Regulation of Energy Metabolism Part 3

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Questions and Answers

What is the primary storage form of excess fructose in the liver?

  • Glycogen
  • Glucose
  • Triglycerides (correct)
  • Proteins

Fructose stimulates a significant insulin release, similar to glucose.

False (B)

What is the name of the lipoprotein that carries triglycerides from the liver to peripheral tissues?

Very-low-density lipoprotein (VLDL)

Fructose is a ______, the simplest form of carbohydrate.

<p>monosaccharide</p> Signup and view all the answers

What is the primary fate of accumulated citrate in the liver during high fructose consumption?

<p>Converted to acetyl CoA for fatty acid synthesis (B)</p> Signup and view all the answers

Match the following components to their roles in triglyceride synthesis from fructose:

<p>DHAP = Provides the glycerol backbone for the triglyceride molecule Acetyl CoA = Derived from citrate, used in fatty acid synthesis VLDL = Transports triglycerides from the liver to peripheral tissues Citrate = Intermediate in the Krebs cycle, transported from mitochondria to cytosol</p> Signup and view all the answers

All cells in the body can utilize fructose for energy production as they do with glucose.

<p>False (B)</p> Signup and view all the answers

What is the name of the enzyme that converts citrate to acetyl CoA in the cytosol?

<p>Citrate lyase</p> Signup and view all the answers

What is gluconeogenesis primarily used for in the human body?

<p>Synthesizing glucose from non-carbohydrate sources (B)</p> Signup and view all the answers

Gluconeogenesis occurs mainly in the pancreas.

<p>False (B)</p> Signup and view all the answers

Name one type of molecule that can be used in gluconeogenesis.

<p>Amino acids</p> Signup and view all the answers

Gluconeogenesis is often referred to as ________ glucose production.

<p>endogenous</p> Signup and view all the answers

Which of the following is the first step of gluconeogenesis?

<p>Carboxylation of pyruvate to form oxaloacetate (B)</p> Signup and view all the answers

ATP is required in the process of gluconeogenesis.

<p>True (A)</p> Signup and view all the answers

What is the end product of gluconeogenesis that is released into the bloodstream?

<p>Glucose</p> Signup and view all the answers

Match the following metabolic processes with their definitions:

<p>Gluconeogenesis = Synthesis of glucose from non-carbohydrate sources Glycolysis = Breakdown of glucose into components Endogenous Glucose Production = Internal glucose synthesis ATP = Energy currency of the cell</p> Signup and view all the answers

Which of the following fatty acids has an aliphatic tail of 6 to 12 carbons?

<p>Medium-chain fatty acids (B)</p> Signup and view all the answers

Saturated fatty acids contain one or more double bonds in their structure.

<p>False (B)</p> Signup and view all the answers

What is the common example of a saturated fatty acid mentioned?

<p>stearic acid</p> Signup and view all the answers

Very long chain fatty acids have aliphatic tails containing _____ or more carbons.

<p>22</p> Signup and view all the answers

Which configuration of unsaturated fatty acids causes the chain to bend and restricts conformational freedom?

<p>Cis configuration (B)</p> Signup and view all the answers

Match the following types of fatty acids with their characteristics:

<p>Short-chain fatty acids = Up to 5 carbons Medium-chain fatty acids = 6 to 12 carbons Long-chain fatty acids = 13 to 21 carbons Very long chain fatty acids = 22 or more carbons</p> Signup and view all the answers

The trans configuration of unsaturated fatty acids allows the adjacent hydrogen atoms to lie on the same side of the chain.

<p>False (B)</p> Signup and view all the answers

Name a fatty acid that is known for having a pronounced bend due to multiple cis double bonds.

<p>linoleic acid</p> Signup and view all the answers

What is one way fatty acids are utilized in the body?

<p>They are converted into ATP and heat. (D)</p> Signup and view all the answers

Fatty acids can only be used for energy storage and not for gene regulation.

<p>False (B)</p> Signup and view all the answers

What are the two-carbon molecules generated from the breakdown of fatty acids called?

