Regulation of MMP2 and TIMP2 mRNA Levels in Myopia and Recovery
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Questions and Answers

What is the percentage change in mRNA levels for gelatinase A during myopia and after 24 hours of recovery from form deprivation?

  • 75% decrease during myopia, 12% of control after recovery
  • 125% increase during myopia, 50% of control after recovery (correct)
  • 75% decrease during myopia, 50% of control after recovery
  • 125% increase during myopia, 12% of control after recovery

What happens to the cornea when exposed to acid or alkaline substances and acted upon by MMPs?

  • Cornea becomes more opaque due to MMP action
  • Cornea weakens and perforates due to MMP action (correct)
  • Cornea remains unaffected by MMP action
  • Cornea strengthens due to MMP action

What is the effect on corneal ulceration when alkali-burned tissues are not exposed to any MMP inhibitor?

  • Immediate tissue regeneration
  • Maintained at a clinical score of approx. 1 for 15 days
  • Formation of a deep ulcer (correct)
  • Ulcer formation is inhibited

Which type of inhibitor is B mercaptomethyl-Leu-Phe-Ala, used to limit corneal ulceration?

<p>SIMP synthetic inhibitor of metalloproteinase (B)</p> Signup and view all the answers

What is the percentage change in mRNA levels for TIMP-2 during myopia and 24 hours after stopping form deprivation?

<p>125% increase during myopia, 75% after recovery (A)</p> Signup and view all the answers

What is the consequence of exposure to TIMP inhibitor on ulcer formation in corneas?

<p>Ulcer formation is inhibited (D)</p> Signup and view all the answers

What is the effect on patients' esophoria when adding a +1.00 lens?

<p>They become less esophoric (D)</p> Signup and view all the answers

When adding a -1.00 lens, what happens to the patients' exophoria?

<p>They become more exophoric (A)</p> Signup and view all the answers

What is the relationship between plus lenses and accommodation?

<p>Plus lenses relax accommodation (C)</p> Signup and view all the answers

Why do minus lenses make patients less exophoric?

<p>Minus lenses stimulate convergence (B)</p> Signup and view all the answers

What does a high AC/A ratio indicate?

<p>Increased accommodative convergence (D)</p> Signup and view all the answers
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