30 Questions
What is the primary mechanism of re-generation healing?
Proliferation of parenchymatous cells
What is the characteristic feature of granulation tissue?
Appearance of pink/red granules
What is the primary difference between re-generation healing and repair?
Type of cell proliferation
What is the term for an abnormal increase in the number of cells in an organ or tissue?
Hyperplasia
What is the primary factor that determines the termination of inflammation?
All of the above
What is the final stage of inflammation, where the tissue is restored to its original state?
Resolution
Which of the following factors influences the termination of inflammation?
All of the above
What is the primary role of PMNs in wound healing?
Scavenging the initial site of injury
Which cells are involved in wound healing?
Leukocytes, macrophages, connective tissue cells, and epithelial cells
What happens during the resolution stage of inflammation?
Removal of the inflammatory exudate and disposal of necrotic tissue
What is the primary difference between regeneration and repair?
Regeneration restores normal tissue, while repair leads to scar formation
What is an example of a small tissue defect that undergoes wound healing?
A small tissue defect caused by an endoscopic biopsy
What is the primary function of fibronectin in wound healing?
To form a scaffold for tissue growth
What is the most common form of collagen in the body?
Type I collagen
What is required for the secretion of collagen?
Vitamin C and copper
What type of collagen is typical of 'young' or 'immature' connective tissue?
Type III collagen
What is the sequence of events in wound healing by primary union?
Coagulated blood forms a scab, followed by PMNs and then macrophages
What type of wound healing occurs in clean cut wounds?
Healing by primary union
What is the main effect of the cytokines and growth factors secreted by macrophages?
They promote the ingrowth of myofibroblasts, angioblasts, and fibroblasts
What characterizes the temporary, makeshift structure that changes over time during the healing process?
It is rich in macrophages, myofibroblasts, angioblasts, and fibroblasts
What happens to the interstitial spaces during the healing process?
They become edematous and are filled with matrix
What is the final composition of the collagenous structure that forms during the healing process?
Predominantly type I collagen
What happens to the myofibroblasts in the granulation tissue over time?
They decrease in number and eventually disappear
What happens to the blood vessels in the granulation tissue over time?
They decrease in number and eventually collapse
What is a characteristic of myofibroblasts that enables them to contract like muscle cells?
Their hybrid properties of smooth muscle cells and fibroblasts
What is the primary function of newly formed blood vessels in the wound during the fifth or sixth day?
To provide a route for the scavenger cells to remove the scab and tissue debris
What type of cells proliferate like sprouts from the several small blood vessels at the margins of the wound?
Angioblasts
What is the result of the contraction of myofibroblasts that occurs within the first few days of healing?
The reduction of the defect and holding the margins of tissue in close approximation
What type of cells are responsible for restoring the integrity of the surface epithelium?
Epithelial cells
What is the primary function of myofibroblasts in the healing process?
To contract like muscle cells and hold the margins of tissue in close approximation
Test your knowledge on the process of regeneration and repair in tissues, including the proliferation of parenchymatous cells and fibrous tissue. Learn about the differences between regeneration and repair, and their macroscopic and microscopic features.
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