<p>Acetyl-CoA</p> Signup and view all the answers

Fatty acids are transported intracellularly by _____ proteins.

<p>fatty acid-binding</p> Signup and view all the answers

Match the fatty acid function with its description:

<p>Signal-transduction pathways = Regulating cellular responses to signals Energy storage = Stored as triacylglycerols in adipose tissues Hormone composition = Essential components of hormone structure Modification of proteins = Changing protein function and activity</p> Signup and view all the answers

Which of the following indicates a saturated fatty acid?

<p>Contains only single carbon-to-carbon bonds (A)</p> Signup and view all the answers

Fatty acids can be formed from glucose under conditions of excess energy.

<p>True (A)</p> Signup and view all the answers

What are the specialized fat cells that store energy in the form of triacylglycerols called?

<p>Adipose tissue</p> Signup and view all the answers

Which enzyme is responsible for converting fructose-6-phosphate to glucose-6-phosphate?

<p>Phosphoglucoisomerase (B)</p> Signup and view all the answers

Gluconeogenesis primarily occurs in the skeletal muscle.

<p>False (B)</p> Signup and view all the answers

Name one enzyme that is unique to gluconeogenesis.

<p>Pyruvate carboxylase</p> Signup and view all the answers

Fructose is a dietary monosaccharide that can be found in __________.

<p>fruits and vegetables</p> Signup and view all the answers

What is the primary function of gluconeogenesis?

<p>To maintain blood glucose levels during fasting or exercise. (A)</p> Signup and view all the answers

Match each enzyme to its respective function in gluconeogenesis:

<p>Pyruvate carboxylase = Converts pyruvate to oxaloacetate PEP carboxykinase = Converts oxaloacetate to phosphoenolpyruvate Fructose 1,6-bisphosphatase = Converts fructose 1,6-bisphosphate to fructose 6-phosphate Glucose 6-phosphatase = Converts glucose-6-phosphate to glucose</p> Signup and view all the answers

Uptake of fructose by the liver is regulated by insulin.

<p>False (B)</p> Signup and view all the answers

Glucose is formed from glucose-6-phosphate in the cell’s __________ via the enzyme glucose-6-phosphatase.

<p>endoplasmic reticulum</p> Signup and view all the answers

What is the first step in the catabolism of fructose?

<p>Phosphorylation by fructokinase (A)</p> Signup and view all the answers

Fructose 1-phosphate is not further metabolized in the liver.

<p>False (B)</p> Signup and view all the answers

Which enzyme is responsible for splitting fructose 1-phosphate?

<p>Aldolase B</p> Signup and view all the answers

The triose __________ is produced from glyceraldehyde by triokinase.

<p>glyceraldehyde 3-phosphate</p> Signup and view all the answers

Match the enzymes with their functions in fructose metabolism:

<p>Fructokinase = Phosphorylates fructose Aldolase B = Splits fructose 1-phosphate Glycerol 3-phosphate dehydrogenase = Reduces DHAP to glycerol 3-phosphate Glyceraldehyde kinase = Converts glyceraldehyde to glyceraldehyde 3-phosphate</p> Signup and view all the answers

Which of the following statements is true regarding fructose metabolism?

<p>Fructose 1-phosphate needs to be hydrolyzed for further metabolism. (A)</p> Signup and view all the answers

Glycogen synthesis from fructose is less efficient than from glucose.

<p>False (B)</p> Signup and view all the answers

What happens to the intermediates of fructose metabolism once liver glycogen is replenished?

<p>They are directed toward triglyceride synthesis.</p> Signup and view all the answers

Flashcards

Gluconeogenesis

The process of creating new glucose molecules from non-carbohydrate sources.

Liver

The primary organ responsible for gluconeogenesis.

Glycolysis

The process of breaking down glucose into its components.

Adenosine Triphosphate (ATP)

The molecule that provides energy for the body's cells.

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Oxaloacetate

A key precursor molecule for gluconeogenesis, produced from pyruvate.

