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Questions and Answers
What hormone is primarily produced by the testes during male sexual development?
What hormone is primarily produced by the testes during male sexual development?
During puberty, the ovaries are capable of producing active reproductive cells called gametes.
During puberty, the ovaries are capable of producing active reproductive cells called gametes.
True
What are the two primary hormones released by the pituitary gland during puberty?
What are the two primary hormones released by the pituitary gland during puberty?
Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH)
The phase of the female reproductive cycle that involves the shedding of the uterine lining is called ______.
The phase of the female reproductive cycle that involves the shedding of the uterine lining is called ______.
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Match the following hormones with their function:
Match the following hormones with their function:
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At what average age does puberty onset typically occur for females?
At what average age does puberty onset typically occur for females?
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Only males produce sex hormones after birth.
Only males produce sex hormones after birth.
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What influence does GnRH have during puberty?
What influence does GnRH have during puberty?
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What is the primary mechanism of Progestin Only Pills (POP)?
What is the primary mechanism of Progestin Only Pills (POP)?
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Progestin Only Pills increase the risk of venous thromboembolism (VTE).
Progestin Only Pills increase the risk of venous thromboembolism (VTE).
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What is a common side effect experienced by users of Progestin Only Pills?
What is a common side effect experienced by users of Progestin Only Pills?
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Women should use a backup method for the first __ hours when starting Progestin Only Pills.
Women should use a backup method for the first __ hours when starting Progestin Only Pills.
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Match the following conditions with their corresponding WHO contraindication status for Progestin Only Pills:
Match the following conditions with their corresponding WHO contraindication status for Progestin Only Pills:
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What is a notable effect of estrogen on lipid levels?
What is a notable effect of estrogen on lipid levels?
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Progesterone depresses the central nervous system.
Progesterone depresses the central nervous system.
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Name one absolute contraindication to consider in rational drug selection.
Name one absolute contraindication to consider in rational drug selection.
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Which drug interactions can affect the use of oral contraceptives?
Which drug interactions can affect the use of oral contraceptives?
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All oral contraceptives have the same effectiveness.
All oral contraceptives have the same effectiveness.
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Match the side effects with their corresponding risks associated with oral contraceptive use:
Match the side effects with their corresponding risks associated with oral contraceptive use:
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What is one factor to consider based on patient’s need when selecting a contraceptive method?
What is one factor to consider based on patient’s need when selecting a contraceptive method?
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What is a characteristic of monophasic hormonal contraceptives?
What is a characteristic of monophasic hormonal contraceptives?
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Monophasic hormonal contraceptives help in reducing the risk of endometrial and ovarian cancer.
Monophasic hormonal contraceptives help in reducing the risk of endometrial and ovarian cancer.
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Name one non-contraceptive benefit of hormonal contraceptives.
Name one non-contraceptive benefit of hormonal contraceptives.
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One benefit of monophasic contraceptives is a reduction in ______ bleeding.
One benefit of monophasic contraceptives is a reduction in ______ bleeding.
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Match the non-contraceptive benefits of hormonal contraceptives with their descriptions:
Match the non-contraceptive benefits of hormonal contraceptives with their descriptions:
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What is the recommended action if a person does not get their period within three weeks after taking emergency contraception?
What is the recommended action if a person does not get their period within three weeks after taking emergency contraception?
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Uterine fibroids can disqualify someone from using an IUC depending on their location.
Uterine fibroids can disqualify someone from using an IUC depending on their location.
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What type of emergency contraceptive is preferred for individuals with a BMI greater than 35?
What type of emergency contraceptive is preferred for individuals with a BMI greater than 35?
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A ___________ is a procedure that permanently interrupts the vas deferens in men.
A ___________ is a procedure that permanently interrupts the vas deferens in men.
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Match the following contraceptive methods with their descriptions:
Match the following contraceptive methods with their descriptions:
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What should be done as soon as possible after taking emergency contraception?
What should be done as soon as possible after taking emergency contraception?
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Current purulent cervicitis is a poor candidate for an IUC.
Current purulent cervicitis is a poor candidate for an IUC.
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What is the maximum time frame in which Plan B can be taken after unprotected intercourse?
What is the maximum time frame in which Plan B can be taken after unprotected intercourse?
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Study Notes
Sexual Development
- Male and female embryos are identical in appearance until the 6th week of gestation.
- Both sexes develop reproductive organs from the same tissues.
- Steroid hormone production changes significantly in week 7:
- Testes produce androgens.
- Ovaries produce estrogens.
- After birth, testes and ovaries continue to produce small amounts of sex hormones, influencing reproductive organ development.
Puberty
- Puberty is a period of rapid growth and sexual maturation leading to functional reproductive systems.
- The onset of puberty varies but typically occurs between 9 and 15 years old, starting earlier in females.
- The Hypothalamus regulates GnRH secretion.
- GnRH stimulates the pituitary gland to produce FSH and LH.
Male Puberty
- FSH and LH stimulate testes to produce testosterone.
- Testosterone impacts secondary sex characteristics: voice deepening, beard growth, body hair, muscle mass.
- FSH and testosterone stimulate spermatogenesis.
Female Puberty
- FSH and LH stimulate ovaries to produce estrogen.
- Estrogen impacts secondary sex characteristics: breast enlargement, hip widening, body hair.
The Menstrual Cycle
- Three phases:
- Menstruation and the follicular phase.
- Ovulation.
- Luteal phase.
Estrogen and Progesterone
- Estrogen has positive effects on bone mass, triglycerides, and HDL-to-LDL ratios.
