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Questions and Answers
What is the purpose of using a pre-randomization run-in period in a clinical trial?
What is the purpose of using a pre-randomization run-in period in a clinical trial?
- To increase the duration of the study
- To introduce a placebo or active drug
- To maintain blinding and maximize compliance (correct)
- To reduce the sample size
What is a major advantage of a randomized cross-over design?
What is a major advantage of a randomized cross-over design?
- It takes shorter duration than parallel-group studies
- It requires a larger sample size
- Each subject acts as his or her own control (correct)
- It is more expensive than parallel-group studies
Why should non-randomized and non-controlled trials be avoided?
Why should non-randomized and non-controlled trials be avoided?
- Because they are time-consuming
- Because they require a larger sample size
- Because of the increased likelihood of bias and confounding (correct)
- Because they are expensive
What is a characteristic of a quasi-experimental design?
What is a characteristic of a quasi-experimental design?
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What is an advantage of an RCT design?
What is an advantage of an RCT design?
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What is a drawback of an RCT design?
What is a drawback of an RCT design?
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What is the purpose of concealment in an RCT?
What is the purpose of concealment in an RCT?
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What is a limitation of an RCT?
What is a limitation of an RCT?
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What is the key methodological component of an RCT?
What is the key methodological component of an RCT?
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Why is random assignment of participants to conditions important in an RCT?
Why is random assignment of participants to conditions important in an RCT?
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