Renal Replacement Therapies Overview
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Questions and Answers

What clinical manifestation is likely associated with an infection?

  • Dizziness
  • Loss of appetite
  • Shaking chills (correct)
  • Visual disturbances
  • What is the primary goal of the new approach to kidney transplantation described?

  • To enhance the recipient's immune response to infections
  • To prevent rejection without using immunosuppressive drugs (correct)
  • To eliminate the need for all medications post-surgery
  • To prevent the development of kidney disease
  • What does the process of injecting blood stem cells from the donor achieve?

  • It allows donor immune cells to attack the recipient's body
  • It directly restores kidney function without surgery
  • It completely eradicates the recipient's original immune cells
  • It helps establish a hybrid immune system recognizing the donor's organ (correct)
  • Which of the following actions is essential for hospital staff and visitors in infection control?

    <p>Performing careful hand washing consistently</p> Signup and view all the answers

    What should be monitored to determine if the new hybrid immune system is effective?

    <p>Mix of cells from both the recipient and the donor</p> Signup and view all the answers

    What is a key component of preoperative teaching for patients undergoing elective abdominal surgery?

    <p>Postoperative pulmonary hygiene</p> Signup and view all the answers

    Which immunosuppressive agent is known as Prograf?

    <p>FK-506</p> Signup and view all the answers

    What is the purpose of early ambulation in the preoperative phase?

    <p>To prevent postoperative complications</p> Signup and view all the answers

    What characteristic distinguishes hyperacute rejection from other types of rejection?

    <p>Rapid onset within 24 hours</p> Signup and view all the answers

    What is a primary complication associated with hemodialysis?

    <p>Disequilibrium Syndrome</p> Signup and view all the answers

    Which symptom is specifically associated with both acute rejection and infection?

    <p>Fever</p> Signup and view all the answers

    What is the main goal of postoperative management for a transplanted kidney?

    <p>Maintain homeostasis until functioning</p> Signup and view all the answers

    Which access method is NOT used for hemodialysis?

    <p>Peritoneum</p> Signup and view all the answers

    What dietary consideration is important for patients post-kidney transplant?

    <p>Increased protein to support kidney function</p> Signup and view all the answers

    What nursing intervention is essential to monitor during hemodialysis?

    <p>Check BP and pulse rate every 30-60 minutes</p> Signup and view all the answers

    What is the most reliable test for evaluating kidney transplant rejection?

    <p>Percutaneous renal biopsy</p> Signup and view all the answers

    Continuous Renal Replacement Therapy is most appropriate for which condition?

    <p>Acute or urgent conditions</p> Signup and view all the answers

    Which of the following is a characteristic of peritoneal dialysis?

    <p>Utilizes the peritoneum as a membrane</p> Signup and view all the answers

    What is one reason high-flux dialysis would be preferred?

    <p>It increases clearance of low- and mid-molecular-weight molecules</p> Signup and view all the answers

    What should be monitored in the dialysate during peritoneal dialysis?

    <p>Intake and output to minimize discomfort</p> Signup and view all the answers

    Which of the following symptoms indicates the necessity for hemodialysis in chronic conditions?

    <p>Uremic signs and symptoms</p> Signup and view all the answers

    Which symptom may indicate an infection during clinical assessments?

    <p>Shaking chills</p> Signup and view all the answers

    What is the primary novel technique being utilized in the prevention of rejection after kidney transplantation?

    <p>Multiple small doses of radiation targeting the immune system</p> Signup and view all the answers

    What effect does the injection of blood stem cells from the donor have on the recipient?

    <p>It helps create a hybrid immune system recognizing the donor's organ</p> Signup and view all the answers

    Which of the following practices is essential in infection control measures for hospital staff and visitors?

    <p>Careful hand washing</p> Signup and view all the answers

    How did the Stanford team determine that the new hybrid immune system would not attack the transplanted organ?

    <p>By testing the recipient’s immune cells against donor cells in the laboratory</p> Signup and view all the answers

    What is an appropriate indication for using Continuous Venovenous Hemofiltration (CVVH)?

