Podcast
Questions and Answers
What is the primary storage form of excess fructose in the liver?
What is the primary storage form of excess fructose in the liver?
- Glycogen
- Glucose
- Triglycerides (correct)
- Proteins
Fructose stimulates a significant insulin release, similar to glucose.
Fructose stimulates a significant insulin release, similar to glucose.
False (B)
What is the name of the lipoprotein that carries triglycerides from the liver to peripheral tissues?
What is the name of the lipoprotein that carries triglycerides from the liver to peripheral tissues?
Very-low-density lipoprotein (VLDL)
Fructose is a ______, the simplest form of carbohydrate.
Fructose is a ______, the simplest form of carbohydrate.
What is the primary fate of accumulated citrate in the liver during high fructose consumption?
What is the primary fate of accumulated citrate in the liver during high fructose consumption?
Match the following components to their roles in triglyceride synthesis from fructose:
Match the following components to their roles in triglyceride synthesis from fructose:
All cells in the body can utilize fructose for energy production as they do with glucose.
All cells in the body can utilize fructose for energy production as they do with glucose.
What is the name of the enzyme that converts citrate to acetyl CoA in the cytosol?
What is the name of the enzyme that converts citrate to acetyl CoA in the cytosol?
What is gluconeogenesis primarily used for in the human body?
What is gluconeogenesis primarily used for in the human body?
Gluconeogenesis occurs mainly in the pancreas.
Gluconeogenesis occurs mainly in the pancreas.
Name one type of molecule that can be used in gluconeogenesis.
Name one type of molecule that can be used in gluconeogenesis.
Gluconeogenesis is often referred to as ________ glucose production.
Gluconeogenesis is often referred to as ________ glucose production.
Which of the following is the first step of gluconeogenesis?
Which of the following is the first step of gluconeogenesis?
ATP is required in the process of gluconeogenesis.
ATP is required in the process of gluconeogenesis.
What is the end product of gluconeogenesis that is released into the bloodstream?
What is the end product of gluconeogenesis that is released into the bloodstream?
Match the following metabolic processes with their definitions:
Match the following metabolic processes with their definitions:
Which of the following fatty acids has an aliphatic tail of 6 to 12 carbons?
Which of the following fatty acids has an aliphatic tail of 6 to 12 carbons?
Saturated fatty acids contain one or more double bonds in their structure.
Saturated fatty acids contain one or more double bonds in their structure.
What is the common example of a saturated fatty acid mentioned?
What is the common example of a saturated fatty acid mentioned?
Very long chain fatty acids have aliphatic tails containing _____ or more carbons.
Very long chain fatty acids have aliphatic tails containing _____ or more carbons.
Which configuration of unsaturated fatty acids causes the chain to bend and restricts conformational freedom?
Which configuration of unsaturated fatty acids causes the chain to bend and restricts conformational freedom?
Match the following types of fatty acids with their characteristics:
Match the following types of fatty acids with their characteristics:
The trans configuration of unsaturated fatty acids allows the adjacent hydrogen atoms to lie on the same side of the chain.
The trans configuration of unsaturated fatty acids allows the adjacent hydrogen atoms to lie on the same side of the chain.
Name a fatty acid that is known for having a pronounced bend due to multiple cis double bonds.
Name a fatty acid that is known for having a pronounced bend due to multiple cis double bonds.
What is one way fatty acids are utilized in the body?
What is one way fatty acids are utilized in the body?
Fatty acids can only be used for energy storage and not for gene regulation.
Fatty acids can only be used for energy storage and not for gene regulation.
What are the two-carbon molecules generated from the breakdown of fatty acids called?
What are the two-carbon molecules generated from the breakdown of fatty acids called?
Fatty acids are transported intracellularly by _____ proteins.
Fatty acids are transported intracellularly by _____ proteins.
Match the fatty acid function with its description:
Match the fatty acid function with its description:
Which of the following indicates a saturated fatty acid?
Which of the following indicates a saturated fatty acid?
Fatty acids can be formed from glucose under conditions of excess energy.
Fatty acids can be formed from glucose under conditions of excess energy.
