5 Questions
Which of the following is the correct composition of red blood cells?
8% lipid, 40% carbohydrate, 52% protein
Which of the following biochemical changes is NOT associated with loss of red blood cell viability upon storage?
Increased ATP level
Which red blood cell preservative has a storage time of 35 days?
CPDA-1
Which of the following is NOT relatively permeable to the RBC membrane?
Water
What percentage of platelets is sequestered in the spleen as functional reserve after being released from the bone marrow?
30%
Study Notes
Red Blood Cell Composition
- Red blood cells are composed of a protein matrix, membranous lipids, and a high concentration of hemoglobin.
Biochemical Changes in Red Blood Cells
- Upon storage, red blood cells undergo various biochemical changes, including depletion of ATP and 2,3-DPG, increase in lactate levels, and oxidative stress, but NOT an increase in glutathione levels.
Red Blood Cell Preservatives
- CPDA-1 (citrate-phosphate-dextrose-adenine) is a red blood cell preservative with a storage time of 35 days.
Red Blood Cell Membrane Permeability
- RBC membranes are relatively impermeable to Na+ ions.
Platelet Sequestration
- Approximately 20-40% of platelets are sequestered in the spleen as a functional reserve after being released from the bone marrow.
Test your knowledge on red blood cell viability and preservation with this quiz. Answer questions about the biochemical changes associated with loss of red blood cell viability and identify the red blood cell preservative with a storage time of 35 days. Challenge yourself and learn more about red blood cell preservation.
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