Research Project Design Overview

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Questions and Answers

What is a critical consideration when selecting a study design?

  • The study design should be based on personal preference.
  • The design should align with the existing ethical guidelines. (correct)
  • The design must use qualitative methods exclusively.
  • The design should have a strong historical precedent in research. (correct)

Which of the following elements is NOT typically included in defining a study design?

  • Data collection method
  • Financial viability (correct)
  • Endpoints and outcome measures
  • Population/sample

What is the purpose of having control measures in a study?

  • To maximize the number of participants
  • To simplify the study design process
  • To eliminate the need for ethical considerations
  • To enhance the interpretation of findings (correct)

Which method is least likely to be influenced by political considerations when designing a study?

<p>Clinical chart review (C)</p> Signup and view all the answers

What does a well-defined endpoint in research signify?

<p>A specific outcome of interest (D)</p> Signup and view all the answers

In the context of research design, what does the acronym PICO stand for?

<p>Population, Intervention, Control, Outcome (A), Problem, Intervention, Comparison, Outcome (D)</p> Signup and view all the answers

Which aspect is most critical in justifying the sample size for a research project?

<p>Statistical power and effect size (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of a well-defined study methodology?

<p>Flexibility to change methods as needed (A)</p> Signup and view all the answers

Which of the following best describes the primary purpose of quantitative research?

<p>To develop, refine, or test a theory using empirical data. (C)</p> Signup and view all the answers

What is a distinguishing feature of qualitative research methods compared to quantitative methods?

<p>Focus on subjective interpretations and meanings. (D)</p> Signup and view all the answers

Which type of analysis is primarily concerned with studying communication patterns?

<p>Content analysis (D)</p> Signup and view all the answers

In quantitative research, what does blinding aim to reduce?

<p>Bias in data collection and analysis. (C)</p> Signup and view all the answers

What type of research design specifically does not utilize randomization?

<p>Quasi-experimental research (A)</p> Signup and view all the answers

Which philosophical paradigm emphasizes a problem-centered approach and empirical observation?

<p>Post-positivism (D)</p> Signup and view all the answers

What type of research primarily focuses on generating hypotheses through the understanding of social phenomena?

<p>Qualitative research (A)</p> Signup and view all the answers

Which of the following research methodologies is generally associated with qualitative research?

<p>Phenomenology (B)</p> Signup and view all the answers

Which epistemological stance does NOT emphasize social/historical construction of knowledge?

<p>Post-positivism (A)</p> Signup and view all the answers

What is a defining characteristic of mixed methods research?

<p>combining qualitative and quantitative data (C)</p> Signup and view all the answers

Which of the following is not considered research 'with a capital R'?

<p>Service evaluation (C)</p> Signup and view all the answers

What does the term 'interpretivism' primarily focus on in research?

<p>Understanding multiple participant meanings (C)</p> Signup and view all the answers

Which characteristic defines qualitative research methods?

<p>Rigorous strategies for non-numerical data analysis (B)</p> Signup and view all the answers

What is the primary purpose of control groups in research studies?

<p>To provide a standard for comparison against the intervention (B)</p> Signup and view all the answers

In the context of sampling methods, which of the following is considered a non-probability sampling technique?

<p>Convenience sampling (C)</p> Signup and view all the answers

What distinguishes descriptive statistics from inferential statistics?

<p>Inferential statistics generalize findings from samples to populations (B)</p> Signup and view all the answers

What is the importance of power calculations in research design?

<p>To determine the minimum sample size required for detecting an effect (C)</p> Signup and view all the answers

What is the main goal of using patient-reported outcome measures in research?

<p>To capture the subjective experiences of patients related to their health (D)</p> Signup and view all the answers

Which of the following describes the process of saturation in qualitative research?

<p>Reaching a point where no new information is being obtained (B)</p> Signup and view all the answers

What role does Bonferroni adjustment play in research?

<p>It reduces the risk of Type I errors in multiple comparisons (D)</p> Signup and view all the answers

What is the primary challenge associated with pragmatic trials in naturalistic clinical settings?

<p>They typically require larger sample sizes due to confounding factors (C)</p> Signup and view all the answers

What is the primary purpose of a power calculation in quantitative research?