What are the specialized fat cells that store energy in the form of triacylglycerols called?
What are the specialized fat cells that store energy in the form of triacylglycerols called?
Which enzyme is responsible for converting fructose-6-phosphate to glucose-6-phosphate?
Which enzyme is responsible for converting fructose-6-phosphate to glucose-6-phosphate?
Gluconeogenesis primarily occurs in the skeletal muscle.
Gluconeogenesis primarily occurs in the skeletal muscle.
Name one enzyme that is unique to gluconeogenesis.
Name one enzyme that is unique to gluconeogenesis.
Fructose is a dietary monosaccharide that can be found in __________.
Fructose is a dietary monosaccharide that can be found in __________.
What is the primary function of gluconeogenesis?
What is the primary function of gluconeogenesis?
Match each enzyme to its respective function in gluconeogenesis:
Match each enzyme to its respective function in gluconeogenesis:
Uptake of fructose by the liver is regulated by insulin.
Uptake of fructose by the liver is regulated by insulin.
Glucose is formed from glucose-6-phosphate in the cell’s __________ via the enzyme glucose-6-phosphatase.
Glucose is formed from glucose-6-phosphate in the cell’s __________ via the enzyme glucose-6-phosphatase.
What is the first step in the catabolism of fructose?
What is the first step in the catabolism of fructose?
Fructose 1-phosphate is not further metabolized in the liver.
Fructose 1-phosphate is not further metabolized in the liver.
Which enzyme is responsible for splitting fructose 1-phosphate?
Which enzyme is responsible for splitting fructose 1-phosphate?
The triose __________ is produced from glyceraldehyde by triokinase.
The triose __________ is produced from glyceraldehyde by triokinase.
Match the enzymes with their functions in fructose metabolism:
Match the enzymes with their functions in fructose metabolism:
Which of the following statements is true regarding fructose metabolism?
Which of the following statements is true regarding fructose metabolism?
Glycogen synthesis from fructose is less efficient than from glucose.
Glycogen synthesis from fructose is less efficient than from glucose.
What happens to the intermediates of fructose metabolism once liver glycogen is replenished?
What happens to the intermediates of fructose metabolism once liver glycogen is replenished?
Flashcards
Gluconeogenesis
Gluconeogenesis
The process of creating new glucose molecules from non-carbohydrate sources.
Liver
Liver
The primary organ responsible for gluconeogenesis.
Glycolysis
Glycolysis
The process of breaking down glucose into its components.
Adenosine Triphosphate (ATP)
Adenosine Triphosphate (ATP)
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Oxaloacetate
Oxaloacetate
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PEPCK (Phosphoenolpyruvate Carboxykinase)
PEPCK (Phosphoenolpyruvate Carboxykinase)
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NADH
NADH
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Fructose-6-phosphate
Fructose-6-phosphate
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Fructolysis
Fructolysis
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Pyruvate carboxylase
Pyruvate carboxylase
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PEP carboxykinase
PEP carboxykinase
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Fructose 1,6-bisphosphatase
Fructose 1,6-bisphosphatase
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Glucose 6-phosphatase
Glucose 6-phosphatase
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Fructokinase
Fructokinase
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Galactokinase
Galactokinase
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Fructose metabolism in the liver
Fructose metabolism in the liver
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Fructose overload and triglyceride formation
Fructose overload and triglyceride formation
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Fructose metabolism and pyruvate buildup
Fructose metabolism and pyruvate buildup
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Citrate's role in fatty acid synthesis
Citrate's role in fatty acid synthesis
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DHAP and triglyceride synthesis
DHAP and triglyceride synthesis
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VLDL and triglyceride transport
VLDL and triglyceride transport
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Fatty acids: structure and function
Fatty acids: structure and function
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Fatty acid forms in organisms
Fatty acid forms in organisms
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Fatty Acid Metabolism
Fatty Acid Metabolism
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Fatty Acid-binding Proteins
Fatty Acid-binding Proteins
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Fatty Acid Oxidation
Fatty Acid Oxidation
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Triacylglycerols
Triacylglycerols
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Lipogenesis
Lipogenesis
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Unsaturated Fatty Acids
Unsaturated Fatty Acids
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Saturated Fatty Acids
Saturated Fatty Acids
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Essential Fatty Acids
Essential Fatty Acids
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Aldolase B
Aldolase B
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DHAP (dihydroxyacetone phosphate)
DHAP (dihydroxyacetone phosphate)
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Glyceraldehyde
Glyceraldehyde
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Triokinase
Triokinase
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Fructose as a better substrate for glycogen synthesis
Fructose as a better substrate for glycogen synthesis
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Fructose metabolism and triglyceride synthesis
Fructose metabolism and triglyceride synthesis
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Short-chain fatty acids (SCFA)
Short-chain fatty acids (SCFA)
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Medium-chain fatty acids (MCFA)
Medium-chain fatty acids (MCFA)
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Long-chain fatty acids (LCFA)
Long-chain fatty acids (LCFA)
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Very long chain fatty acids (VLCFA)
Very long chain fatty acids (VLCFA)
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Cis configuration
Cis configuration
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Trans configuration
Trans configuration
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Study Notes
Regulation of Energy Metabolism (Part 3)
- Gluconeogenesis is the creation of new glucose from non-carbohydrate sources.
