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Questions and Answers
What is the primary route of transmission of the rabies virus from an infected animal?
What is the characteristic cellular finding in rabies encephalitis?
What is the primary organ system affected by the rabies virus during transmission?
What is a potential non-bite transmission route of rabies?
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What is the duration of the incubation period of rabies?
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How does the rabies virus travel from the site of infection to the central nervous system?
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What is the primary mechanism of rabies virus multiplication in the central nervous system?
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What is a potential consequence of rabies virus transmission to the salivary glands?
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What is the primary target of rabies post-exposure prophylaxis?
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What is a characteristic feature of the rabies virus structure?
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Study Notes
Rabies Virus Characteristics
- Bullet shape, negative-sense ssRNA, helical, enveloped with surface spikes
Infection and Transmission
- Infected cells contain inclusion bodies (Negri bodies)
- Infects animals and is present in saliva, affecting the Central Nervous System (CNS)
- Can be transmitted through:
- Bite of an infected animal (virus in saliva)
- Non-bite transmission (e.g. inhalation of aerosols in bat-infected caves, corneal transplantation)
Pathogenesis
- Virus travels from wound to brain via peripheral nerves (no viremia)
- Multiplies in CNS, forming Negri bodies in affected cells (intracytoplasmic)
- Spreads via peripheral nerves to salivary glands, eventually reaching saliva
Incubation Period
- Lasts from 2 weeks to 16 weeks or longer, depending on various factors
Viral Forms
- One antigenic type, two biological forms:
- Street virus (wild, found in nature)
- Fixed virus (prepared in laboratory for vaccine preparation)
Clinical Picture
- Encephalitis, which progresses through three stages
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Description
This quiz covers the biological characteristics of the Rabies virus, including its shape, genetic material, and effects on infected cells and animals. It also covers the different forms of the virus and their uses.
