Podcast Beta
Questions and Answers
Which stage of tumor growth is characterized by cells that are no longer capable of cell division?
Which class of cytotoxic drugs acts by interfering with the biosynthesis of DNA and RNA?
Which enzyme does Methotrexate (MTX) inhibit in the folate metabolism pathway?
What is the primary mechanism of action of Folate Antagonists like Methotrexate (MTX)?
Signup and view all the answers
Which cytotoxic drug class is structurally related to endogenous compounds in nucleic acid synthesis?
Signup and view all the answers
Which stage of tumor growth involves cells that are resting but capable of division?
Signup and view all the answers
What are the main classes of classical anticancer drugs described in the text?
Signup and view all the answers
What is the primary goal of ideal chemotherapy drugs according to the text?
Signup and view all the answers
What is the rationale for targeting the cell cycle/proliferation in classical chemotherapy?
Signup and view all the answers
Which approach to eliminating cancer involves the systemic or targeted use of drugs?
Signup and view all the answers
What is the key feature that makes ideal chemotherapy drugs different from classical cytotoxics?
Signup and view all the answers
Why is chemotherapy increasingly used in combination with surgery or radiation?
Signup and view all the answers
What is the mechanism of action of 5-Fluorouracil (5-FU) in exerting its anticancer effects?
Signup and view all the answers
Which enzyme is responsible for converting 5-Fluorouracil (5-FU) into its active metabolites?
Signup and view all the answers
What is the primary function of thymidylate synthase in DNA synthesis and repair?
Signup and view all the answers
Which of the following is NOT a purine analogue used as a nucleic acid synthesis inhibitor?
Signup and view all the answers
What is the consequence of inhibiting thymidylate synthase in cells treated with 5-Fluorouracil (5-FU)?
Signup and view all the answers
Why are purine and pyrimidine analogues used as nucleic acid synthesis inhibitors?
Signup and view all the answers
How do Vinca alkaloids vincristine and vinblastine act to inhibit cell division?
Signup and view all the answers
Which of the following represents a common cause of failed therapy when using cytotoxic drugs?
Signup and view all the answers
What is the role of Taxanes like Paclitaxel in interfering with cell division?
Signup and view all the answers
How do resistant cells gain a selective advantage over sensitive cells during drug treatment?
Signup and view all the answers
Which is a mechanism of acquired drug resistance due to mutation in tumour cells?
Signup and view all the answers
In what way does Docetaxel interfere with mitosis to inhibit cell division?
Signup and view all the answers
Which class of cytotoxic drugs includes 5-fluorouracil (5-FU) and cytarabine (ara-C)?
Signup and view all the answers
What is the mechanism of action of methotrexate?
Signup and view all the answers
Which drug is considered an alkylating-like agent?
Signup and view all the answers
Which class of cytotoxic drugs includes anthracyclines like doxorubicin?
Signup and view all the answers
What is the primary target of vinca alkaloids such as vincristine?
Signup and view all the answers
Which drug inhibits DNA synthesis by acting as a folate antagonist?
Signup and view all the answers