Radionuclide Evaluation of the Genitourinary System
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Questions and Answers

Which of the following is NOT a primary mechanism of the excretory function of the kidneys?

  • Passive filtration through the glomeruli
  • Ultrafiltration across the Bowman's capsule (correct)
  • Reabsorption of substances by the tubules
  • Active secretion by the tubules

According to the passage, what percentage of renal plasma flow is cleared by glomerular filtration?

  • 20% (correct)
  • 40%
  • 10%
  • 30%

Based on the information provided, which of the following imaging techniques is primarily used for evaluating renal anatomy?

  • Angiography
  • Computed tomography (CT)
  • Magnetic resonance imaging (MRI) (correct)
  • Radionuclide scanning

Which of the following is NOT mentioned as an indication for radionuclide scanning in the text?

<p>Evaluation of renal artery stenosis (D)</p> Signup and view all the answers

According to the passage, what percentage of renal plasma flow is cleared by tubular secretion?

<p>80% (B)</p> Signup and view all the answers

Which of the following imaging modalities is NOT mentioned in the passage as being widely used for evaluating renal anatomy?

<p>Positron emission tomography (PET) (A)</p> Signup and view all the answers

Which of the following is NOT a reason for omitting the renal perfusion phase of the renal scan?

<p>To contribute more to the functional assessment (C)</p> Signup and view all the answers

What is the typical duration of the renal parenchymal function phase imaging?

<p>20-30 minutes (A)</p> Signup and view all the answers

What is the purpose of administering the diuretic furosemide (Lasix) during the collecting system phase of the renal scan?

<p>To facilitate transit of activity from the renal pelvis and ureters to the bladder (A)</p> Signup and view all the answers

What is the purpose of obtaining postvoid or postambulation images during the collecting system phase of the renal scan?

<p>To enhance collecting system drainage (B)</p> Signup and view all the answers

What is the typical time frame for the classic renogram curve using tubular secretion radiopharmaceuticals like 99mTc-MAG3?

<p>0-30 minutes (A)</p> Signup and view all the answers

What is the purpose of the aortic region of interest in the renogram analysis?

<p>To assess the discreteness and adequacy of the injected bolus, as well as relative renal perfusion (C)</p> Signup and view all the answers

What is the typical duration of the initial renal perfusion or vascular transit phase of the renogram curve?

<p>30-60 seconds (B)</p> Signup and view all the answers

Which of the following is NOT a typical finding in the normal renogram curve using a tubular secretion radiopharmaceutical like 99mTc-MAG3?

<p>The kidneys appear larger on the early images compared to the later images (A)</p> Signup and view all the answers

Which of the following is NOT one of the three phases of the normal computer-generated renogram curve using a tubular radiopharmaceutical?

<p>Bladder filling phase (C)</p> Signup and view all the answers

What is the purpose of the background subtraction regions of interest in the renogram analysis?

<p>To subtract the activity in the surrounding tissues from the kidney regions of interest (A)</p> Signup and view all the answers

What is the purpose of scaling the graphical axes differently during renography?

<p>To evaluate the renal peak activity during the perfusion phase (C)</p> Signup and view all the answers

Which phase of renography is characterized by a down slope of the curve due to excretion of the radiopharmaceutical from the kidney?

<p>Clearance or excretion phase (A)</p> Signup and view all the answers

What may occur in a renogram curve if a patient is dehydrated during the renography?

<p>Delayed peak activity (A)</p> Signup and view all the answers

What is a common indicator used for quantitative assessment of renal function in radionuclide techniques?

<p>Half-time excretion (B)</p> Signup and view all the answers

In normal renograms, what is considered a normal value for the time to peak activity (Tmax)?

<p>Within 5 minutes after injection (A)</p> Signup and view all the answers

What renal function measure involves expresssing clearances as volume of plasma?

<p>$GFR$ and $ERPF$ (D)</p> Signup and view all the answers

Why should patients be well hydrated before a functional renal imaging examination?

<p>To enhance the visualization of renal excretion during the procedure (A)</p> Signup and view all the answers

What is the purpose of administering furosemide during functional renal imaging?

<p>To induce diuresis and overcome fixed anatomic obstructions (C)</p> Signup and view all the answers

Why is it important to empty the bladder before administering furosemide during the examination?

<p>To reduce the risk of a false appearance of obstruction (D)</p> Signup and view all the answers

In patients who cannot empty their bladders, what intervention may be used during the examination?

