Renal and Cardiovascular Pharmacology: Vascular Volume and Hypertension
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Questions and Answers

What percentage of the human body is composed of water?

  • 50%
  • 90%
  • 67% (correct)
  • 75%

What is the primary function of antidiuretic hormone (ADH) in the kidneys?

  • Stimulating the insertion of aquaporins in kidney tubules (correct)
  • Increasing blood pressure
  • Reducing water reabsorption
  • Increasing heart rate

What triggers the production of antidiuretic hormone (ADH)?

  • Hypertension
  • Low blood pressure
  • Dehydration
  • Increased electrolyte concentration in the blood (correct)

What is the effect of antidiuretic hormone (ADH) on blood vessels?

<p>Vasoconstriction (B)</p> Signup and view all the answers

What is the primary role of aldosterone in regulating vascular volume?

<p>Regulating electrolyte balance (D)</p> Signup and view all the answers

What is the consequence of excessive water loss due to inadequate water intake or low blood volume?

<p>Increased electrolyte concentration (C)</p> Signup and view all the answers

What is the effect of inhibiting carbonic anhydrase in the proximal convoluted tubule on sodium reabsorption?

<p>Decreased Na+ reabsorption (D)</p> Signup and view all the answers

What is the result of decreased H+ formation due to carbonic anhydrase inhibition?

<p>Decreased H+/Na+ exchange by sodium–hydrogen antiporter 3 (D)</p> Signup and view all the answers

What is required for a sulfonamide to bind to carbonic anhydrase?

<p>An unsubstituted sulfonamide (B)</p> Signup and view all the answers

What is the risk of prolonged use of carbonic anhydrase inhibitors?

<p>Metabolic acidosis (C)</p> Signup and view all the answers

What is the primary use of acetazolamide?

<p>Treatment of glaucoma (B)</p> Signup and view all the answers

What percentage of carbonic anhydrase inhibition is required to produce meaningful diuresis?

<p>99% (A)</p> Signup and view all the answers

Which of the following antihypertensive drug classes acts on the sympathetic nervous system?

<p>Sympatholytic Drugs (C)</p> Signup and view all the answers

What is the main focus of the learning objectives for drugs controlling fluid volume?

<p>Chemotypes, Physicochemical properties, SAR, and PK (C)</p> Signup and view all the answers

Which of the following is NOT a subclass of sympatholytic drugs?

<p>Vasodilators (B)</p> Signup and view all the answers

What is the primary function of diuretics in the context of antihypertensive therapy?

<p>To control fluid volume (C)</p> Signup and view all the answers

Which of the following antihypertensive drug classes acts on the renin-angiotensin-aldosterone system?

<p>Angiotensin converting enzyme inhibitors (A)</p> Signup and view all the answers

What is the term for drugs that block the action of vasopressin, a hormone that regulates water reabsorption in the kidneys?

<p>Vasopressin antagonists (D)</p> Signup and view all the answers

What is the primary factor driving the prevalence rates of hypertension based on race/ethnicity in the US?

<p>Social determinants of health (C)</p> Signup and view all the answers

Which of the following is a fixed risk factor for developing hypertension?

<p>Family history (C)</p> Signup and view all the answers

What is the primary purpose of ambulatory blood pressure monitoring?

<p>To evaluate white-coat hypertension (B)</p> Signup and view all the answers

Approximately what percentage of hypertension cases are classified as essential or primary hypertension?

<p>92% (C)</p> Signup and view all the answers

Which of the following is a modifiable risk factor for developing hypertension?

<p>Drinking too much alcohol (A)</p> Signup and view all the answers

What is the typical cost of home blood pressure monitoring devices?

<p>$40-$100 (D)</p> Signup and view all the answers

What is a unique feature of angiotensin II receptor antagonists, such as losartan?

<p>They do not cause angioedema (B)</p> Signup and view all the answers

What is the primary function of renin in the RAAS cascade?

<p>Converting angiotensinogen to angiotensin I (B)</p> Signup and view all the answers

What is the specific sequence recognized by the catalytic site of renin?

<p>Pro7-Phe8-His9-Leu10-Val11-Ile12-His13-Asn14 (D)</p> Signup and view all the answers

What was a challenge in developing renin inhibitors?

<p>The large recognition element required for inhibition (A)</p> Signup and view all the answers

What was a common issue with peptidomimetic compounds developed as renin inhibitors?

<p>They were too large and had poor solubility (D)</p> Signup and view all the answers

What is the only FDA-approved, orally bioavailable transition-state renin inhibitor?

<p>Aliskiren (A)</p> Signup and view all the answers

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