Repaglinide Pharmacology Flashcards
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Questions and Answers

What is the category class of repaglinide?

Meglitinides

What is the expected pharmacological action of repaglinide?

  • Decreases insulin resistance
  • Inhibits pancreatic function
  • Increases blood glucose levels
  • Stimulates insulin release (correct)
  • What is the therapeutic use of repaglinide?

    Type 2 DM

    What complications may occur when taking repaglinide?

    <p>Diarrhea</p> Signup and view all the answers

    How should repaglinide be administered?

    <p>Orally 30 minutes before meals</p> Signup and view all the answers

    What are some signs of hypoglycemia to monitor for when administering repaglinide?

    <p>Diaphoresis, tachycardia, fatigue, excessive hunger, tremors</p> Signup and view all the answers

    What should clients do if they skip a meal while taking repaglinide?

    <p>Skip a dose</p> Signup and view all the answers

    Clients should not exceed four doses of repaglinide per day.

    <p>True</p> Signup and view all the answers

    What are contraindications for using repaglinide?

    <p>Diabetic ketoacidosis</p> Signup and view all the answers

    Which conditions require precautions when using repaglinide?

    <p>Older adults</p> Signup and view all the answers

    What substances decrease the hypoglycemic effects of repaglinide?

    <p>Corticosteroids</p> Signup and view all the answers

    What indicates medication effectiveness for repaglinide?

    <p>No signs and symptoms of hyperglycemia</p> Signup and view all the answers

    Study Notes

    Repaglinide (Prandin) Overview

    • Category Class: Meglitinides, which stimulate insulin release from pancreatic islet cells.
    • Requires a functioning pancreas to be effective; hypoglycemia is rare.

    Expected Pharmacological Action

    • Acts similarly to sulfonylureas by promoting insulin secretion.
    • Insulin release correlates with blood glucose levels.
    • Ineffective for patients who do not respond to sulfonylureas.

    Therapeutic Use

    • Primarily prescribed for Type 2 Diabetes Mellitus (DM).

    Complications

    • Mild hypoglycemia, particularly in patients with liver impairments.
    • Common adverse reactions include nausea and diarrhea.

    Medication Administration

    • Administer orally 30 minutes before meals, three times a day.
    • Advise clients to skip doses if meals are skipped and to add doses for additional meals.
    • Do not exceed four doses per day.

    Interventions

    • Monitor for hypoglycemia symptoms: diaphoresis, tachycardia, fatigue, excessive hunger, tremors.
    • For conscious patients with hypoglycemia, provide 2-3 teaspoons of sugar, a glass of orange juice, honey, or corn syrup in water.
    • Oral glucose tablets can also be used.
    • For unconscious patients, administer IV glucose (D50W) or 1 mg glucagon subcutaneously/IM.
    • Monitor blood glucose every 15-20 minutes until normal levels are restored or symptoms resolve.
    • Observe for persistent nausea, vomiting, or diarrhea and report to healthcare provider (HCP).
    • Periodic CBC monitoring is recommended; report any decrease in counts to HCP.

    Client Education

    • Instruct intake 30 minutes before meals, up to three times daily.
    • Emphasize to skip doses if meals are missed and to adjust doses for added meals.
    • Caution against exceeding four doses per day.

    Contraindications

    • Not suitable for diabetic ketoacidosis, which results from very high blood glucose levels.

    Precautions

    • Use with caution in older adults and those with renal or hepatic dysfunction or systemic infections.
    • Avoid use in patients with liver, kidney, or endocrine disorders.

    Interactions

    • Increased hypoglycemic effects with gemfibrozil (Lopid), erythromycin, and chloramphenicol.
    • Decreased hypoglycemic effects with alcohol, corticosteroids, and rifampin (Rifadin).

    Medication Effectiveness

    • Indicated by the absence of signs and symptoms of hyperglycemia.

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    Description

    Test your knowledge on repaglinide, a medication used to manage diabetes. This quiz covers its pharmacological actions and category class. Perfect for students in pharmacology or nursing courses.

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