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Questions and Answers
Which muscle is NOT involved in forced inhalation?
Which muscle is NOT involved in forced inhalation?
Quiet expiration is a passive process because:
Quiet expiration is a passive process because:
Which condition is NOT directly associated with Type 1 Respiratory Failure?
Which condition is NOT directly associated with Type 1 Respiratory Failure?
During external respiration, the primary exchange of gases occurs between:
During external respiration, the primary exchange of gases occurs between:
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What is the normal partial pressure of oxygen (PaO2) in the alveolar space?
What is the normal partial pressure of oxygen (PaO2) in the alveolar space?
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What is the primary function of the accessory muscles of inspiration?
What is the primary function of the accessory muscles of inspiration?
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Which scenario reflects a ventilation-perfusion (V/Q) mismatch?
Which scenario reflects a ventilation-perfusion (V/Q) mismatch?
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Which of the following is NOT a potential cause of Type 1 Respiratory Failure?
Which of the following is NOT a potential cause of Type 1 Respiratory Failure?
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What is the primary function of the diaphragm in breathing?
What is the primary function of the diaphragm in breathing?
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What is the term for the exchange of gases between blood and cells?
What is the term for the exchange of gases between blood and cells?
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Which of the following is NOT a function of the paranasal sinuses?
Which of the following is NOT a function of the paranasal sinuses?
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What is the primary function of the epiglottis during respiration?
What is the primary function of the epiglottis during respiration?
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Which of the following structures is responsible for the production of surfactant?
Which of the following structures is responsible for the production of surfactant?
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What is the function of the cilia in the bronchi and bronchioles?
What is the function of the cilia in the bronchi and bronchioles?
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Which of the following statements is TRUE regarding the differences between the right and left lungs?
Which of the following statements is TRUE regarding the differences between the right and left lungs?
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Which of the following describes the correct order of structures through which air travels from the nasal cavity to the alveoli?
Which of the following describes the correct order of structures through which air travels from the nasal cavity to the alveoli?
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What is the role of the visceral pleura in the respiratory system?
What is the role of the visceral pleura in the respiratory system?
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What is the main function of the alveolar macrophages?
What is the main function of the alveolar macrophages?
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How would you explain the process of gas exchange in the alveoli?
How would you explain the process of gas exchange in the alveoli?
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Which of the following conditions would most likely affect the respiratory membrane and gas exchange?
Which of the following conditions would most likely affect the respiratory membrane and gas exchange?
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What are the consequences of poor compliance of the alveoli?
What are the consequences of poor compliance of the alveoli?
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Which of the following is NOT a component of the conducting system?
Which of the following is NOT a component of the conducting system?
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What is the primary function of the pulmonary vessels?
What is the primary function of the pulmonary vessels?
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What is the role of the bronchial vessels?
What is the role of the bronchial vessels?
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Which of the following is NOT a component of the respiratory zone?
Which of the following is NOT a component of the respiratory zone?
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What is the main cause of COPD deaths?
What is the main cause of COPD deaths?
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What is the main enzyme responsible for proteolysis in the lungs?
What is the main enzyme responsible for proteolysis in the lungs?
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Which of these symptoms is NOT associated with emphysema?
Which of these symptoms is NOT associated with emphysema?
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What is the main pathological change in the lungs of an emphysema patient?
What is the main pathological change in the lungs of an emphysema patient?
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Which of these is NOT a common complication of COPD?
Which of these is NOT a common complication of COPD?
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What is the correct definition of status asthmaticus?
What is the correct definition of status asthmaticus?
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What is the term used for the condition where the airway collapses due to loss of lung recoil?
What is the term used for the condition where the airway collapses due to loss of lung recoil?
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Which of these is NOT a risk factor for COPD?
Which of these is NOT a risk factor for COPD?
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What is the main reason for the increased mortality related to COPD?
What is the main reason for the increased mortality related to COPD?
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What is the term used for the increased sensitivity to bronchoprovocation testing in COPD patients?
What is the term used for the increased sensitivity to bronchoprovocation testing in COPD patients?
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What is the main difference between 'pink puffers' and 'blue bloaters' in COPD?
What is the main difference between 'pink puffers' and 'blue bloaters' in COPD?
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Which of these is NOT a pathological change associated with chronic bronchitis?
Which of these is NOT a pathological change associated with chronic bronchitis?
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What is the main function of Alpha-1-antitrypsin?
What is the main function of Alpha-1-antitrypsin?