- Estrogen stimulates coagulation and fibrinolytic pathways.
- Progesterone increases body temperature and insulin levels.
- Progesterone may depress the central nervous system.
Oral Contraceptives (OCs)
- All oral contraceptives have similar effectiveness.
- Cost varies:
- Retail cost typically $30-~$70 per cycle.
- Generic OCs are available on $4 lists.
- IUDs have an expensive initial cost but may be lower overall.
- Patient variables should be considered, such as delivery preference and timing of subsequent pregnancy.
Rational Drug Selection for Oral Contraceptives
- Start with absolute contraindications.
- Consider:
- Bleeding patterns.
- Side effect profiles.
- Patient's need for discretion.
- Timing of a future pregnancy.
Drug Variables for Oral Contraceptives
- Drug interactions may occur with TB drugs, antiepileptic drugs, and St John’s Wort.
- OCs can impact lipid levels.
- Common adverse drug reactions (ADRs) include:
- Venous thromboembolism risk increases 3 to 5 times with OC use.
- Cholestatic jaundice.
- Benign hepatic neoplasms.
- Myocardial infarction.
- Stroke.
- Neurological migraines.
Progestin-Only Pills (POPs)
- Also known as “mini pills”.
- Suppress ovulation and thicken cervical mucus, making the endometrium unsuitable for implantation.
- Taken daily without free days.
- Highly effective and safe for most women, including those with contraindications to other CHCs.
- Common complaint is irregular bleeding.
- Other androgenic side effects include: nausea, weight changes, depression, fatigue, acne, hirsutism, and lipid and CHO effects.
- 3rd generation POPs (desogestrel and norgestimate) are considered the least androgenic.
World Health Organization (WHO) Contraindications for POPs
- Breastfeeding women < 6 weeks postpartum (USMEC 2).
- Current DVT or PE.
- Acute viral hepatitis or other liver disorders.
- Breast cancer.
- Not suitable for women who cannot tolerate irregular bleeding or amenorrhea.
- There is no increased risk of VTE with POPs.
Counseling for POPs
- Start during the first 5 days of the menstrual cycle or any day you are sure you are not pregnant.
- Use back-up methods for the first 48 hours.
- Take one pill daily at the same time (± 3 hours) with no breaks.
- If a pill is missed, take it as soon as you remember, even if it means taking two pills on the same day.
- Drug interactions: Rifampin, anticonvulsants, St. John’s Wort.
- Fertility returns after discontinuing the pill.
- Period changes are common.
Combined Oral Contraceptives (COCs)
- More than 75 million women worldwide rely on COCs.
- Safe for healthy, reproductive-aged, nonsmoking women.
- Initial pills (1960s) had high hormone doses.
- One formulation holds progestin constant while varying estrogen.
Monophasic Combined Oral Contraceptives
- Same amount of estrogen and progesterone for 21 days, followed by 7 placebo pills.
- Advantages: Less breakthrough bleeding, good for women sensitive to hormonal fluctuations.
- Encourage patients to log side effects, noting when they occur.
Non-Contraceptive Benefits of Oral Contraceptives
- Decreased dysmenorrhea, menstrual irregularities, and menstrual blood loss.
- Improved menstrual migraines.
- Lessening of acne and hirsutism.
- Fewer ovarian cysts.
- Significantly reduced endometrial and ovarian cancer risk.
- Lower incidence of benign breast conditions.
- Favorable bone impact.
- Suppression of endometriosis for women who do not desire pregnancy.
- Decreased fibroid risk.
Intrauterine Contraceptives (IUDs)
- Different types: Copper (ParaGard) or hormonal (Mirena, Skyla, Liletta, Kyleena).
- Effective for long periods (up to 10 years).
- Inserted by a healthcare provider.
- May cause cramping or bleeding.
- Long-term benefits include:
- Reduced risk of pelvic inflammatory disease (PID).
- Decreased menstrual bleeding.
- Reduced risk of endometrial cancer.
- Fibroid reduction with 5 years of continuous use.
Contraindications for IUDs
- Known or suspected pregnancy.
- Puerperal sepsis.
- Immediate post-septic abortion.
- Unexplained vaginal bleeding.
- Cervical or endometrial cancer.
- Uterine fibroids depending on location.
- Uterine distortion.
- Current purulent cervicitis.
- Pelvic TB.
Emergency Contraceptives
- Different types:
- Plan B™, Plan B One Step™, or Next Choice (progestin-only).
- Ulipristal (ella) 30mg (one dose, Rx-only).
- Education and counseling are essential:
- If the period does not start within 3 weeks, see the PCP for an exam and pregnancy test.
- Do not have unprotected sex during the days and weeks following treatment.
- Begin using a reliable method of birth control as soon as possible.
- Remember this is a difficult decision.
- Ulipristal is preferred for overweight women (BMI > 35).
Contraception - Sterilization
- Permanent method, common for those over 30 years old.
- Vasectomy: Interruption of the vas deferens.
- Local anesthesia, outpatient procedure.
- Tubal ligation:
- Mini-laparotomy technique.
- Ties, cuts, or newer transcervical inserts.
HIV and Contraceptives
- CHCs/POPs: Category 1-2.
- DMPA: 40% increased risk of HIV acquisition.
- IUDs: Category 2.
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Description
Test your knowledge on the hormones involved in male and female sexual development and the reproductive cycle. This quiz covers important aspects of puberty, hormone functions, and contraception methods like Progestin Only Pills. Challenge yourself and learn more about human reproductive health!