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Questions and Answers
What happens during early G1 phase regarding RB and E2F?
What happens during early G1 phase regarding RB and E2F?
- RB binds to E2F and prevents transcription activation (correct)
- RB phosphorylates E2F to enhance transcription
- RB dissociates from E2F to allow transcription activation
- RB degrades E2F to inhibit transcription
What is one method by which RB blocks transcription?
What is one method by which RB blocks transcription?
- Sequestering E2F and preventing it from interacting with other transcription activators (correct)
- Promoting E2F nuclear localization for transcription activation
- Enhancing E2F interaction with other transcription activators
- Inhibiting E2F degradation to enhance transcription
What happens during inactivation of RB gene?
What happens during inactivation of RB gene?
- RB is dephosphorylated, leading to binding of E2F and DNA replication
- RB is acetylated, leading to binding of E2F and DNA transcription
- RB is degraded, leading to release of E2F and DNA transcription
- RB is hyperphosphorylated, leading to release of E2F and DNA replication (correct)
What happens during reactivation of RB gene?
What happens during reactivation of RB gene?
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What is a consequence of loss-of-function mutations involving both RB alleles?
What is a consequence of loss-of-function mutations involving both RB alleles?
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