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Which of these is NOT a clinical presentation of COPD?
Which of these is NOT a clinical presentation of COPD?
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What is the main pathophysiological mechanism behind COPD?
What is the main pathophysiological mechanism behind COPD?
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Which of the following is a genetic polymorphism associated with an increased risk of COPD?
Which of the following is a genetic polymorphism associated with an increased risk of COPD?
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Which factor is NOT associated with the etiology of asthma during childhood?
Which factor is NOT associated with the etiology of asthma during childhood?
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What is a hallmark of asthma pathology?
What is a hallmark of asthma pathology?
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Which mediator is released by mast cells during the allergen-induced bronchoconstriction?
Which mediator is released by mast cells during the allergen-induced bronchoconstriction?
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What triggers the release of inflammatory cells in the late-phase reaction of bronchial inflammation?
What triggers the release of inflammatory cells in the late-phase reaction of bronchial inflammation?
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Which of the following factors is classified as not related to occupational exposures?
Which of the following factors is classified as not related to occupational exposures?
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How does airway remodeling in asthma progress?
How does airway remodeling in asthma progress?
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What role do Th2 cells play in asthma?
What role do Th2 cells play in asthma?
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Which environmental exposure is recognized as a factor contributing to asthma in adulthood?
Which environmental exposure is recognized as a factor contributing to asthma in adulthood?
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What is a mechanism through which bronchoconstriction occurs?
What is a mechanism through which bronchoconstriction occurs?
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Which of the following is considered an asthma trigger?
Which of the following is considered an asthma trigger?
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What is the primary function of the peak-flow meter?
What is the primary function of the peak-flow meter?
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Which of the following is NOT a lung volume measured by spirometry?
Which of the following is NOT a lung volume measured by spirometry?
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Which lung function index is most helpful in differentiating between obstructive and restrictive lung disease?
Which lung function index is most helpful in differentiating between obstructive and restrictive lung disease?
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Which of these is NOT a characteristic of asthma?
Which of these is NOT a characteristic of asthma?
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What is the primary reason why people who smoke have poor exercise tolerance?
What is the primary reason why people who smoke have poor exercise tolerance?
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Which of the following is NOT a maternal factor associated with asthma risk in children?
Which of the following is NOT a maternal factor associated with asthma risk in children?
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Which of the following is a primary component of the Hygiene Hypothesis?
Which of the following is a primary component of the Hygiene Hypothesis?
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Which of the following is a common allergen associated with asthma?
Which of the following is a common allergen associated with asthma?
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How does aging affect lung function?
How does aging affect lung function?
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What is the primary function of the diaphragm in respiration?
What is the primary function of the diaphragm in respiration?
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What is the primary effect of a bronchodilator on the airways?
What is the primary effect of a bronchodilator on the airways?
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What is the main difference between acute and chronic compensation in acid-base balance?
What is the main difference between acute and chronic compensation in acid-base balance?
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What is the role of the kidneys in metabolic compensation of acid-base balance?
What is the role of the kidneys in metabolic compensation of acid-base balance?
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Which of the following is a common symptom of asthma?
Which of the following is a common symptom of asthma?
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What does 'airway hyper-responsiveness' mean in the context of asthma?
What does 'airway hyper-responsiveness' mean in the context of asthma?
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Which of the following is a potential benefit of exposure to endotoxin in early childhood?
Which of the following is a potential benefit of exposure to endotoxin in early childhood?
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What is the role of cilia in the respiratory system?
What is the role of cilia in the respiratory system?
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Flashcards
Nose and nasal cavity
Nose and nasal cavity
Provides airway for respiration, moistens and filters air, contains olfactory receptors.
Paranasal sinuses
Paranasal sinuses
Air-containing cavities in the skull lined with mucous membrane, decreases skull weight and increases voice resonance.
Pharynx
Pharynx
Upper part of the throat that serves as an air and food passageway, divided into nasopharynx, oropharynx, and laryngopharynx.
