Regeneration and Repair in Tissue
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Questions and Answers

What is the primary mechanism of re-generation healing?

  • Hyperplasia of parenchymal cells
  • Proliferation of parenchymatous cells (correct)
  • Removal of the cause of inflammation
  • Proliferation of fibrous tissue

    • What is the characteristic feature of granulation tissue?

  • Appearance of pink/red granules (correct)
  • Formation of scar tissue
  • Proliferation of parenchymatous cells
  • Removal of the cause of inflammation

    • What is the primary difference between re-generation healing and repair?

  • Type of cell proliferation (correct)
  • Duration of the process
  • Rate of mitosis
  • Type of tissue involved

    • What is the term for an abnormal increase in the number of cells in an organ or tissue?

    <p>Hyperplasia</p> Signup and view all the answers

    What is the primary factor that determines the termination of inflammation?

    <p>All of the above</p> Signup and view all the answers

    What is the final stage of inflammation, where the tissue is restored to its original state?

    <p>Resolution</p> Signup and view all the answers

    Which of the following factors influences the termination of inflammation?

    <p>All of the above</p> Signup and view all the answers

    What is the primary role of PMNs in wound healing?

    <p>Scavenging the initial site of injury</p> Signup and view all the answers

    Which cells are involved in wound healing?

    <p>Leukocytes, macrophages, connective tissue cells, and epithelial cells</p> Signup and view all the answers

    What happens during the resolution stage of inflammation?

    <p>Removal of the inflammatory exudate and disposal of necrotic tissue</p> Signup and view all the answers

    What is the primary difference between regeneration and repair?

    <p>Regeneration restores normal tissue, while repair leads to scar formation</p> Signup and view all the answers

    What is an example of a small tissue defect that undergoes wound healing?

    <p>A small tissue defect caused by an endoscopic biopsy</p> Signup and view all the answers

    What is the primary function of fibronectin in wound healing?

    <p>To form a scaffold for tissue growth</p> Signup and view all the answers

    What is the most common form of collagen in the body?

    <p>Type I collagen</p> Signup and view all the answers

    What is required for the secretion of collagen?

    <p>Vitamin C and copper</p> Signup and view all the answers

    What type of collagen is typical of 'young' or 'immature' connective tissue?

    <p>Type III collagen</p> Signup and view all the answers

    What is the sequence of events in wound healing by primary union?

    <p>Coagulated blood forms a scab, followed by PMNs and then macrophages</p> Signup and view all the answers

    What type of wound healing occurs in clean cut wounds?

    <p>Healing by primary union</p> Signup and view all the answers

    What is the main effect of the cytokines and growth factors secreted by macrophages?

    <p>They promote the ingrowth of myofibroblasts, angioblasts, and fibroblasts</p> Signup and view all the answers

    What characterizes the temporary, makeshift structure that changes over time during the healing process?

    <p>It is rich in macrophages, myofibroblasts, angioblasts, and fibroblasts</p> Signup and view all the answers

    What happens to the interstitial spaces during the healing process?

    <p>They become edematous and are filled with matrix</p> Signup and view all the answers

    What is the final composition of the collagenous structure that forms during the healing process?

    <p>Predominantly type I collagen</p> Signup and view all the answers

    What happens to the myofibroblasts in the granulation tissue over time?

    <p>They decrease in number and eventually disappear</p> Signup and view all the answers

    What happens to the blood vessels in the granulation tissue over time?

    <p>They decrease in number and eventually collapse</p> Signup and view all the answers

    What is a characteristic of myofibroblasts that enables them to contract like muscle cells?

    <p>Their hybrid properties of smooth muscle cells and fibroblasts</p> Signup and view all the answers

    What is the primary function of newly formed blood vessels in the wound during the fifth or sixth day?

    <p>To provide a route for the scavenger cells to remove the scab and tissue debris</p> Signup and view all the answers

    What type of cells proliferate like sprouts from the several small blood vessels at the margins of the wound?

    <p>Angioblasts</p> Signup and view all the answers

    What is the result of the contraction of myofibroblasts that occurs within the first few days of healing?

    <p>The reduction of the defect and holding the margins of tissue in close approximation</p> Signup and view all the answers

    What type of cells are responsible for restoring the integrity of the surface epithelium?

    <p>Epithelial cells</p> Signup and view all the answers

    What is the primary function of myofibroblasts in the healing process?

    <p>To contract like muscle cells and hold the margins of tissue in close approximation</p> Signup and view all the answers

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