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Questions and Answers
What is a recombinant vaccine and how is it produced?
What is a recombinant vaccine and how is it produced?
A recombinant vaccine is a vaccine produced through recombinant DNA technology. It involves inserting the DNA encoding an antigen into cells, expressing the antigen, and purifying it from the cells.
What are the three groups of recombinant vaccines?
What are the three groups of recombinant vaccines?
The three groups of recombinant vaccines are subunit recombinant vaccines, attenuated recombinant vaccines, and vector recombinant vaccines.
What are subunit recombinant vaccines?
What are subunit recombinant vaccines?
Subunit recombinant vaccines are composed of components of the pathogenic organisms, such as proteins, peptides, and DNA.
What are attenuated recombinant vaccines?
What are attenuated recombinant vaccines?
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What are vector recombinant vaccines?
What are vector recombinant vaccines?
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Which type of recombinant vaccine involves inserting the DNA encoding an antigen into bacterial or mammalian cells?
Which type of recombinant vaccine involves inserting the DNA encoding an antigen into bacterial or mammalian cells?
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Which type of recombinant vaccine involves using genetically modified pathogenic organisms that are made non-pathogenic and used as vaccines?
Which type of recombinant vaccine involves using genetically modified pathogenic organisms that are made non-pathogenic and used as vaccines?
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Which type of recombinant vaccine involves using genetically modified viral vectors that can be used as vaccines against certain pathogens?
Which type of recombinant vaccine involves using genetically modified viral vectors that can be used as vaccines against certain pathogens?
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What are the components of subunit recombinant vaccines?
What are the components of subunit recombinant vaccines?
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What are the developments made in the production of recombinant vaccines against certain diseases?
What are the developments made in the production of recombinant vaccines against certain diseases?
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Study Notes
Recombinant Vaccines Overview
- Recombinant vaccines are designed by combining DNA from a pathogen with that of a non-pathogenic organism, resulting in a vaccine that can stimulate an immune response without causing disease.
Production of Recombinant Vaccines
- Produced by inserting target antigen genes into plasmids, which are then introduced into host cells (bacterial or mammalian) for protein expression.
- The cells produce the antigens that are harvested and purified for use in the vaccine.
Groups of Recombinant Vaccines
- Classified into three main groups:
- Subunit recombinant vaccines: Contain only specific antigens from the pathogen.
- Attenuated recombinant vaccines: Use modified pathogenic organisms rendered non-pathogenic.
- Vector recombinant vaccines: Employ genetically modified viral vectors to deliver antigens.
Subunit Recombinant Vaccines
- Made from isolated proteins or glycoproteins derived from the pathogen.
- Components may include:
- Purified antigens
- Adjuvants to enhance immune response
Attenuated Recombinant Vaccines
- Utilize genetically modified organisms that maintain some properties of the pathogen but are incapable of causing disease.
- Targeted for strong immune responses while minimizing risk.
Vector Recombinant Vaccines
- Use viral vectors, which are altered viruses that contain the desired antigen gene.
- The vector introduces the antigen gene into host cells, prompting an immune response.
Insertion of DNA Encoding Antigens
- Subunit recombinant vaccines involve inserting DNA encoding an antigen into bacterial or mammalian cells for protein production.
Use of Genetically Modified Pathogenic Organisms
- Attenuated recombinant vaccines involve genetically modified pathogenic organisms that are rendered non-pathogenic, providing safe vaccination options.
Genetically Modified Viral Vectors
- Vector recombinant vaccines utilize genetically modified viral vectors to deliver specific antigens from pathogens, eliciting an immune response without causing illness.
Developments in Recombinant Vaccine Production
- Significant advancements include improved techniques for producing antigens, enhanced delivery systems, and the ability to target a broader range of diseases.
- Continuous innovation aims to create vaccines that provide robust protection with fewer side effects.
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Description
Test your knowledge on recombinant vaccines and their production process in this informative quiz. Explore the different categories of recombinant vaccines and deepen your understanding of this fascinating technology.
