Regulation of MMP2 and TIMP2 mRNA Levels in Myopia and Recovery

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11 Questions

What is the percentage change in mRNA levels for gelatinase A during myopia and after 24 hours of recovery from form deprivation?

125% increase during myopia, 50% of control after recovery

What happens to the cornea when exposed to acid or alkaline substances and acted upon by MMPs?

Cornea weakens and perforates due to MMP action

What is the effect on corneal ulceration when alkali-burned tissues are not exposed to any MMP inhibitor?

Formation of a deep ulcer

Which type of inhibitor is B mercaptomethyl-Leu-Phe-Ala, used to limit corneal ulceration?

SIMP synthetic inhibitor of metalloproteinase

What is the percentage change in mRNA levels for TIMP-2 during myopia and 24 hours after stopping form deprivation?

125% increase during myopia, 75% after recovery

What is the consequence of exposure to TIMP inhibitor on ulcer formation in corneas?

Ulcer formation is inhibited

What is the effect on patients' esophoria when adding a +1.00 lens?

They become less esophoric

When adding a -1.00 lens, what happens to the patients' exophoria?

They become more exophoric

What is the relationship between plus lenses and accommodation?

Plus lenses relax accommodation

Why do minus lenses make patients less exophoric?

Minus lenses stimulate convergence

What does a high AC/A ratio indicate?

Increased accommodative convergence

Explore how MMP2 and TIMP2 mRNA levels change during myopia and after recovery. Learn about the influence of MMP2 and TIMP2 on tissue synthesis, and how their levels vary when form deprivation is discontinued. Dive into the regulation of these mRNA levels during myopia and recovery processes.

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