    <p>Fluid overload due to oliguric kidney disease</p> Signup and view all the answers

    Which statement about kidney transplantation is correct?

    <p>Related living donors generally provide more successful transplant outcomes than cadaver donors.</p> Signup and view all the answers

    What preoperative evaluation is necessary for a patient undergoing kidney transplantation?

    <p>Tissue typing and blood typing</p> Signup and view all the answers

    What should be monitored to ensure safety during the insertion of a catheter for dialysis?

    <p>Signs of peritonitis and bleeding</p> Signup and view all the answers

    Which statement is true regarding the management of a patient in advanced dialysis procedures?

    <p>Signs of mental confusion and nausea should be monitored.</p> Signup and view all the answers

    Which symptom is associated with hyperacute rejection?

    <p>Tenderness at transplant site</p> Signup and view all the answers

    What is the primary reason for early ambulation in the preoperative phase?

    <p>To enhance postoperative recovery</p> Signup and view all the answers

    Which immunosuppressive agent is commonly used to prevent transplant rejection?

    <p>Azathioprine</p> Signup and view all the answers

    What is a key sign of acute rejection in kidney transplant recipients?

    <p>Oliguria</p> Signup and view all the answers

    What diagnostic tool is most reliable for evaluating rejection in kidney transplantation?

    <p>Percutaneous renal biopsy</p> Signup and view all the answers

    Which condition is managed with a tapering dosage of immunosuppressive agents?

    <p>Chronic rejection</p> Signup and view all the answers

    Which of the following indicates a need for monitoring blood pressure after kidney transplantation?

    <p>Increasing blood pressure</p> Signup and view all the answers

    What is not a common preoperative teaching focus for patients undergoing elective abdominal surgery?

    <p>Cosmetic surgery options</p> Signup and view all the answers

    Which condition is NOT a primary indication for initiating hemodialysis?

    <p>High blood pressure</p> Signup and view all the answers

    What is the primary purpose of using a high-flux dialysis membrane?

    <p>To enhance the removal of low- and mid-molecular-weight molecules</p> Signup and view all the answers

    Which of the following complications is associated with peritoneal dialysis?

    <p>Exit site infection</p> Signup and view all the answers

    During hemodialysis, how frequently should blood pressure and pulse rate be checked?

    <p>Every 30-60 minutes</p> Signup and view all the answers

    What is a key nursing intervention before initiating peritoneal dialysis?

    <p>Check for patency of the catheter</p> Signup and view all the answers

    Which type of dialysis access is primarily used in hemodialysis?

    <p>Arteriovenous fistula</p> Signup and view all the answers

    Which statement about fluid management in hemodialysis is accurate?

    <p>Fluid overload must be monitored and managed due to its complications.</p> Signup and view all the answers

    What is the typical duration of a hemodialysis session?

