5 Questions
What happens during early G1 phase regarding RB and E2F?
RB binds to E2F and prevents transcription activation
What is one method by which RB blocks transcription?
Sequestering E2F and preventing it from interacting with other transcription activators
What happens during inactivation of RB gene?
RB is hyperphosphorylated, leading to release of E2F and DNA replication
What happens during reactivation of RB gene?
Phosphate groups are removed from hyperphosphorylated RB, regenerating active hypophosphorylated RB
What is a consequence of loss-of-function mutations involving both RB alleles?
Inactivation of RB and association with tumors like retinoblastomas and osteosarcomas
Test your knowledge of RB's role in blocking E2F-mediated transcription with this quiz. Explore how RB sequesters E2F and recruits enzymes to inhibit transcription during the early G1 phase. Learn about the consequences of RB gene inactivation.
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