<p>Perform a bladder catheterization (C)</p> Signup and view all the answers

What is the role of real-time visual inspection in functional renal imaging?

<p>Identifying when the collecting systems are full (D)</p> Signup and view all the answers

Why is the timing of furosemide injection considered critical during functional renal imaging?

<p>To determine when the collecting systems are full (D)</p> Signup and view all the answers

Which of the following radiopharmaceuticals is primarily excreted through tubular secretion?

<p>99mTc-DMSA (A)</p> Signup and view all the answers

What percentage of the injected dose of 99mTc-glucoheptonate remains bound to the renal tubules?

<p>15% (D)</p> Signup and view all the answers

Which of the following statements about 99mTc-DMSA is NOT true?

<p>It is primarily excreted in the urine during the first several hours. (A)</p> Signup and view all the answers

What is the primary purpose of using 99mTc-DTPA in renal evaluation?

<p>Evaluating glomerular filtration function (C)</p> Signup and view all the answers

Which of the following statements about 99mTc-glucoheptonate is true?

<p>It is stable and may be used for up to 5 hours after preparation. (C)</p> Signup and view all the answers

What is the approximate percentage of the injected dose of 99mTc-DMSA concentrated in the renal cortex at 6 hours?

<p>40% (A)</p> Signup and view all the answers

Which of the following radiopharmaceuticals requires delayed images 1 to 3 hours after injection in patients with poor renal function?

<p>99mTc-DMSA (A)</p> Signup and view all the answers

What is the primary advantage of using 99mTc-glucoheptonate over 99mTc-DMSA for renal imaging?

<p>It allows for the assessment of renal perfusion and evaluation of the renal collecting systems and ureters. (D)</p> Signup and view all the answers

Which of the following statements about the glomerulus is true?

<p>It acts as a semipermeable membrane, allowing only small molecules to pass through. (C)</p> Signup and view all the answers

What is the typical adult administered activity of 99mTc-glucoheptonate for renal evaluation?

<p>8 mCi (296 MBq) (B)</p> Signup and view all the answers

What is the main purpose of diuretic renography?

<p>To distinguish obstructive from nonobstructive conditions (C)</p> Signup and view all the answers

Why is 99mTc-MAG3 preferred over 99mTc-DTPA in renography?

<p>It excretes primarily by tubular secretion (B)</p> Signup and view all the answers

What characterizes a classic acute or sub-acute high-grade obstructive renogram curve?

<p>Steeply rising continuous arched curve with well-defined excretion downsloping (B)</p> Signup and view all the answers

In patients with nonobstructive hydronephrosis, which part of the urinary system might not reach sufficient pressures during imaging?

<p>Ureteropelvic junction (B)</p> Signup and view all the answers

What type of activity curve is expected in post-diuretic renography for a patient with functional obstruction?

<p>Continuous rising curve (D)</p> Signup and view all the answers

What does the peak aortic activity represent in renography?

<p>Renal blood flow during the first minute (C)</p> Signup and view all the answers

What radiopharmaceutical is the agent of choice for renography in suspected obstructive hydronephrosis?

<p>^99^mTc-MAG3 (D)</p> Signup and view all the answers

What is the main benefit of using diuretic renography?

<p>Measuring ureteral pressure (A)</p> Signup and view all the answers

Which imaging technique is used to distinguish obstructive collecting system dilatation from nonobstructive hydronephrosis?

<p>^99^mTc-MAG3 scan (B)</p> Signup and view all the answers

What is the normal 20-minute maximal cortical ratio for 99mTc-MAG3?

<p>0.19 (A)</p> Signup and view all the answers

Which radiopharmaceutical is primarily used for the calculation of PAH clearance and ERPF?

<p>99mTc-MAG3 (D)</p> Signup and view all the answers

How is the GFR defined using radiopharmaceutical analogs?

<p>By the clearance of insulin (D)</p> Signup and view all the answers

What is used to estimate ERPF for tubular agents like 99mTc-MAG3?

<p>Single, timed blood sample obtained about 45 minutes after injection (D)</p> Signup and view all the answers

Which method of determining GFR and ERPF involves plasma sample-based clearances?

<p>Plasma sample-based clearances (D)</p> Signup and view all the answers

Why are camera-based clearances not as accurate as plasma sample-based clearances?

<p>Because they don't use blood or urine samples (A)</p> Signup and view all the answers

Which radiopharmaceutical is used for insulin clearance and GFR estimation?