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PEPCK (Phosphoenolpyruvate Carboxykinase)

An enzyme involved in gluconeogenesis, converting oxaloacetate to phosphoenolpyruvate.

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NADH

The molecule that carries electrons in cellular respiration.

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Fructose-6-phosphate

A molecule that serves as an intermediate in gluconeogenesis, formed from fructose-1,6-biphosphate.

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Fructolysis

The process of breaking down fructose into simpler molecules.

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Pyruvate carboxylase

A key enzyme in gluconeogenesis that converts pyruvate to oxaloacetate, a precursor to glucose.

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PEP carboxykinase

An enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP), a crucial step in gluconeogenesis.

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Fructose 1,6-bisphosphatase

An enzyme that breaks down fructose 1,6-bisphosphate into fructose 6-phosphate, preventing the reverse reaction of glycolysis.

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Glucose 6-phosphatase

An enzyme that removes a phosphate group from glucose 6-phosphate to generate free glucose, the final step in gluconeogenesis.

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Fructokinase

A key enzyme in fructose metabolism that phosphorylates fructose to fructose 1-phosphate.

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Galactokinase

An enzyme that phosphorylates galactose to galactose 1-phosphate, the initial step in galactose metabolism.

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Fructose metabolism in the liver

Fructose, a simple sugar, bypasses normal glucose regulation and enters the liver directly.

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Fructose overload and triglyceride formation

High fructose intake can overwhelm liver capacity for glycogen storage, leading to triglyceride synthesis.

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Fructose metabolism and pyruvate buildup

Excess fructose is converted to pyruvate, which builds up in the liver.

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Citrate's role in fatty acid synthesis

Citrate, a Krebs cycle intermediate, is transported out of mitochondria and becomes a precursor for fatty acid synthesis.

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DHAP and triglyceride synthesis

DHAP (dihydroxyacetone phosphate), a glycolysis intermediate, is used to create the glycerol backbone of triglycerides.

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VLDL and triglyceride transport

Triglycerides are packaged into very low-density lipoproteins (VLDL) for transport from the liver.

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Fatty acids: structure and function

Fatty acids are long chains of carbon and hydrogen atoms, essential for energy storage and cell structure.

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Fatty acid forms in organisms

Triglycerides, phospholipids, and cholesteryl esters are the main forms in which fatty acids are found in organisms.

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Fatty Acid Metabolism

The process of breaking down fatty acids into two-carbon molecules, similar to those formed during glucose breakdown.

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Fatty Acid-binding Proteins

These proteins bind to fatty acids in the blood and transport them into cells.

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Fatty Acid Oxidation

The process of converting fatty acids into energy (ATP) within the mitochondria and peroxisomes.

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Triacylglycerols

These are lipids that act as energy storage in cells, primarily in adipose tissue.

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Lipogenesis

The process of converting glucose into fatty acids when there's excess glucose in a cell.

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Unsaturated Fatty Acids

These are fatty acids with one or more double bonds in their structure, making them more reactive.

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Saturated Fatty Acids

These are fatty acids with only single bonds in their structure, making them less reactive.

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Essential Fatty Acids

These are fatty acids that are essential for human health and cannot be synthesized by the body.

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Aldolase B

An enzyme that splits fructose 1-phosphate into DHAP (dihydroxyacetone phosphate) and glyceraldehyde.

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DHAP (dihydroxyacetone phosphate)

A molecule produced in fructolysis, it can be converted to glyceraldehyde 3-phosphate or glycerol 3-phosphate.

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Glyceraldehyde

A molecule produced in fructolysis, it needs phosphorylation to enter the glycolytic pathway.

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Triokinase

An enzyme that converts glyceraldehyde to glyceraldehyde 3-phosphate.

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Fructose as a better substrate for glycogen synthesis

Fructose can be used for glycogen synthesis instead of glucose, and glycogen replenishment takes priority over triglyceride formation.

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Fructose metabolism and triglyceride synthesis

Once liver glycogen stores are full, fructose metabolism primarily contributes to triglyceride synthesis.

