Renal and Cardiovascular Pharmacology: Vascular Volume and Hypertension
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Questions and Answers

What percentage of the human body is composed of water?

  • 50%
  • 90%
  • 67% (correct)
  • 75%
  • What is the primary function of antidiuretic hormone (ADH) in the kidneys?

  • Stimulating the insertion of aquaporins in kidney tubules (correct)
  • Increasing blood pressure
  • Reducing water reabsorption
  • Increasing heart rate
  • What triggers the production of antidiuretic hormone (ADH)?

  • Hypertension
  • Low blood pressure
  • Dehydration
  • Increased electrolyte concentration in the blood (correct)
  • What is the effect of antidiuretic hormone (ADH) on blood vessels?

    <p>Vasoconstriction</p> Signup and view all the answers

    What is the primary role of aldosterone in regulating vascular volume?

    <p>Regulating electrolyte balance</p> Signup and view all the answers

    What is the consequence of excessive water loss due to inadequate water intake or low blood volume?

    <p>Increased electrolyte concentration</p> Signup and view all the answers

    What is the effect of inhibiting carbonic anhydrase in the proximal convoluted tubule on sodium reabsorption?

    <p>Decreased Na+ reabsorption</p> Signup and view all the answers

    What is the result of decreased H+ formation due to carbonic anhydrase inhibition?

    <p>Decreased H+/Na+ exchange by sodium–hydrogen antiporter 3</p> Signup and view all the answers

    What is required for a sulfonamide to bind to carbonic anhydrase?

    <p>An unsubstituted sulfonamide</p> Signup and view all the answers

    What is the risk of prolonged use of carbonic anhydrase inhibitors?

    <p>Metabolic acidosis</p> Signup and view all the answers

    What is the primary use of acetazolamide?

    <p>Treatment of glaucoma</p> Signup and view all the answers

    What percentage of carbonic anhydrase inhibition is required to produce meaningful diuresis?

    <p>99%</p> Signup and view all the answers

    Which of the following antihypertensive drug classes acts on the sympathetic nervous system?

    <p>Sympatholytic Drugs</p> Signup and view all the answers

    What is the main focus of the learning objectives for drugs controlling fluid volume?

    <p>Chemotypes, Physicochemical properties, SAR, and PK</p> Signup and view all the answers

    Which of the following is NOT a subclass of sympatholytic drugs?

    <p>Vasodilators</p> Signup and view all the answers

    What is the primary function of diuretics in the context of antihypertensive therapy?

    <p>To control fluid volume</p> Signup and view all the answers

    Which of the following antihypertensive drug classes acts on the renin-angiotensin-aldosterone system?

    <p>Angiotensin converting enzyme inhibitors</p> Signup and view all the answers

    What is the term for drugs that block the action of vasopressin, a hormone that regulates water reabsorption in the kidneys?

    <p>Vasopressin antagonists</p> Signup and view all the answers

    What is the primary factor driving the prevalence rates of hypertension based on race/ethnicity in the US?

    <p>Social determinants of health</p> Signup and view all the answers

    Which of the following is a fixed risk factor for developing hypertension?

    <p>Family history</p> Signup and view all the answers

    What is the primary purpose of ambulatory blood pressure monitoring?

    <p>To evaluate white-coat hypertension</p> Signup and view all the answers

    Approximately what percentage of hypertension cases are classified as essential or primary hypertension?

    <p>92%</p> Signup and view all the answers

    Which of the following is a modifiable risk factor for developing hypertension?

    <p>Drinking too much alcohol</p> Signup and view all the answers

    What is the typical cost of home blood pressure monitoring devices?

    <p>$40-$100</p> Signup and view all the answers

    What is a unique feature of angiotensin II receptor antagonists, such as losartan?

    <p>They do not cause angioedema</p> Signup and view all the answers

    What is the primary function of renin in the RAAS cascade?

    <p>Converting angiotensinogen to angiotensin I</p> Signup and view all the answers

    What is the specific sequence recognized by the catalytic site of renin?

    <p>Pro7-Phe8-His9-Leu10-Val11-Ile12-His13-Asn14</p> Signup and view all the answers

    What was a challenge in developing renin inhibitors?

    <p>The large recognition element required for inhibition</p> Signup and view all the answers

    What was a common issue with peptidomimetic compounds developed as renin inhibitors?

    <p>They were too large and had poor solubility</p> Signup and view all the answers

    What is the only FDA-approved, orally bioavailable transition-state renin inhibitor?

    <p>Aliskiren</p> Signup and view all the answers

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