Radiation Techniques I Lecture 3: Indirect Ionization and Biological Damage
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Questions and Answers

What is the primary effect of radiation when it interacts with water?

  • Direct ionization of the target atoms
  • Excitation of the target atoms
  • Formation of toxic substances like H2O2
  • Production of hydrogen and hydroxyls (correct)

What is the main reason for the high probability of radiation interacting with the water in a cell?

  • Easy repair of single-strand breaks in the DNA
  • Small proportion of DNA in the cell
  • High volume of water in each cell (correct)
  • Low excitation energy required for water molecules

Which type of radiation-induced damage is more easily repaired with no long-term effect?

  • Production of toxic substances like H2O2
  • Single-strand breaks (SSB) (correct)
  • Indirect ionization of target atoms
  • Double-strand breaks (DSB)

What are the primary fragments produced when radiation breaks the chemical bonds of water?

<p>Hydrogen (H) and hydroxyls (OH) (D)</p> Signup and view all the answers

Which type of radiation-induced damage has more potential for long-term damage due to difficulty in repair?

<p>Double-strand breaks (DSB) (A)</p> Signup and view all the answers

What is the term for the loss of reproductive integrity in stem cells and other cells capable of many divisions due to radiation damage?

<p>Reproductive death (D)</p> Signup and view all the answers

What is the primary determinant of the response of tissue when it is irradiated?

<p>The dose in Rads (Gy) (A)</p> Signup and view all the answers

What happens when radiation enters a cell and the damage is not repaired, but the cell replicates itself in the damaged form?

<p>The cell undergoes reproductive death (B)</p> Signup and view all the answers

Which late effect of radiation includes fibrosis and other reactions mediated by vascular deficiencies?

<p>Delayed tissue reactions (D)</p> Signup and view all the answers

What is the term for potentially lethal damage that can be manipulated by repair when cells are allowed to remain in a non-dividing state?

<p>Sublethal damage (D)</p> Signup and view all the answers

What is the potential consequence of radiation interacting with water, leading to the formation of toxic substances like (H2 O2)?

<p>Cell destruction (D)</p> Signup and view all the answers

In a cell exposed to radiation, why is the probability of the radiation interacting with DNA molecules very small?

<p>DNA molecules are a small part of the cell's volume (D)</p> Signup and view all the answers

What is the primary effect of single-strand breaks (SSB) caused by radiation?

<p>No long-term effect with easy repair (A)</p> Signup and view all the answers

Why is the interaction of radiation with water more likely than with DNA molecules in a cell?

<p>Water makes up most of the cell's volume (C)</p> Signup and view all the answers

What is the potential consequence of radiation interacting with double-strand breaks (DSB)?

<p>Long-term damage with difficulty in repair (A)</p> Signup and view all the answers

What is the term for radiation damage that is irreversible, irreparable, and leads to cell death?

<p>Lethal damage (A)</p> Signup and view all the answers

Which type of radiation-induced damage can be repaired in hours unless additional sublethal damage is added that eventually leads to lethal damage?

<p>Sublethal damage (D)</p> Signup and view all the answers

What are the primary late effects of radiation?

<p>Life span shortening (D)</p> Signup and view all the answers

Which type of radiation-induced damage can be manipulated by repair when cells are allowed to remain in a non-dividing state?

<p>Potentially lethal damage (D)</p> Signup and view all the answers

Which late effect of radiation includes reactions mediated by vascular deficiencies?

<p>Delayed tissue reactions (D)</p> Signup and view all the answers

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