Renal Structure and Function Overview
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Questions and Answers

What is the primary function of the renal system?

  • Produce hormones only
  • Maintain a stable environment for cell and tissue metabolism (correct)
  • Produce red blood cells
  • Regulate blood sugar levels

Where is renin produced in the renal system?

  • By the juxtaglomerular apparatus (correct)
  • In the renal pelvis
  • In the renal medulla
  • By the glomerulus

Which component of the nephron is responsible for regulating glomerular blood flow?

  • Renal corpuscle
  • Bowman capsule
  • Podocytes
  • Mesangial cells (correct)

What is the function of the glomerular basement membrane in the nephron?

<p>Filter plasma filtrates (A)</p> Signup and view all the answers

Where is the juxtaglomerular apparatus located?

<p>Around the afferent arteriole where it meets the glomerulus (A)</p> Signup and view all the answers

What is the main function of podocytes in the nephron?

<p>Modulate filtration (C)</p> Signup and view all the answers

What is the glomerular capillary hydrostatic pressure responsible for?

<p>Driving filtrate into Bowman's space (B)</p> Signup and view all the answers

What is the average hydrostatic pressure in Bowman's space?

<p>10 mmHg (A)</p> Signup and view all the answers

Which component represents the osmotic pressure that non-permeable solutes exert within glomerular capillaries?

<p>Glomerular capillary oncotic pressure (B)</p> Signup and view all the answers

Where do proteins and non-permeable solutes typically end up under normal conditions?

<p>Not filtered in Bowman's space (C)</p> Signup and view all the answers

What happens to glomerular perfusion when arterial pressure decreases according to the myogenic mechanism?

<p>Glomerular perfusion decreases (C)</p> Signup and view all the answers

Which autoregulation mechanism is dependent on sodium chloride?

<p>Tubuloglomerular feedback (A)</p> Signup and view all the answers

What does the Renin-Angiotensin-Aldosterone system (RAAS) help increase?

<p>Systemic arterial pressure (B)</p> Signup and view all the answers

What stimulates aldosterone secretion by the adrenal cortex?

<p>(RAAS) (A)</p> Signup and view all the answers

(Sympathetic Nervous System) causes what to happen to decrease GFR?

<p>(Vasoconstriction) (B)</p> Signup and view all the answers

What happens to GFR when Angiotensin II constricts arterioles?

<p>Decreases GFR (A)</p> Signup and view all the answers

What is the main function of the proximal tubule?

<p>Secretion of sodium and potassium (D)</p> Signup and view all the answers

Which segment of the Loop of Henle is responsible for urea secretion?

<p>Thin segment (C)</p> Signup and view all the answers

What is the key function of the collecting duct?

<p>Reabsorption of water (D)</p> Signup and view all the answers

Which component plays a role in the concentration of urine?

<p>Distal Tubule (A)</p> Signup and view all the answers

What is the best indicator for estimating the Glomerular Filtration Rate (GFR)?

<p>Inulin (C)</p> Signup and view all the answers

What is required in order to estimate Renal Plasma Flow?

<p>Filtration and secretion but no reabsorption (A)</p> Signup and view all the answers

How does the net filtration pressure in the glomerulus change if Bowman Capsule hydrostatic pressure increases?

<p>Decreases (A)</p> Signup and view all the answers

What factor directly influences the total volume of fluid filtered by the glomeruli?

<p>Perfusion pressure of renal blood flow (B)</p> Signup and view all the answers

What happens to the clearance rate if a substance is filtered and secreted only?

<p><code>Cx</code> will increase by 1.5 times (D)</p> Signup and view all the answers

What is the primary function of tubular reabsorption?

<p>To move fluid and solutes from tubular lumen to peritubular capillaries (C)</p> Signup and view all the answers

What is the main difference between Nephrotic Syndrome and Nephritic Syndrome?

<p>Presence of hematuria in Nephritic Syndrome (B)</p> Signup and view all the answers

What is the pathophysiological mechanism leading to glomerular sclerosis and scarring in Acute Glomerulonephritis?

<p>Activation of complement system (C)</p> Signup and view all the answers

Which manifestation is characteristic of Chronic Glomerulonephritis?

<p>Proteinuria exceeding 3-5 grams/day (A)</p> Signup and view all the answers

What is a common treatment for Nephrotic Syndrome?

<p>Angiotensin-converting enzyme inhibitors (B)</p> Signup and view all the answers

In Acute Glomerulonephritis, what leads to the formation of immune complexes in the glomerulus?

<p>Cross-reaction with glomerular endothelial cells (A)</p> Signup and view all the answers

Which cellular change is NOT typically observed in Acute Glomerulonephritis?

<p>Narrowed capillary lumen (D)</p> Signup and view all the answers

What is a characteristic manifestation of Nephritic Syndrome?

<p>**hematuria with RBC casts (D)</p> Signup and view all the answers

**Decreased GFR in Acute Glomerulonephritis leads to:

<p>**Peripheral edema (B)</p> Signup and view all the answers

**Thickening of the glomerular basement membrane with increased permeability to proteins and RBCs is a characteristic feature of:

<p>**Nephrotic Syndrome (D)</p> Signup and view all the answers

**Formation of autoantibodies against double-stranded DNA and nucleosomes is associated with:

<p>**Lupus nephritis (A)</p> Signup and view all the answers

What is the most prevalent risk factor for kidney stones?

<p>Inadequate fluid intake (D)</p> Signup and view all the answers

Which type of kidney stone makes up 15% of all cases and is associated with alkaline urine and infection with urease producing bacteria?

<p>Struvite stones (A)</p> Signup and view all the answers

What is the mechanism by which urinary staghorn calculi form?

<p>Crystallization or aggregation (C)</p> Signup and view all the answers

Which pathogen is the most common cause of urinary tract infections?

<p>Escherichia coli (A)</p> Signup and view all the answers

What anatomical factor in females increases their susceptibility to urinary tract infections?

<p>Progesterone-mediated smooth muscle relaxation (C)</p> Signup and view all the answers

What is the hallmark feature of Acute Kidney Injury (AKI)?

<p>Elevated BUN and creatinine levels (C)</p> Signup and view all the answers

Which type of AKI is the most common cause of AKI?

<p>Prerenal (B)</p> Signup and view all the answers

What is the primary cause of Prerenal AKI?

<p>Renal hypoperfusion (C)</p> Signup and view all the answers

Which classification system is used for Acute Kidney Injury (AKI) staging?

<p>Risk, Injury, Failure, Loss, End-Stage (D)</p> Signup and view all the answers

What is the primary factor worsening Chronic Kidney Disease (CKD)?

<p>Proteinuria (C)</p> Signup and view all the answers

Which symptom is NOT associated with Chronic Kidney Disease (CKD)?

<p>**Frost and red eye (B)</p> Signup and view all the answers

**Uremia is characterized by elevated levels of which markers?

<p>$BUN$ and $Cr$ (D)</p> Signup and view all the answers

**Postrenal AKI is associated with which of the following disorders?

<p>**BPH and kidney stones (B)</p> Signup and view all the answers

**Chronic Kidney Disease (CKD) is defined as GFR less than what value for 3 months or more?

<p>$60$ mL/min/$1.73 m^2$ (D)</p> Signup and view all the answers

What is the primary mechanism leading to Oliguria in Prerenal AKI?

<p>Decreased renal blood flow and hypoperfusion (B)</p> Signup and view all the answers

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