Podcast
Questions and Answers
What is the category class of repaglinide?
What is the category class of repaglinide?
Meglitinides
What is the expected pharmacological action of repaglinide?
What is the expected pharmacological action of repaglinide?
What is the therapeutic use of repaglinide?
What is the therapeutic use of repaglinide?
Type 2 DM
What complications may occur when taking repaglinide?
What complications may occur when taking repaglinide?
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How should repaglinide be administered?
How should repaglinide be administered?
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What are some signs of hypoglycemia to monitor for when administering repaglinide?
What are some signs of hypoglycemia to monitor for when administering repaglinide?
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What should clients do if they skip a meal while taking repaglinide?
What should clients do if they skip a meal while taking repaglinide?
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Clients should not exceed four doses of repaglinide per day.
Clients should not exceed four doses of repaglinide per day.
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What are contraindications for using repaglinide?
What are contraindications for using repaglinide?
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Which conditions require precautions when using repaglinide?
Which conditions require precautions when using repaglinide?
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What substances decrease the hypoglycemic effects of repaglinide?
What substances decrease the hypoglycemic effects of repaglinide?
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What indicates medication effectiveness for repaglinide?
What indicates medication effectiveness for repaglinide?
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Study Notes
Repaglinide (Prandin) Overview
- Category Class: Meglitinides, which stimulate insulin release from pancreatic islet cells.
- Requires a functioning pancreas to be effective; hypoglycemia is rare.
Expected Pharmacological Action
- Acts similarly to sulfonylureas by promoting insulin secretion.
- Insulin release correlates with blood glucose levels.
- Ineffective for patients who do not respond to sulfonylureas.
Therapeutic Use
- Primarily prescribed for Type 2 Diabetes Mellitus (DM).
Complications
- Mild hypoglycemia, particularly in patients with liver impairments.
- Common adverse reactions include nausea and diarrhea.
Medication Administration
- Administer orally 30 minutes before meals, three times a day.
- Advise clients to skip doses if meals are skipped and to add doses for additional meals.
- Do not exceed four doses per day.
Interventions
- Monitor for hypoglycemia symptoms: diaphoresis, tachycardia, fatigue, excessive hunger, tremors.
- For conscious patients with hypoglycemia, provide 2-3 teaspoons of sugar, a glass of orange juice, honey, or corn syrup in water.
- Oral glucose tablets can also be used.
- For unconscious patients, administer IV glucose (D50W) or 1 mg glucagon subcutaneously/IM.
- Monitor blood glucose every 15-20 minutes until normal levels are restored or symptoms resolve.
- Observe for persistent nausea, vomiting, or diarrhea and report to healthcare provider (HCP).
- Periodic CBC monitoring is recommended; report any decrease in counts to HCP.
Client Education
- Instruct intake 30 minutes before meals, up to three times daily.
- Emphasize to skip doses if meals are missed and to adjust doses for added meals.
- Caution against exceeding four doses per day.
Contraindications
- Not suitable for diabetic ketoacidosis, which results from very high blood glucose levels.
Precautions
- Use with caution in older adults and those with renal or hepatic dysfunction or systemic infections.
- Avoid use in patients with liver, kidney, or endocrine disorders.
Interactions
- Increased hypoglycemic effects with gemfibrozil (Lopid), erythromycin, and chloramphenicol.
- Decreased hypoglycemic effects with alcohol, corticosteroids, and rifampin (Rifadin).
Medication Effectiveness
- Indicated by the absence of signs and symptoms of hyperglycemia.
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Description
Test your knowledge on repaglinide, a medication used to manage diabetes. This quiz covers its pharmacological actions and category class. Perfect for students in pharmacology or nursing courses.