Questions and Answers
What is the drug class of Reserpine?
What is the mechanism of Reserpine?
Indirect: Blocks uptake of NE, DOPA, & 5-HT into vesicles
What are the indications for using Reserpine?
Rarely used; mild-moderate hypertension
What effects does Reserpine have?
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Which of the following are common adverse reactions of Reserpine? (Select all that apply)
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Study Notes
Reserpine Overview
- Classified as an adrenergic antagonist, affecting the sympathetic nervous system by blocking adrenergic responses.
Mechanism of Action
- Acts indirectly by preventing the uptake of neurotransmitters: norepinephrine (NE), dopamine (DOPA), and serotonin (5-HT) into storage vesicles, leading to reduced availability of these neurotransmitters for release.
Clinical Indications
- Primarily indicated for the treatment of mild to moderate hypertension. However, its use is rare in modern practice due to the availability of more effective medications.
Therapeutic Effects
- Produces a gradual decrease in both blood pressure (BP) and cardiac output, contributing to its antihypertensive properties.
Adverse Reactions
- Associated with a wide range of side effects including:
- Nausea and gastric intolerance
- Abdominal cramps
- Weight gain
- Nasal congestion
- Depression
- Others may include sedation and gastrointestinal issues, underscoring the need for careful monitoring during treatment.
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Description
Test your knowledge on the pharmacology of Reserpine with these flashcards. Explore its drug class, mechanism, indications, effects, and adverse reactions. This quiz is essential for understanding this unique adrenergic antagonist.
