Quinolones

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Questions and Answers

Which generation of quinolones has a basic piperazino group at C-7 and a fluorine atom at C-6?

  • Second generation (correct)
  • First generation
  • Fourth generation
  • Third generation

What is the main characteristic of the first generation quinolones?

  • Narrow spectrum (Gram-negative bacteria) (correct)
  • Broad spectrum (Gram-negative and Gram-positive bacteria)
  • Long-lasting pharmacokinetic properties
  • Effective against complicated urinary tract infections

Which ring is common to all quinolones?

  • N1-alkylated-3-carboxypyrid-4-one ring (correct)
  • N1-alkylated-3-carboxypyrid-5-one ring
  • N1-alkylated-3-carboxypyrid-6-one ring
  • N1-alkylated-3-carboxypyrid-2-one ring

What is the therapeutic use of the first generation quinolones?

<p>Treatment of uncomplicated urinary tract infections (A)</p> Signup and view all the answers

Which generation of quinolones has a wider spectrum of action, including Gram-negative bacteria and Staphylococci?

<p>Second generation (A)</p> Signup and view all the answers

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Study Notes

Quinolones

  • The second generation of quinolones has a basic piperazino group at C-7 and a fluorine atom at C-6.
  • The main characteristic of the first generation quinolones is the narrow spectrum of antibacterial activity.
  • The 4-quinolone ring is common to all quinolones.
  • The first generation quinolones are used to treat urinary tract infections (UTIs) and other Gram-negative bacterial infections.
  • The second generation of quinolones has a wider spectrum of action, including Gram-negative bacteria and Staphylococci.

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