RB and E2F Transcription Quiz
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Questions and Answers

What happens during early G1 phase regarding RB and E2F?

  • RB binds to E2F and prevents transcription activation (correct)
  • RB phosphorylates E2F to enhance transcription
  • RB dissociates from E2F to allow transcription activation
  • RB degrades E2F to inhibit transcription
  • What is one method by which RB blocks transcription?

  • Sequestering E2F and preventing it from interacting with other transcription activators (correct)
  • Promoting E2F nuclear localization for transcription activation
  • Enhancing E2F interaction with other transcription activators
  • Inhibiting E2F degradation to enhance transcription
  • What happens during inactivation of RB gene?

  • RB is dephosphorylated, leading to binding of E2F and DNA replication
  • RB is acetylated, leading to binding of E2F and DNA transcription
  • RB is degraded, leading to release of E2F and DNA transcription
  • RB is hyperphosphorylated, leading to release of E2F and DNA replication (correct)
  • What happens during reactivation of RB gene?

    <p>Phosphate groups are removed from hyperphosphorylated RB, regenerating active hypophosphorylated RB</p> Signup and view all the answers

    What is a consequence of loss-of-function mutations involving both RB alleles?

    <p>Inactivation of RB and association with tumors like retinoblastomas and osteosarcomas</p> Signup and view all the answers

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