.
  • The heart, diaphragm, and liver affect lung placement.

Bronchial Tree

  • A branching system of air tubes in each lung.
  • Primary bronchi leads to 65,000 terminal bronchioles
  • Pseudostratified columnar epithelium.
  • Thinner with distance from trachea.
  • Elastic connective tissue enables recoiling.
  • Bronchioles lead to terminal bronchioles
  • Lacks supporting cartilage.
  • Terminal bronchioles lead to respiratory bronchioles
  • Respiratory bronchioles lead to alveolar ducts
  • Alveoli are clustered together in "alveolar sacs."

Alveoli

  • Microscopic air pouches, ~40 million/lung → 70 m² of surface
  • Type I (squamous) cells have a simple squamous shape, are thin, and facilitates gas exchange.
  • Type II (great) cells are cuboidal and thicker.
  • Type II (great) cells repair damaged epithelium, secrete surfactant, prevent bronchioles from collapsing, and reduce friction.
  • Dust cells (alveolar macrophages)

Respiratory Membrane

  • A thin barrier between the alveolar air and blood

Inspiratory Pathway

  • Nasal cavity or mouth
  • Pharynx
  • Larynx
  • Trachea
  • Primary bronchus
  • Bronchioles
  • Terminal bronchiole
  • Respiratory bronchiole
  • Alveolar duct
  • Alveoli

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