<p>To estimate the minimum sample size required to avoid type I and II errors (A)</p> Signup and view all the answers

Which of the following factors does NOT typically affect power calculations?

<p>Length of the research report (A)</p> Signup and view all the answers

Which of these types of studies involves the analysis of data collected from a specific population at a single point in time?

<p>Cross-sectional study (B)</p> Signup and view all the answers

What is the typical probability associated with a Type I error in clinical research?

<p>0.05 (D)</p> Signup and view all the answers

In the context of research resources, which of the following is considered a non-material resource?

<p>Expert advice (D)</p> Signup and view all the answers

The larger the sample size in a study, what effect does it generally have on the confidence interval?

<p>Narrower confidence interval due to increased precision (D)</p> Signup and view all the answers

What must researchers consider regarding the expected withdrawals and missing data while performing a power calculation?

<p>They should account for these factors to ensure sufficient sample size (B)</p> Signup and view all the answers

Which type of study design primarily evaluates the effect of an intervention by comparing outcomes between experimental and control groups?

<p>Experimental study (A)</p> Signup and view all the answers

Flashcards

Research Design

The blueprint or recipe for your research project. It outlines the specific methods, tools, and steps you will take to answer your research question.

Sample

The specific group of individuals your study aims to investigate. It's a subset of the larger population.

Sample Size Determination

The process of determining the appropriate number of participants needed to achieve reliable and meaningful results.

Data Collection Methods

The methods and resources you use to gather information, such as interviews, surveys, experiments, or observational studies.

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Endpoints and Outcome Measures

The specific criteria or outcomes that you will measure to evaluate the success of your research.

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Study Designs (e.g., Randomized Controlled Trial)

A specific method or strategy used to evaluate the effectiveness of an intervention or treatment. They often involve comparisons with a control group.

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Control Group

A group that receives no intervention or receives a standard treatment, allowing researchers to compare results with the experimental group.

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Study Conditions

The conditions or factors that affect your study, such as time, location, participant characteristics, or any potential biases.

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Transferability (generalisability)

The extent to which the results of a study can be generalized to other populations, settings, and times.

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Trustworthiness

The extent to which a study's results can be trusted to be accurate and reliable.

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Transparency

The openness and clarity of a study's methods and findings, allowing others to evaluate the study's rigor and validity.

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Validity

The extent to which a study measures what it intends to measure.

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Reliability

The consistency and reproducibility of a study's results.

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Constructivism

A research paradigm focusing on understanding the world as a social construction through interpretation and diverse perspectives.

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Post-positivism

A research paradigm that uses systematic procedures to test hypotheses and establish causal relationships.

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Quantitative research

A research approach that uses numerical data to test hypotheses and draw generalizations.

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Qualitative research

A research approach that explores the meaning-making processes and experiences of individuals and groups.

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Mixed methods research

A research methodology that combines both qualitative and quantitative data to provide a comprehensive understanding of a topic.

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Pragmatism

A philosophical perspective emphasizing the practical consequences and outcomes of research.

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Advocacy

A research paradigm where the researcher engages in the research process with the aim of promoting social change and empowering marginalized groups.

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Realism

A philosophical perspective that suggests that reality is objective and exists independently of human perception.

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Systematic Review

A systematic review summarizes the findings of multiple studies on a specific topic to provide a comprehensive overview and draw conclusions.

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Scoping Review

A scoping review is a type of review that explores the breadth and depth of a specific research area, identifying key concepts, gaps, and emerging themes.

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Power Calculation

Power calculations are used to determine the minimum sample size needed to achieve statistically significant results with a predetermined level of confidence.

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Variance (in Power Calculations)

The variance represents the spread or variability of data points within a study.

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Type I Error

Type I error occurs when you reject the null hypothesis (think of it as a false alarm) when it is actually true.

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Type II Error

Type II error occurs when you fail to reject the null hypothesis (think of it as missing something important) when it is actually false.

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Clinically Significant Difference

The clinically significant difference refers to the minimum difference between groups or treatments that is considered meaningful in a practical sense.

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Prevalence (in Power Calculations)

The prevalence of an event of interest refers to the proportion of individuals in a population who experience that event at a given time.

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Intention to treat analysis

A statistical analysis that includes all participants in a study, regardless of whether they completed the study or not. This method provides a more conservative and realistic estimate of the treatment effect.