Larynx
Larynx
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Trachea
Trachea
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Bronchi
Bronchi
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Lungs
Lungs
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Alveoli
Alveoli
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Type I cells
Type I cells
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Type II cells
Type II cells
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Lung compliance
Lung compliance
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Pulmonary vessels
Pulmonary vessels
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Conducting system
Conducting system
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Respiration
Respiration
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Pulmonary ventilation
Pulmonary ventilation
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Quiet inspiration
Quiet inspiration
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Forced inspiration
Forced inspiration
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Quiet expiration
Quiet expiration
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Forced expiration
Forced expiration
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External respiration
External respiration
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V/Q mismatch
V/Q mismatch
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Internal respiration
Internal respiration
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Low Omega-3
Low Omega-3
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Maternal Smoking
Maternal Smoking
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Pre-eclampsia
Pre-eclampsia
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Childhood Infections
Childhood Infections
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Tobacco Smoke Exposure
Tobacco Smoke Exposure
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Obesity and Asthma
Obesity and Asthma
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Asthma Triggers
Asthma Triggers
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Bronchial Hyper-reactivity
Bronchial Hyper-reactivity
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Airway Remodeling
Airway Remodeling
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Mast Cell Mediators
Mast Cell Mediators
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PaCO2
PaCO2
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PaO2
PaO2
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Metabolic Disorder
Metabolic Disorder
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Respiratory Disorder
Respiratory Disorder
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Respiratory Compensation
Respiratory Compensation
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Metabolic Compensation
Metabolic Compensation
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Spirometry
Spirometry
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Peak-flow Meter
Peak-flow Meter
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FEV1/FVC Ratio
FEV1/FVC Ratio
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Obstructive Lung Disease
Obstructive Lung Disease
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Restrictive Lung Disease
Restrictive Lung Disease
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Asthma
Asthma
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Genetic Predisposition
Genetic Predisposition
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Hygiene Hypothesis
Hygiene Hypothesis
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Atopic vs Non-Atopic
Atopic vs Non-Atopic
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COPD
COPD
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Status asthmaticus
Status asthmaticus
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Emphysema
Emphysema
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Chronic bronchitis
Chronic bronchitis
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Hypoxemia
Hypoxemia
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Mucociliary dysfunction
Mucociliary dysfunction
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Airflow limitation
Airflow limitation
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Cough and dyspnea
Cough and dyspnea
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Bronchodilator
Bronchodilator
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Inflammatory cell infiltration
Inflammatory cell infiltration
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Atopy
Atopy
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Hypercapnia
Hypercapnia
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Study Notes
Respiratory System Anatomy
- The upper respiratory tract includes the nose, nasal cavity, paranasal sinuses, pharynx, and larynx
- The nose and nasal cavity provide an airway for respiration, moisten and warm air, filter inhaled air, and contain olfactory receptors. They are also involved in speech.
- Paranasal sinuses are air-containing cavities in the skull lined with mucous membrane. Possible functions include decreasing skull weight, increasing voice resonance, buffering against facial trauma, insulating sensitive structures, humidifying and heating air, and supporting immunological defense.
- The pharynx is the upper part of the throat. It has three sections: nasopharynx (air passageway), oropharynx (food and air passageway), and laryngopharynx (connects throat to esophagus). It includes tonsils (nasopharyngeal and palatine/lingual).
- The larynx connects the laryngopharynx to the trachea and contains vocal folds. The thyroid gland sits on the outside of the larynx. The larynx's main function is protective, aiding in coughing and preventing food/fluid from entering the lungs.
- The lower respiratory tract includes the trachea, bronchi (and smaller bronchioles), lungs, and alveoli.
Respiratory System Physiology
- Respiration exchanges gases between the atmosphere, blood, and cells
- Components include pulmonary ventilation (breathing), external respiration (gas exchange between air and blood), and internal respiration (gas exchange between blood and cells)
Pulmonary Ventilation
- Inspiration (breathing in) occurs when alveolar pressure is less than atmospheric pressure. The diaphragm and external intercostal muscles contract, expanding the thoracic cavity. Forced inspiration utilizes accessory muscles.
- Expiration (breathing out) is a passive process. The diaphragm relaxes, and the thoracic cavity contracts causing air pressure to rise above atmospheric pressure, forcing air out. Forced expiration uses the abdominal muscles.
External Respiration
- External respiration is the exchange of gases between the air and blood in the alveoli and capillaries. Oxygen diffuses from the alveoli into the blood. Carbon dioxide diffuses from the blood into the alveoli.
- This process is driven by differences in partial pressures; normal partial pressure of oxygen (paO2) gradient: alveolar space= 100 mmHg, deoxygenated blood = 40 mmHg. Normal partial pressure of carbon dioxide (paCO2) gradient: alveolar space= 40 mmHg, deoxygenated blood = 45 mmHg.
