Regulation of MMP2 and TIMP2 mRNA Levels in Myopia and Recovery
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Questions and Answers

What is the percentage change in mRNA levels for gelatinase A during myopia and after 24 hours of recovery from form deprivation?

  • 75% decrease during myopia, 12% of control after recovery
  • 125% increase during myopia, 50% of control after recovery (correct)
  • 75% decrease during myopia, 50% of control after recovery
  • 125% increase during myopia, 12% of control after recovery

    • What happens to the cornea when exposed to acid or alkaline substances and acted upon by MMPs?

  • Cornea becomes more opaque due to MMP action
  • Cornea weakens and perforates due to MMP action (correct)
  • Cornea remains unaffected by MMP action
  • Cornea strengthens due to MMP action

    • What is the effect on corneal ulceration when alkali-burned tissues are not exposed to any MMP inhibitor?

  • Immediate tissue regeneration
  • Maintained at a clinical score of approx. 1 for 15 days
  • Formation of a deep ulcer (correct)
  • Ulcer formation is inhibited

    • Which type of inhibitor is B mercaptomethyl-Leu-Phe-Ala, used to limit corneal ulceration?

    <p>SIMP synthetic inhibitor of metalloproteinase</p> Signup and view all the answers

    What is the percentage change in mRNA levels for TIMP-2 during myopia and 24 hours after stopping form deprivation?

    <p>125% increase during myopia, 75% after recovery</p> Signup and view all the answers

    What is the consequence of exposure to TIMP inhibitor on ulcer formation in corneas?

    <p>Ulcer formation is inhibited</p> Signup and view all the answers

    What is the effect on patients' esophoria when adding a +1.00 lens?

    <p>They become less esophoric</p> Signup and view all the answers

    When adding a -1.00 lens, what happens to the patients' exophoria?

    <p>They become more exophoric</p> Signup and view all the answers

    What is the relationship between plus lenses and accommodation?

    <p>Plus lenses relax accommodation</p> Signup and view all the answers

    Why do minus lenses make patients less exophoric?

    <p>Minus lenses stimulate convergence</p> Signup and view all the answers

    What does a high AC/A ratio indicate?

    <p>Increased accommodative convergence</p> Signup and view all the answers

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