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Questions and Answers
What is the main function of the respiratory system?
What is the main function of the respiratory system?
What is the characteristic feature of desquamative interstitial pneumonia?
What is the characteristic feature of desquamative interstitial pneumonia?
What is the final stage of idiopathic pulmonary fibrosis?
What is the final stage of idiopathic pulmonary fibrosis?
What is the prognosis of desquamative interstitial pneumonia?
What is the prognosis of desquamative interstitial pneumonia?
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What is the definition of respiratory failure?
What is the definition of respiratory failure?
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What is the characteristic feature of usual interstitial pneumonia?
What is the characteristic feature of usual interstitial pneumonia?
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What is the primary cause of idiopathic pulmonary fibrosis?
What is the primary cause of idiopathic pulmonary fibrosis?
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What is the complication of repeated exposure to idiopathic pulmonary fibrosis?
What is the complication of repeated exposure to idiopathic pulmonary fibrosis?
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What is the characteristic feature of the second stage of idiopathic pulmonary fibrosis?
What is the characteristic feature of the second stage of idiopathic pulmonary fibrosis?
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What is the clinical presentation of idiopathic pulmonary fibrosis?
What is the clinical presentation of idiopathic pulmonary fibrosis?
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Study Notes
Restrictive Pulmonary Disease
- Reduced lung parenchyma expansion due to thoracic cage abnormalities (neuromuscular problems, severe obesity, kyphoscoliosis) or intrinsic pulmonary causes (interstitial lung disease)
Causes of Restrictive Lung Disease
- Idiopathic interstitial fibrosis (most common)
- Occupational and environmental dust (coal, silica, asbestos, organic dust)
- Post-infectious
- Drugs and toxins
- Ionizing radiation, sarcoidosis, connective tissue diseases
Clinical Picture of Restrictive Lung Disease
- Progressive breathlessness
- Non-productive cough
- Chest X-ray shows patchy opacities in basal areas
Acute Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (DAD)
- Final common pathway for severe lung injuries
- Hyaline membranes lining alveoli in early DAD
- Interstitial inflammation and fibrosis
- High oxygen tensions needed to treat hypoxia, which can potentiate the disease
Pneumoconiosis
- Group of lung diseases resulting from inhalation of organic or inorganic dust
- Honeycomb lung is the end stage of most pneumoconiosis
- Factors determining type and extent of damage: physical and chemical properties of inhaled dust, concentration, duration of exposure, coexistence of other lung diseases
Coal Workers' Pneumoconiosis
- Inhalation of coal with low silica content
- Two stages: simple pneumoconiosis and progressive massive fibrosis
- Simple pneumoconiosis: dust particles engulfed by macrophages, local fibrotic reaction, obliteration of peribronchial alveoli and atrophy of bronchial smooth muscle
- Progressive massive fibrosis: massive confluent fibrosis of upper lobes, 10-20 years following exposure
Silicosis
- Inhalation of silica particles
- Engulfment by macrophages
- Discrete grayish-black fibrotic nodules
- Refractile silica particles surrounded by rings of fibrosis
- Obliteration of lumena of bronchioles and blood vessels with pleural adhesions
Asbestosis
- Inhalation of asbestos particles
- Asbestos is a carcinogenic agent, predisposing to mesothelioma
- Most famous types: white asbestos (chrysotile), blue asbestos (crocidolite), brown asbestos (amosite)
- Associated with building industry, shipping, and motor engine industry
- Amount of asbestos inhaled is the most important factor
- Fibers partially or completely engulfed by macrophages, coated by iron and proteins, appearing as drum sticks
Complications of Pneumoconiosis
- Secondary T.B (except asbestosis)
- Respiratory failure
- Right heart hypertrophy and failure
Extrinsic Allergic Alveolitis
- Due to inhalation of organic dust, causing local Arthus reaction (type III hypersensitivity reaction)
- Examples: Farmers' lung and Bird fancier's disease
- Clinically presents as episodes of fever, malaise, dyspnea, and basal crepitations
- Repeated exposure may induce lung fibrosis and end-stage honeycomb lung
Idiopathic Pulmonary Fibrosis
- Diagnosis by exclusion of other causes like extrinsic allergic alveolitis and pneumoconiosis
- Occurs in stages: alveolar exudation, interstitial inflammatory infiltration, interstitial fibroblastic proliferation, and progressive obliterative fibrosis
- Two forms: usual interstitial pneumonia and desquamative interstitial pneumonia
Respiratory Failure
- Defined as hypoxemia with arterial oxygen tension <60 mmHg
- Addition of O2 and removal of CO2 from circulating blood is the main function of the respiratory system
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Description
Learn about restrictive pulmonary diseases, respiratory failure, pneumoconiosis, and idiopathic pulmonary fibrosis, including causes and effects on the lung parenchyma and thoracic cage.
