Physiology week 2

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Questions and Answers

What is the primary mechanism of calcium absorption in the small intestine?

  • Passive diffusion
  • Facilitated diffusion
  • Exocytosis
  • Active transport via calcium-binding protein (correct)

What is the primary function of 1,25-dihydroxyvitamin D in calcium homeostasis?

  • Inhibition of PTH secretion
  • Regulation of intestinal calcium absorption (correct)
  • Stimulation of osteoclast activity
  • Inhibition of osteoblast activity

What is the primary effect of PTH on osteoclasts?

  • Stimulation of osteoblast activity
  • Inhibition of osteoclast activity
  • Stimulation of osteoclast activity (correct)
  • Inhibition of osteoblast activity

Which hormone plays a major role in regulating bone formation and resorption?

<p>PTH (A)</p> Signup and view all the answers

What is the primary function of calcitonin in calcium homeostasis?

<p>Inhibition of osteoclast activity (C)</p> Signup and view all the answers

Which of the following is a consequence of hypocalcemia?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary stimulus for calcitonin secretion from parafollicular cells in the thyroid gland?

<p>Increased plasma Ca2+ concentration (C)</p> Signup and view all the answers

What is the effect of parathyroid hormone on phosphate reabsorption in the kidney?

<p>It inhibits phosphate reabsorption (C)</p> Signup and view all the answers

What is the role of vitamin D in intestinal calcium absorption?

<p>Vitamin D stimulates calcium absorption in the small intestine (B)</p> Signup and view all the answers

What is the effect of calcitonin on osteoclastic bone resorption?

<p>It inhibits osteoclastic bone resorption (D)</p> Signup and view all the answers

What is the effect of PTH on bone metabolism?

<p>It promotes bone resorption (A)</p> Signup and view all the answers

What is the relationship between calcitonin and PTH in terms of their effects on bone metabolism?

<p>They have antagonistic effects on bone metabolism (A)</p> Signup and view all the answers

What is the primary function of 1,25-dihydroxycholecalciferol in the small intestine?

<p>To increase the expression of calcium-binding proteins (C)</p> Signup and view all the answers

What is the effect of increased circulating levels of PTH on 1α-hydroxylase activity?

<p>It increases 1α-hydroxylase activity (C)</p> Signup and view all the answers

What is the primary role of vitamin D in bone metabolism?

<p>To stimulate osteoclast activity and promote bone resorption (C)</p> Signup and view all the answers

What is the consequence of vitamin D deficiency in children?

<p>Rickets (A)</p> Signup and view all the answers

What is the effect of 1,25-dihydroxycholecalciferol on phosphate reabsorption in the kidney?

<p>It stimulates phosphate reabsorption (D)</p> Signup and view all the answers

What is the stimulus for the production of the active metabolite of vitamin D in the kidney?

<p>Low dietary intake of calcium (B)</p> Signup and view all the answers

In which cell type does PTH bind to stimulate bone resorption?

<p>Osteoblasts (D)</p> Signup and view all the answers

What is the effect of PTH on osteoblast activity?

<p>PTH increases osteoblast activity (A)</p> Signup and view all the answers

What is the primary role of vitamin D in bone metabolism?

<p>Vitamin D increases calcium absorption in the intestine (A)</p> Signup and view all the answers

What is the consequence of PTH-mediated bone resorption?

<p>Release of calcium ions from the bone matrix (B)</p> Signup and view all the answers

What is the indirect mechanism by which PTH stimulates bone resorption?

<p>PTH induces the release of IL-6 and RANK ligand from osteoblasts (A)</p> Signup and view all the answers

In which tissue does PTH stimulate the activation of vitamin D?

<p>Kidney (B)</p> Signup and view all the answers

What is the effect of decreased plasma Ca2+ concentration on 1α-hydroxylase activity?

<p>It increases the activity of 1α-hydroxylase enzyme. (C)</p> Signup and view all the answers

What is the role of vitamin D in bone mineralization?

<p>It increases plasma levels of both Ca2+ and phosphate to promote mineralization of new bone. (D)</p> Signup and view all the answers

What is the consequence of vitamin D deficiency in adults?

<p>Osteomalacia, a condition in which new bone fails to mineralize, resulting in bending and softening of the weight-bearing bones. (B)</p> Signup and view all the answers

What is the role of osteoblasts in bone remodeling?