Ventilation-Perfusion Matching
- Ventilation-perfusion matching is the balance of air flow into the alveoli and blood flow through the capillaries to facilitate external respiration.
- The ratio of ventilation (V) and perfusion (Q) must be balanced (approximately 0.8) for gas exchange. Disruptions (abnormal V/Q ratios) lead to hypoxemia (low blood oxygen).
Internal Respiration
- Internal respiration facilitates the exchange of oxygen and carbon dioxide between blood and the body’s cells. Oxygen diffuses from the blood into the cells. Carbon dioxide diffuses from the cells into the blood.
Type 1 and Type 2 Respiratory Failure
- Type 1 respiratory failure is characterized by the inability of the lungs to effectively exchange gases. It results in hypoxemia. Common causes include: lung disorders (asthma, COPD), pneumonia, pulmonary edema, fibrosis, and embolism.
- Type 2 respiratory failure involves the body's inability to effectively remove carbon dioxide. It results in hypercapnia. Potential causes include impaired CNS function, neuromuscular impairment, chronic bronchitis or COPD, and excessive inspiratory load. Both types can lead to complications if not treated promptly
Acid-Base Balance
- Arterial blood gases measure acid-base balance, aiding in determining the cause of respiratory issues. Blood pH is regulated by the lungs and kidneys.
- Compensation may occur by adjusting retention or excretion of CO2 (respiratory) and HCO3 (metabolic). The time course of compensation (acute vs. chronic) affects risk.
Lung Function Testing
- Spirometry measures lung function including lung volumes (Tidal Volume, Inspiratory Reserve Volume, Expiratory Reserve Volume, Residual Volume) and lung capacities (Total Lung Capacity, Functional Residual Capacity, Vital Capacity). Airflow measures, like FEV1/FVC ratio, differentiate between obstructive and restrictive lung disease.
- Peak flow meters aid in self-monitoring of lung function, particularly helpful for asthma patients. Spirometry to determine reversibility of airway obstruction is conducted by repeating the test 10-15 minutes after inhaling a bronchodilator. An increase in FEV1 indicates airway obstruction.
Effect of Fitness and Aging on the Respiratory System
- Proper respiratory function requires a strong cardiovascular system
- Exercise increases blood flow and oxygen consumption.
- Fitness improves lung capacity, gas diffusion, and strengthens respiratory muscles.
- Aging affects lung function through decreased lung compliance and weakened respiratory muscles. Smokers exhibit decreased exercise tolerance due to factors like nicotine-induced bronchoconstriction, lung fibrosis, excess mucus, cilia inhibition, and elastic fiber destruction
Asthma
- Asthma is a chronic inflammatory disorder marked by intermittent episodes of wheezing, coughing, and dyspnea, often worse at night or upon waking. Symptoms are associated with airway hyper-responsiveness.
- Possible diagnostic factors include: FEV1/FVC <0.7, significant reversibility post-bronchodilator challenge (>+12%), and sensitivity to broncho-provocation testing.
- Asthma exacerbations (status asthmaticus) can be life-threatening.
- Etiology and Risk factors includes: genetics, hygiene hypothesis, sex, maternal factors (pregnancy, smoking), perinatal factors, environmental factors (childhood, adulthood), and triggers.
COPD
- COPD (Chronic Obstructive Pulmonary Disease) is a chronic respiratory disease characterized by persistent symptoms, airflow limitation, chronic inflammation, and mucociliary dysfunction. Often a mix of emphysema and chronic bronchitis.
- COPD is associated with cigarette smoking, air pollutants, airway reactivity and genetic polymorphisms (Alpha-1 antitrypsin deficiency).
- Pathophysiology of emphysema includes imbalances in proteolytic and anti-proteolytic factors causing alveolar wall destruction and impaired lung recoil. In chronic bronchitis, chronic inflammation leads to mucus hypersecretion, ciliary dysfunction, and airway obstruction.
Treatment
- Asthma treatments often focus on relievers (SABA, SAMA, theophylline) and controllers (ICS, LABA). Biologics are reserved for severe cases.
- COPD treatments generally use the same short and long-acting beta-adrenergic agonists, long and short-acting antimuscarinics, and in some cases inhaled corticosteroids.
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Description
Test your knowledge on respiratory physiology with this quiz covering key concepts such as forced inhalation, gas exchange, and the functions of various respiratory structures. Questions explore conditions related to respiratory failure and the role of muscles in breathing. Perfect for students studying human biology or related fields.