Podcast
Questions and Answers
Which of the following is the correct composition of red blood cells?
Which of the following is the correct composition of red blood cells?
- 40% protein, 52% lipid, 8% carbohydrate
- 8% lipid, 40% carbohydrate, 52% protein (correct)
- 40% lipid, 8% carbohydrate, 52% protein
- 8% protein, 52% lipid, 40% carbohydrate
Which of the following biochemical changes is NOT associated with loss of red blood cell viability upon storage?
Which of the following biochemical changes is NOT associated with loss of red blood cell viability upon storage?
- Loss of red blood cell function
- Decreased pH
- Decreased glucose consumption
- Increased ATP level (correct)
Which red blood cell preservative has a storage time of 35 days?
Which red blood cell preservative has a storage time of 35 days?
- CPD
- ACD
- AS-1
- CPDA-1 (correct)
Which of the following is NOT relatively permeable to the RBC membrane?
Which of the following is NOT relatively permeable to the RBC membrane?
What percentage of platelets is sequestered in the spleen as functional reserve after being released from the bone marrow?
What percentage of platelets is sequestered in the spleen as functional reserve after being released from the bone marrow?
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Study Notes
Red Blood Cell Composition
- Red blood cells are composed of a protein matrix, membranous lipids, and a high concentration of hemoglobin.
Biochemical Changes in Red Blood Cells
- Upon storage, red blood cells undergo various biochemical changes, including depletion of ATP and 2,3-DPG, increase in lactate levels, and oxidative stress, but NOT an increase in glutathione levels.
Red Blood Cell Preservatives
- CPDA-1 (citrate-phosphate-dextrose-adenine) is a red blood cell preservative with a storage time of 35 days.
Red Blood Cell Membrane Permeability
- RBC membranes are relatively impermeable to Na+ ions.
Platelet Sequestration
- Approximately 20-40% of platelets are sequestered in the spleen as a functional reserve after being released from the bone marrow.
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