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Questions and Answers
Which stage of tumor growth is characterized by cells that are no longer capable of cell division?
Which stage of tumor growth is characterized by cells that are no longer capable of cell division?
- Stage C (correct)
- Stage D
- Stage B
- Stage A
Which class of cytotoxic drugs acts by interfering with the biosynthesis of DNA and RNA?
Which class of cytotoxic drugs acts by interfering with the biosynthesis of DNA and RNA?
- Alkylating agents
- Antimetabolites (correct)
- Cytotoxic antibiotics
- Plant alkaloids/microtubule inhibitors
Which enzyme does Methotrexate (MTX) inhibit in the folate metabolism pathway?
Which enzyme does Methotrexate (MTX) inhibit in the folate metabolism pathway?
- Purine biosynthesis enzyme
- Tetrahydrofolate (THF) synthase
- Dihydrofolate reductase (DHFR) (correct)
- Methylene-THF reductase
What is the primary mechanism of action of Folate Antagonists like Methotrexate (MTX)?
What is the primary mechanism of action of Folate Antagonists like Methotrexate (MTX)?
Which cytotoxic drug class is structurally related to endogenous compounds in nucleic acid synthesis?
Which cytotoxic drug class is structurally related to endogenous compounds in nucleic acid synthesis?
Which stage of tumor growth involves cells that are resting but capable of division?
Which stage of tumor growth involves cells that are resting but capable of division?
What are the main classes of classical anticancer drugs described in the text?
What are the main classes of classical anticancer drugs described in the text?
What is the primary goal of ideal chemotherapy drugs according to the text?
What is the primary goal of ideal chemotherapy drugs according to the text?
What is the rationale for targeting the cell cycle/proliferation in classical chemotherapy?
What is the rationale for targeting the cell cycle/proliferation in classical chemotherapy?
Which approach to eliminating cancer involves the systemic or targeted use of drugs?
Which approach to eliminating cancer involves the systemic or targeted use of drugs?
What is the key feature that makes ideal chemotherapy drugs different from classical cytotoxics?
What is the key feature that makes ideal chemotherapy drugs different from classical cytotoxics?
Why is chemotherapy increasingly used in combination with surgery or radiation?
Why is chemotherapy increasingly used in combination with surgery or radiation?
What is the mechanism of action of 5-Fluorouracil (5-FU) in exerting its anticancer effects?
What is the mechanism of action of 5-Fluorouracil (5-FU) in exerting its anticancer effects?
Which enzyme is responsible for converting 5-Fluorouracil (5-FU) into its active metabolites?
Which enzyme is responsible for converting 5-Fluorouracil (5-FU) into its active metabolites?
What is the primary function of thymidylate synthase in DNA synthesis and repair?
What is the primary function of thymidylate synthase in DNA synthesis and repair?
Which of the following is NOT a purine analogue used as a nucleic acid synthesis inhibitor?
Which of the following is NOT a purine analogue used as a nucleic acid synthesis inhibitor?
What is the consequence of inhibiting thymidylate synthase in cells treated with 5-Fluorouracil (5-FU)?
What is the consequence of inhibiting thymidylate synthase in cells treated with 5-Fluorouracil (5-FU)?
Why are purine and pyrimidine analogues used as nucleic acid synthesis inhibitors?
Why are purine and pyrimidine analogues used as nucleic acid synthesis inhibitors?
How do Vinca alkaloids vincristine and vinblastine act to inhibit cell division?
How do Vinca alkaloids vincristine and vinblastine act to inhibit cell division?
Which of the following represents a common cause of failed therapy when using cytotoxic drugs?
Which of the following represents a common cause of failed therapy when using cytotoxic drugs?
What is the role of Taxanes like Paclitaxel in interfering with cell division?
What is the role of Taxanes like Paclitaxel in interfering with cell division?
How do resistant cells gain a selective advantage over sensitive cells during drug treatment?
How do resistant cells gain a selective advantage over sensitive cells during drug treatment?
Which is a mechanism of acquired drug resistance due to mutation in tumour cells?
Which is a mechanism of acquired drug resistance due to mutation in tumour cells?
In what way does Docetaxel interfere with mitosis to inhibit cell division?
In what way does Docetaxel interfere with mitosis to inhibit cell division?
Which class of cytotoxic drugs includes 5-fluorouracil (5-FU) and cytarabine (ara-C)?
Which class of cytotoxic drugs includes 5-fluorouracil (5-FU) and cytarabine (ara-C)?
What is the mechanism of action of methotrexate?
What is the mechanism of action of methotrexate?
Which drug is considered an alkylating-like agent?
Which drug is considered an alkylating-like agent?
Which class of cytotoxic drugs includes anthracyclines like doxorubicin?
Which class of cytotoxic drugs includes anthracyclines like doxorubicin?
What is the primary target of vinca alkaloids such as vincristine?
What is the primary target of vinca alkaloids such as vincristine?
Which drug inhibits DNA synthesis by acting as a folate antagonist?
Which drug inhibits DNA synthesis by acting as a folate antagonist?
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