- It's the opposite of glycolysis, which breaks down glucose.
- Gluconeogenesis primarily takes place in the liver, with smaller amounts occurring in the kidneys and small intestine.
- This process is important for maintaining blood sugar levels during periods without food intake (e.g., fasting or starvation).
Gluconeogenesis Pathway
- The pathway begins in the mitochondria or cytoplasm of the liver or kidneys.
- Two pyruvate molecules are carboxylated to form oxaloacetate, needing one ATP molecule.
- Oxaloacetate is reduced to malate by NADH for transport out of the mitochondria.
- Malate is oxidized back to oxaloacetate.
- Oxaloacetate forms phosphoenolpyruvate using the enzyme PEPC.
- Phosphoenolpyruvate converts to fructose-1,6-bisphosphate and then to fructose-6-phosphate
- Fructose-6-phosphate turns into glucose-6-phosphate with phosphoglucoisomerase.
- Glucose-6-phosphate is converted to glucose by the enzyme glucose-6-phosphatase in the endoplasmic reticulum.
- In this process ATP becomes ADP.
Gluconeogenesis Functions
- Human bodies produce glucose to maintain healthy blood sugar (for ATP production in cells).
- Gluconeogenesis happens when a person hasn't eaten in a while (during periods of starvation or prolonged exercise).
- The body utilizes molecules like amino acids, lactate, pyruvate, and glycerol when carbohydrate sources are limited.
- Glucose produced through gluconeogenesis is released into the bloodstream for energy use by other body parts.
- This process is also sometimes called endogenous glucose production (EGP).
Fructose Metabolism
- Fructose is a naturally occurring sugar found in fruits, vegetables, and sucrose.
- It is a monosaccharide.
- Fructose metabolism is different than glucose.
- The first step is phosphorylation of fructose to fructose-1-phosphate by fructokinase.
- Fructose-1-phosphate can be isomerized into glyceraldehyde-3-phosphate or converted into glycerol 3-phosphate. The resulting intermediate will be part of the gluconeogenic or fatty acid synthesis pathways.
- Fructolysis is a specific pathway for fructose breakdown.
- Fructose, unlike glucose, doesn't signal a substantial insulin release.
- Fructose is transported into cells via a different transporter than glucose.
Fatty Acids
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Fatty acids are carboxylic acids with long aliphatic chains.
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They can be saturated (no C=C double bonds) or unsaturated (one or more C=C double bonds, either cis or trans).
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Unsaturated fatty acids can have cis or trans configurations, affecting their rigidity and bendability.
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Unsaturated fatty acids with many cis bonds bend more.
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These are crucial components of cell membranes and triglycerides.
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Fatty acids are crucial for energy sources and storage.
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Fatty acid metabolism results in ATP production, gene expression, and the creation of different lipid classes for energy storage.
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The process begins with uptake of free fatty acids via fatty acid-binding proteins, activation to acyl-CoA and then transport to mitochondria or peroxisomes.
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