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Questions and Answers
What is a Ramachandran plot used for in biochemistry?
What is a Ramachandran plot used for in biochemistry?
It is used to visualize energetically allowed regions for backbone dihedral angles ψ against φ of amino acid residues in protein structure.
Who developed the Ramachandran plot?
Who developed the Ramachandran plot?
G. N. Ramachandran, C. Ramakrishnan, and V. Sasisekharan
What does the ω angle at the peptide bond indicate?
What does the ω angle at the peptide bond indicate?
It indicates the partial-double-bond character that keeps the peptide bond planar.
How do the edges of the Ramachandran plot 'wrap'?
How do the edges of the Ramachandran plot 'wrap'?
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What are the different types of backbone conformational regions shown in the Ramachandran plot?
What are the different types of backbone conformational regions shown in the Ramachandran plot?
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What is a Ramachandran plot?
What is a Ramachandran plot?
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Who developed the Ramachandran plot?
Who developed the Ramachandran plot?
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What does the ω angle at the peptide bond indicate?
What does the ω angle at the peptide bond indicate?
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How do the edges of the Ramachandran plot 'wrap'?
How do the edges of the Ramachandran plot 'wrap'?
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What are the different types of backbone conformational regions shown in the Ramachandran plot?
What are the different types of backbone conformational regions shown in the Ramachandran plot?
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Study Notes
Ramachandran Plot
- A Ramachandran plot is a graphical representation of the dihedral angles of a polypeptide chain in a protein, used to visualize and analyze protein structure and conformation.
Development of the Ramachandran Plot
- The Ramachandran plot was developed by G.N. Ramachandran and his colleagues in 1963.
Peptide Bond and ω Angle
- The ω angle at the peptide bond indicates the planarity of the peptide bond, which is typically around 0° or 180°, indicating a planar or nearly planar arrangement.
Plot Edges and Wrapping
- The edges of the Ramachandran plot 'wrap' because the ϕ (phi) and ψ (psi) angles, which represent the dihedral angles of the polypeptide chain, are periodic, with values repeating every 360°.
Backbone Conformational Regions
- The Ramachandran plot shows different types of backbone conformational regions, including:
- α-helix region
- β-sheet region
- Coil region
- Disallowed regions
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Description
Test your knowledge of protein structure with this quiz on Ramachandran plots. Learn about the energetically allowed regions for backbone dihedral angles ψ and φ in amino acid residues.
