RBC Disorders: Porphyria, Hemoglobinopathies, Thalassemia Overview

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Which of the following components is NOT found in Drabkin's reagent used to measure hemoglobin from blood samples?

Sodium chloride

What is the role of potassium ferricyanide in measuring hemoglobin using Drabkin's reagent?

Converts hemoglobin iron from Fe++ to Fe+++

What does the color intensity of the mixture measured at a wavelength of 540 nm indicate in hemoglobin measurement?

Concentration of hemoglobin

Why can't HbF be used for hemoglobin determination in newborns?

It is resistant to alkali hematin

Which form of hemoglobin is NOT measured using the colorimetric method known as Acid Hematin (Sahli’s Method)?

Hemoglobin F

What is the purpose of potassium cyanide in the measurement of hemoglobin using Drabkin's reagent?

Forms cyanmethemoglobin with methemoglobin

Which type of blood leads to a false increase in hemoglobin levels when using the colorimetric method?

'Lipemic' blood

'Sulfhemoglobin' is excluded when measuring all forms of hemoglobin using which method?

'Drabkin's reagent'

'High WBC count' can lead to a false increase in hemoglobin levels due to what factor?

'Turbidity' in the sample

'Acid Hematin (Sahli’s Method)' uses which reagent for measuring hemoglobin concentration?

'0.1 N HCl'

Explore the rare inherited disorders related to porphyrias, hemoglobinopathies, and thalassemia, including the block in porphyrin synthesis and abnormalities in heme production. Learn about the classification based on clinical presentation and site of abnormal metabolism.

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