<p>They deposit new bone tissue, increasing bone mass. (B)</p> Signup and view all the answers

What is the effect of 1,25-dihydroxycholecalciferol on calcium absorption in the small intestine?

<p>It stimulates the formation of calcium-binding proteins, promoting calcium absorption. (D)</p> Signup and view all the answers

What is the role of 1,25-dihydroxycholecalciferol in bone mineralization?

<p>It promotes bone mineralization by stimulating osteoblast activity. (A)</p> Signup and view all the answers

What is the effect of PTH on phosphate reabsorption in the proximal convoluted tubule of the nephron?

<p>Inhibition of phosphate reabsorption (B)</p> Signup and view all the answers

What is the role of 1,25-dihydroxycholecalciferol in the small intestine?

<p>It stimulates calcium absorption in the small intestine (A)</p> Signup and view all the answers

What is the effect of PTH on bone metabolism?

<p>It stimulates osteoclast activity and bone resorption (B)</p> Signup and view all the answers

What is the consequence of vitamin D deficiency in children?

<p>Rickets (B)</p> Signup and view all the answers

What is the role of PTH in regulating vitamin D synthesis?

<p>It stimulates vitamin D synthesis (B)</p> Signup and view all the answers

What is the effect of vitamin D deficiency on bone metabolism?

<p>It leads to a decrease in osteoblast activity and bone formation (A)</p> Signup and view all the answers

What is the effect of increased circulating levels of PTH on 1α-hydroxylase enzyme activity?

<p>Stimulation of the enzyme (D)</p> Signup and view all the answers

Which of the following is the primary site of vitamin D synthesis?

<p>Skin and kidney (A)</p> Signup and view all the answers

What is the role of vitamin D in bone mineralization?

<p>Increase in both calcium and phosphate concentrations (B)</p> Signup and view all the answers

What is the effect of PTH on vitamin D synthesis?

<p>Stimulation of vitamin D synthesis (A)</p> Signup and view all the answers

What is the role of vitamin D in the small intestine?

<p>Increase in both calcium and phosphate absorption (C)</p> Signup and view all the answers

What is the primary function of vitamin D in conjunction with PTH?

<p>Regulation of both calcium and phosphate concentrations (B)</p> Signup and view all the answers

What is the primary stimulator of the 1α-hydroxylase enzyme activity?

<p>Decreased plasma calcium concentration (B)</p> Signup and view all the answers

What is the primary purpose of the regulation of vitamin D synthesis?

<p>To regulate plasma calcium levels (D)</p> Signup and view all the answers

What is the primary role of vitamin D in bone mineralization?

<p>To promote mineralization of new bone (C)</p> Signup and view all the answers

What is the effect of vitamin D on osteoclast activity?

<p>It increases osteoclast activity (D)</p> Signup and view all the answers

What is the consequence of vitamin D deficiency in children?

<p>Rickets (A)</p> Signup and view all the answers

What is the effect of 1,25-dihydroxycholecalciferol on calcium absorption in the small intestine?

<p>It increases calcium absorption (A)</p> Signup and view all the answers

What stimulates the activity of the 1α-hydroxylase enzyme in the kidney?

<p>Increase in parathyroid hormone levels (A)</p> Signup and view all the answers

What is the primary stimulus for the synthesis of 1,25-dihydroxycholecalciferol in the kidney?

<p>Decreased calcium levels (D)</p> Signup and view all the answers

What is the role of 1,25-dihydroxycholecalciferol in bone mineralization?

<p>Regulating calcium and phosphate metabolism (D)</p> Signup and view all the answers

What is the primary site of vitamin D synthesis?

<p>Skin (B)</p> Signup and view all the answers

What is the function of the 25-hydroxycholecalciferol-binding protein in plasma?

<p>Transporting vitamin D metabolites (C)</p> Signup and view all the answers

What is the effect of decreased calcium levels on vitamin D synthesis?

<p>Stimulating parathyroid hormone production (C)</p> Signup and view all the answers

What is the primary consequence of failing to comply with a medically prescribed steroid taper?

<p>Addisonian crisis (D)</p> Signup and view all the answers

What is the primary source of excess cortisol in Cushing's syndrome?

<p>Adrenal gland tumor (D)</p> Signup and view all the answers

What are the common symptoms of both Cushing's disease and Cushing's syndrome?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary cause of Cushing's disease?