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Short-chain fatty acids (SCFA)

Fatty acids with aliphatic tails of 5 or fewer carbons. For example, butyric acid.

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Medium-chain fatty acids (MCFA)

Fatty acids with aliphatic tails of 6 to 12 carbons. They can form medium-chain triglycerides.

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Long-chain fatty acids (LCFA)

Fatty acids with aliphatic tails of 13 to 21 carbons.

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Very long chain fatty acids (VLCFA)

Fatty acids with aliphatic tails of 22 or more carbons.

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Cis configuration

The two hydrogen atoms adjacent to the double bond are on the same side of the chain. This creates a bend in the fatty acid.

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Trans configuration

The two hydrogen atoms adjacent to the double bond are on opposite sides of the chain. The fatty acid remains relatively straight.

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Study Notes

Regulation of Energy Metabolism (Part 3)

  • Gluconeogenesis is the creation of new glucose from non-carbohydrate sources.
  • It's the opposite of glycolysis, which breaks down glucose.
  • Gluconeogenesis primarily takes place in the liver, with smaller amounts occurring in the kidneys and small intestine.
  • This process is important for maintaining blood sugar levels during periods without food intake (e.g., fasting or starvation).

Gluconeogenesis Pathway

  • The pathway begins in the mitochondria or cytoplasm of the liver or kidneys.
  • Two pyruvate molecules are carboxylated to form oxaloacetate, needing one ATP molecule.
  • Oxaloacetate is reduced to malate by NADH for transport out of the mitochondria.
  • Malate is oxidized back to oxaloacetate.
  • Oxaloacetate forms phosphoenolpyruvate using the enzyme PEPC.
  • Phosphoenolpyruvate converts to fructose-1,6-bisphosphate and then to fructose-6-phosphate
  • Fructose-6-phosphate turns into glucose-6-phosphate with phosphoglucoisomerase.
  • Glucose-6-phosphate is converted to glucose by the enzyme glucose-6-phosphatase in the endoplasmic reticulum.
  • In this process ATP becomes ADP.

Gluconeogenesis Functions

  • Human bodies produce glucose to maintain healthy blood sugar (for ATP production in cells).
  • Gluconeogenesis happens when a person hasn't eaten in a while (during periods of starvation or prolonged exercise).
  • The body utilizes molecules like amino acids, lactate, pyruvate, and glycerol when carbohydrate sources are limited.
  • Glucose produced through gluconeogenesis is released into the bloodstream for energy use by other body parts.
  • This process is also sometimes called endogenous glucose production (EGP).

Fructose Metabolism

  • Fructose is a naturally occurring sugar found in fruits, vegetables, and sucrose.
  • It is a monosaccharide.
  • Fructose metabolism is different than glucose.
  • The first step is phosphorylation of fructose to fructose-1-phosphate by fructokinase.
  • Fructose-1-phosphate can be isomerized into glyceraldehyde-3-phosphate or converted into glycerol 3-phosphate. The resulting intermediate will be part of the gluconeogenic or fatty acid synthesis pathways.
  • Fructolysis is a specific pathway for fructose breakdown.
  • Fructose, unlike glucose, doesn't signal a substantial insulin release.
  • Fructose is transported into cells via a different transporter than glucose.

Fatty Acids

  • Fatty acids are carboxylic acids with long aliphatic chains.

  • They can be saturated (no C=C double bonds) or unsaturated (one or more C=C double bonds, either cis or trans).

  • Unsaturated fatty acids can have cis or trans configurations, affecting their rigidity and bendability.

  • Unsaturated fatty acids with many cis bonds bend more.

  • These are crucial components of cell membranes and triglycerides.

  • Fatty acids are crucial for energy sources and storage.

  • Fatty acid metabolism results in ATP production, gene expression, and the creation of different lipid classes for energy storage.

  • The process begins with uptake of free fatty acids via fatty acid-binding proteins, activation to acyl-CoA and then transport to mitochondria or peroxisomes.

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