<p>^99mTc-DTPA (B)</p> Signup and view all the answers

What role do computer-derived clearance values play in camera-based clearances?

<p>They simplify corrections for patient and acquisition variables (C)</p> Signup and view all the answers

'Effective' in the term 'effective renal plasma flow' means what?

<p>Different from PAH clearance (D)</p> Signup and view all the answers

How is MAG3 clearance expressed as a renal functional measurement?

<p>Through both single plasma sample-based and camera-based techniques (D)</p> Signup and view all the answers

Which of the following imaging techniques is primarily used for evaluating space-occupying lesions, functioning pseudotumors, or edema/scarring associated with acute or chronic pyelonephritis in the renal cortex?

<p>Renal cortical imaging with 99mTc-DMSA or glucoheptonate (B)</p> Signup and view all the answers

In patients with acute tubular necrosis (ATN), what pattern is typically observed on a renogram with 99mTc-MAG3?

<p>Bilateral persistent nephrograms with rising renogram curves (B)</p> Signup and view all the answers

Which of the following statements regarding acute renal vein thrombosis is true?

<p>There is decreased or absent perfusion and delayed, diminished accumulation and excretion of 99mTc-MAG3 (D)</p> Signup and view all the answers

What is the primary advantage of radionuclide imaging techniques over structural imaging methods like ultrasonography in evaluating urinary tract obstruction?

<p>Radionuclide imaging can depict urodynamics and functional information (A)</p> Signup and view all the answers

In cases of acute high-grade urinary tract obstruction, what pattern is typically observed on a routine radionuclide renogram?

<p>A rising renogram curve with persistent nephrogram (B)</p> Signup and view all the answers

Which of the following imaging modalities is considered the procedure of choice for evaluating renal artery occlusion, avulsion, or stenosis?

<p>Computed tomography (CT) (A)</p> Signup and view all the answers

In the evaluation of diffuse renal diseases like acute pyelonephritis or chronic glomerulonephritis, what is the typical finding on radionuclide imaging?

<p>Unilaterally or bilaterally poor vascular perfusion and poor radiopharmaceutical excretion (A)</p> Signup and view all the answers

Which of the following imaging findings in acute tubular necrosis (ATN) is associated with a favorable prognostic outcome?

<p>Reasonably good visualization of the kidneys (B)</p> Signup and view all the answers

What is the purpose of using a pinhole or high-resolution collimator, or single-photon emission computed tomography (SPECT) in renal cortical imaging?

<p>To improve spatial resolution and visualization of the renal cortex (B)</p> Signup and view all the answers

In the evaluation of acute pyelonephritis, what is the typical finding on a posterior perfusion image obtained after intravenous administration of technetium-99m mertiatide?

<p>Decreased perfusion to the affected kidney (B)</p> Signup and view all the answers

Which of the following statements about the glomerular filtration rate (GFR) and DTPA is correct?

<p>The normal GFR is 125 mL/min, and DTPA tends to underestimate the GFR slightly due to 5-10% protein binding. (D)</p> Signup and view all the answers

What is the primary mechanism of clearance for the radiopharmaceutical agent MAG3 (mercaptoacetyltriglycine)?

<p>Tubular secretion (&gt;95%) (A)</p> Signup and view all the answers

Which of the following statements about the extraction fraction of DTPA and MAG3 is true?

<p>MAG3 has a higher extraction fraction than DTPA, allowing for better renal visualization. (C)</p> Signup and view all the answers

Which of the following statements about the typical administered activity for DTPA and MAG3 in adults is correct?

<p>For both DTPA and MAG3, the typical administered activity is 10 mCi (370 MBq) or less. (D)</p> Signup and view all the answers

Which of the following statements about the renal perfusion phase of functional renal imaging is correct?

<p>Renal perfusion is evaluated from the posterior projection for native kidneys and the anterior projection for transplant kidneys. (B)</p> Signup and view all the answers

Which of the following statements about the imaging agent used for the renal perfusion phase is correct?

<p>A small bolus of high-activity (10 mCi [370 MBq]) 99mTc-labeled radiopharmaceutical (99mTc-DTPA or 99mTc-MAG3) is injected intravenously. (B)</p> Signup and view all the answers

Which of the following is a potential pitfall in interpreting the renal perfusion phase?

<p>The spleen may overlie the left kidney, giving a false impression of asymmetrically increased left renal perfusion or a 'phantom kidney' in patients with prior left nephrectomy. (B)</p> Signup and view all the answers

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