<p>Pituitary adenoma (A)</p> Signup and view all the answers

What is the primary difference between Cushing's disease and Cushing's syndrome?

<p>The source of excess cortisol (B)</p> Signup and view all the answers

What is the primary mechanism of Adrenal Insufficiency in Addison's Disease?

<p>Autoimmune destruction of adrenal cortex (A)</p> Signup and view all the answers

What is the characteristic feature of Primary Hypercortisolism (Cushing's Syndrome)?

<p>Low ACTH levels and adrenal gland tumor (A)</p> Signup and view all the answers

What is the most common cause of Secondary Hypercortisolism (Cushing's Disease)?

<p>Pituitary tumor (A)</p> Signup and view all the answers

What is the hallmark of Iatrogenic Cushing's Syndrome?

<p>High Cortisol levels and low ACTH levels (B)</p> Signup and view all the answers

What is the threshold of adrenal cortex destruction required for Adrenal Insufficiency to occur?

<p>At least 90% of the adrenal cortex (C)</p> Signup and view all the answers

What is the characteristic feature of Secondary Adrenal Insufficiency (Hypopituitarism)?

<p>Low ACTH and low cortisol levels (D)</p> Signup and view all the answers

What is the primary symptom of adrenal insufficiency in women?

<p>Decreased libido and pubic hair (D)</p> Signup and view all the answers

What is the cause of secondary adrenal insufficiency?

<p>Lack of ACTH (D)</p> Signup and view all the answers

What is the effect of Addison's disease on cortisol levels?

<p>Decreased cortisol levels (B)</p> Signup and view all the answers

What is the treatment for Addison's disease?

<p>Replacement of glucocorticoids and mineralocorticoids (B)</p> Signup and view all the answers

What is the effect of Addison's disease on pubic and axillary hair in women?

<p>Decreased hair growth (C)</p> Signup and view all the answers

What is the cause of hyperkalemia in Addison's disease?

<p>Decreased aldosterone levels (D)</p> Signup and view all the answers

What is a consequence of chronic stress on the cardiovascular system?

<p>Left ventricular hypertrophy (C)</p> Signup and view all the answers

What is the primary mechanism by which chronic stress impairs immune function?

<p>Impaired immune surveillance (C)</p> Signup and view all the answers

Which of the following is a consequence of chronic stress on metabolism?

<p>Decreased glucose tolerance (A)</p> Signup and view all the answers

What is the primary effect of glucocorticoids on metabolism during chronic stress?

<p>Increased gluconeogenesis (C)</p> Signup and view all the answers

What is the primary consequence of chronic stress on the central nervous system?

<p>Impaired judgement and impulse control (C)</p> Signup and view all the answers

What is the primary effect of chronic stress on behavior?

<p>Increased irritability and hostility (A)</p> Signup and view all the answers

What is the term used to describe the state of balance and stability in an organism?

<p>Homeostasis (A)</p> Signup and view all the answers

Who is credited with the discovery of the 'fight or flight' response?

<p>Walter Cannon (B)</p> Signup and view all the answers

What is the term used to describe the deviation from a normal or steady state?

<p>Stress (A)</p> Signup and view all the answers

What is the name of the scientist who demonstrated that stress can alter an organism's resistance to disease?

<p>Louis Pasteur (B)</p> Signup and view all the answers

What is the term used to describe the system-wide arousal of the body in response to physical or psychological danger?

<p>Fight or flight response (A)</p> Signup and view all the answers

Who is credited with the discovery that stress can cause diseases?

<p>Galen (A)</p> Signup and view all the answers

What is associated with negative feelings and disturbed bodily states?

<p>Distress (B)</p> Signup and view all the answers

What is the effect of chronic GC exposure on adipose tissue function and lipid metabolism?

<p>Promotes insulin resistance (D)</p> Signup and view all the answers

What determines individual differences in stress sensitivity?

<p>All of the above (D)</p> Signup and view all the answers

What is the effect of chronic stress on the HPA axis?

<p>Enhanced susceptibility to activation (D)</p> Signup and view all the answers

What is associated with positive feelings and healthy bodily states?

<p>Eustress (C)</p> Signup and view all the answers

What is the effect of cortisol on insulin resistance?

<p>Promotes insulin resistance (A)</p> Signup and view all the answers

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