10 Questions
What is the purpose of using a pre-randomization run-in period in a clinical trial?
To maintain blinding and maximize compliance
What is a major advantage of a randomized cross-over design?
Each subject acts as his or her own control
Why should non-randomized and non-controlled trials be avoided?
Because of the increased likelihood of bias and confounding
What is a characteristic of a quasi-experimental design?
Participants are assigned to a study condition using a nonrandom but systematic procedure
What is an advantage of an RCT design?
It has high internal validity
What is a drawback of an RCT design?
It is time- and energy-intensive
What is the purpose of concealment in an RCT?
To reduce selection bias
What is a limitation of an RCT?
It cannot be used for rare outcomes
What is the key methodological component of an RCT?
Both use of a control condition and random assignment of participants to conditions
Why is random assignment of participants to conditions important in an RCT?
To reduce selection bias
Understand the basics of Randomized Controlled Trials (RCTs) and how to identify confounding variables in observational studies. Learn about study groups, treatment conditions, and controlling procedures. Review examples of confounding in observational studies.
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