Regeneration and Repair in Tissue

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What is the primary mechanism of re-generation healing?

Hyperplasia of parenchymal cells

Proliferation of parenchymatous cells (correct)

Removal of the cause of inflammation

Proliferation of fibrous tissue

What is the characteristic feature of granulation tissue?

Appearance of pink/red granules (correct)

Formation of scar tissue

Proliferation of parenchymatous cells

Removal of the cause of inflammation

What is the primary difference between re-generation healing and repair?

Type of cell proliferation (correct)

Duration of the process

Rate of mitosis

Type of tissue involved

What is the term for an abnormal increase in the number of cells in an organ or tissue?

Hyperplasia Signup and view all the answers

What is the primary factor that determines the termination of inflammation?

All of the above Signup and view all the answers

What is the final stage of inflammation, where the tissue is restored to its original state?

Resolution Signup and view all the answers

Which of the following factors influences the termination of inflammation?

All of the above Signup and view all the answers

What is the primary role of PMNs in wound healing?

Scavenging the initial site of injury Signup and view all the answers

Which cells are involved in wound healing?

Leukocytes, macrophages, connective tissue cells, and epithelial cells Signup and view all the answers

What happens during the resolution stage of inflammation?

Removal of the inflammatory exudate and disposal of necrotic tissue Signup and view all the answers

What is the primary difference between regeneration and repair?

Regeneration restores normal tissue, while repair leads to scar formation Signup and view all the answers

What is an example of a small tissue defect that undergoes wound healing?

A small tissue defect caused by an endoscopic biopsy Signup and view all the answers

What is the primary function of fibronectin in wound healing?

To form a scaffold for tissue growth Signup and view all the answers

What is the most common form of collagen in the body?

Type I collagen Signup and view all the answers

What is required for the secretion of collagen?

Vitamin C and copper Signup and view all the answers

What type of collagen is typical of 'young' or 'immature' connective tissue?

Type III collagen Signup and view all the answers

What is the sequence of events in wound healing by primary union?

Coagulated blood forms a scab, followed by PMNs and then macrophages Signup and view all the answers

What type of wound healing occurs in clean cut wounds?

Healing by primary union Signup and view all the answers

What is the main effect of the cytokines and growth factors secreted by macrophages?

They promote the ingrowth of myofibroblasts, angioblasts, and fibroblasts Signup and view all the answers

What characterizes the temporary, makeshift structure that changes over time during the healing process?

It is rich in macrophages, myofibroblasts, angioblasts, and fibroblasts Signup and view all the answers

What happens to the interstitial spaces during the healing process?

They become edematous and are filled with matrix Signup and view all the answers

What is the final composition of the collagenous structure that forms during the healing process?

Predominantly type I collagen Signup and view all the answers

What happens to the myofibroblasts in the granulation tissue over time?

They decrease in number and eventually disappear Signup and view all the answers

What happens to the blood vessels in the granulation tissue over time?

They decrease in number and eventually collapse Signup and view all the answers

What is a characteristic of myofibroblasts that enables them to contract like muscle cells?

Their hybrid properties of smooth muscle cells and fibroblasts Signup and view all the answers

What is the primary function of newly formed blood vessels in the wound during the fifth or sixth day?

To provide a route for the scavenger cells to remove the scab and tissue debris Signup and view all the answers

What type of cells proliferate like sprouts from the several small blood vessels at the margins of the wound?

Angioblasts Signup and view all the answers

What is the result of the contraction of myofibroblasts that occurs within the first few days of healing?

The reduction of the defect and holding the margins of tissue in close approximation Signup and view all the answers

What type of cells are responsible for restoring the integrity of the surface epithelium?

Epithelial cells Signup and view all the answers

What is the primary function of myofibroblasts in the healing process?

To contract like muscle cells and hold the margins of tissue in close approximation Signup and view all the answers