    <p>3 to 4 hours</p> Signup and view all the answers

    Study Notes

    Renal Replacement Therapies

    • Renal replacement therapies include hemodialysis, peritoneal dialysis, and continuous renal replacement therapy (acute/urgent and chronic/maintenance)
    • Hemodialysis: high and increasing potassium levels, fluid overload, impending pulmonary edema, increasing acidosis, pericarditis (uremic), advanced uremia
    • Chronic/Maintenance Hemodialysis: advanced CKD & ESKD, uremic signs & symptoms, hyperkalemia, fluid overload, general lack of well-being
    • Dialyzers: hollow-fiber devices with tiny capillary tubes, porous tubes acting as semipermeable membranes, constant flow of solution maintains concentration gradient facilitating waste exchange across membrane, removing and discarding waste in the dialysate solution, High-flux dialysis uses highly permeable membranes to increase clearance of low- and mid-molecular-weight molecules
    • Peritoneal Dialysis: uses the peritoneum, a 36-hour procedure
    • Hemodialysis Access: arteriovenous fistula, internal jugular/subclavian/femoral vein catheterization, arteriovenous graft
    • Hemodialysis Duration: 3 to 4 hours
    • Peritoneal Dialysis Duration: 36 hours
    • Complications for Hemodialysis: disequilibrium syndrome, hypotension, bleeding, exit-site infection, peritonitis, hernia, pulmonary complications
    • Complications for Peritoneal Dialysis: exit-site infection, peritonitis, hernia, pulmonary complications
    • Nursing Interventions for Hemodialysis: checking blood pressure and pulse every 30-60 minutes; weighing patient before and after dialysis, monitor intake and output, monitor for signs of disequilibrium syndrome, headache, hypertension, restlessness, mental confusion, and nausea; watch for signs of bleeding, avoiding taking blood pressure on AV fistula site, avoid blood extraction on AV fistula site, provide diversion activities throughout the dialysis process
    • Nursing Interventions for Peritoneal Dialysis: monitor vital signs and observe for changes in behavior, ensuring catheter patency; adding procaine HCI to dialysate to minimize discomfort, observing for signs of peritonitis, maintain aseptic technique during catheter insertion and throughout the procedure.
    • Continuous Renal Replacement Therapies: hemofilter, indications (acute or chronic kidney failure, fluid overload with oliguric kidney disease, high metabolic/nutritional needs), Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD)
    • Kidney Transplantation: from living donor or cadaver, transplanted kidney placed in iliac fossa anterior to iliac crest, ureters anastomosed to the ureter of the recipient
    • Preoperative Management: bringing patient's metabolic state to a normal level, complete physical examination, tissue typing, blood typing, antibody screening, assessing lower urinary tract for bladder neck function and ureteral reflux, ensuring patient is free from infection, psychological evaluation, corticosteroid evaluation, and hemodialysis before transplant
    • Preoperative Nursing Interventions: management like elective abdominal surgery, preoperative teaching (postoperative pulmonary hygiene, pain management options, dietary restrictions, intravenous and arterial lines, tubes, early ambulation)
    • Postoperative Management: maintaining homeostasis until transplanted kidney functioning well, immunosuppressive therapy (azathioprine, corticosteroids, cyclosporine, OKT3, Prograf, Mycophenolate), tapering immunosuppressive drugs over several weeks, patient must take anti-rejection medication
    • Rejection & Failure: Hyperacute rejection (within 24 hours, immediate antibody-mediated reaction, generalized glomerular capillary thrombosis, necrosis, immediate removal of organ), Acute rejection (within 3 to 14 days, tenderness at transplant site, decrease in serum creatinine, malaise, fever, oliguria, early recognition and immunosuppressant therapy), Chronic rejection (after, fatigue, generalized edema, anuria or decreased urine output, tenderness at transplant site, immunosuppressive therapy), diagnostic tools (ultrasound, percutaneous renal biopsy, X-ray)
    • Drugs: azathioprine, belatacept, cyclosporine, everolimus, mycophenolate mofetil, prednisone, sirolimus, tacrolimus
    • Postoperative Nursing Interventions: assessing for signs and symptoms of rejection, oliguria, edema, fever, increasing blood pressure, weight gain, swelling or tenderness over the transplanted kidney or graft, assessment of serum creatinine, BUN, leukocytes and platelets, distinction between infection and rejection
    • Monitoring for Infection: protecting client from hospital staff, visitors, and others with active infections, careful hand washing is imperative, face mask may be worn, clinical manifestations (shaking chills, fever, tachycardia, tachypnea, either an increase or a decrease in WBCs, or leukopenia), practice strict aseptic technique
    • Update: new research from Stanford University, new approach to prevent rejection without immunosuppressive drugs, transplantation with the usual process and addition steps, blood stem cells from the donor, immune cells recognize donor organ as friend, monitoring recipient's hybrid immune system, slowly weaning patient away from immunosuppressive drugs

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    Description

    This quiz provides a comprehensive overview of renal replacement therapies, including hemodialysis, peritoneal dialysis, and continuous renal replacement therapy. Explore critical concepts such as the mechanisms of dialysis, indications for treatment, and access methods for hemodialysis. Perfect for nursing students and healthcare professionals looking to deepen their understanding of kidney replacement options.

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