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Descriptive statistics

Statistical methods used to describe and summarize data. Common examples include measures of central tendency (mean, median, mode) and dispersion (range, standard deviation).

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Inferential statistics

Statistical methods used to infer or draw conclusions about a population based on a sample of data. It involves testing hypotheses and making predictions.

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Intervention specification

A clearly defined plan or protocol that outlines the specific intervention being tested in a study.

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Control measures

Measures used in a study to minimize or control the influence of extraneous variables that could affect the results. This could be done through blinding, randomization, or controlled environments.

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Prospective study

A type of research study where data is collected prospectively (forward in time) to observe events and outcomes. This contrasts with retrospective studies, which look back at existing data.

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Between-groups comparison

The process of comparing data between different groups (e.g., treatment vs. control) to determine if there are significant differences. This is a key aspect of inferential statistics.

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Association analysis

To test if there is a relationship between two or more variables in a study. Analyzing the strength and direction of the relationship helps researchers draw conclusions about the association.

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Study Notes

Research Project Design

  • The lecture aims to develop an understanding of research design and its components, enabling students to define study designs, including all elements, based on a research question/problem.
  • Key steps in research design include: learning and differentiating common study designs, understanding sample size concepts, identifying necessary resources/sample size for a research project, and defining study conditions/control measures, endpoints, and outcome measures.
  • Students should be familiar with scientific theory, literature review, research questions (PICO/PEO/SPIDER), aims/objectives/hypotheses, population/sample, rationale/impact, data collection methods, definition of success/endpoints, and ethical considerations.
  • Design choices are influenced by constraints and opportunities related to logistics, practicality, and politics.
  • Designs should be guided by established strategy, methodology, and research paradigms (e.g., positivism).
  • A review of research knowledge and methods is recommended.

Meaningful Research

  • Research involves combining epistemology (knowledge) and ontology (science of how things are known).
  • Different philosophical paradigms (post-positivism/realism, pragmatism, pluralistic, interpretivism/relativism, advocacy, participatory) guide various approaches to research (quantitative, qualitative, mixed methods).

Research Strategies/Methodologies

  • Quantitative research (experimental, non-experimental) includes approaches like surveys, Quasi-experimental, Cross-sectional, Service evaluation, and Audit.

  • Qualitative research involves understanding individuals' social reality (e.g., attitudes, beliefs, motivations) through non-numerical, descriptive data, naturalistic observations, hypothesis generation/contextualisation. Rigorous and robust strategies and methods are important.

  • Qualitative research methods can include interviews, focus groups, diary methods, and observations. Thematic analysis (Braun & Clarke), content analysis, and discourse/conversation analysis are common qualitative analytical approaches.

  • Quantitative research methods often use randomisation, blinding of participants, use of valid assessment tools, and intention to treat analyses. Descriptive and inferential statistics are used, controlling interventions, and comparing outcomes (prospective and retrospective). Types of experimental research include randomised controlled trials, longitudinal studies, and cross-sectional studies.

Study Conditions/Trial Arms

  • Clear description of alternative interventions is crucial for reliability.
  • Comparisons should be made against control groups (e.g., usual care, placebo).
  • Appropriate control measures ensure only the intervention of interest is explored.
  • Optimal control of variables (laboratory type) versus pragmatic approaches in real-world settings.
  • The optimal strategy includes a balance between control and realistic implementation; consider potential confounding factors.

Outcome Measures and Endpoints

  • Outcome measures evaluate patients' reported outcomes.
  • Endpoints (e.g. clinical significance, survival rate) should be clearly defined.
  • Statistical significance, clinical significance, and relevant benchmarks (ambulance attendance, HCP contacts) should be considered.

Sample Size

  • Research questions must consider optimal and feasible sample sizes for research within undergraduate parameters.
  • Optimal sample size for different research types, ensuring scientific validity.
  • Understanding sample size that is logistically feasible to design an appropriate study.
  • Calculation of power (estimate of minimum sample size) is important to avoid Type I and II errors. Factors such as variance/standard deviation, sample size, clinical significance, and likelihood of type I or II errors are crucial factors in calculating power.

Research Resources

  • Research resources encompass time, travel, IT, expert advice, equipment, printing, administration, and venue.

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