Questions and Answers
What is the trade name of Quetiapine?
What classification does Quetiapine fall under?
Antipsychotic
What is the FDA category of Quetiapine?
C
How is Quetiapine metabolized?
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What are the primary actions and uses of Quetiapine?
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What are some side effects of Quetiapine?
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Which of the following can interact with Quetiapine? (Select all that apply)
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What is the initial dosing for schizophrenia using immediate release tablets?
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What should nursing considerations include when administering Quetiapine?
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What should patients be taught regarding the use of extended-release Quetiapine tablets?
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What labs should be checked while on Quetiapine?
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Study Notes
Quetiapine Overview
- Generic name: Quetiapine; Trade name: Seroquel
- Classified as an antipsychotic medication
- FDA Category: C, indicating potential risks in pregnancy
Pharmacologic Properties
- Well absorbed after oral administration
- Undergoes significant hepatic metabolism primarily via CYP3A4
- Excreted in urine and feces with a half-life of about six hours
Actions and Uses
- SGA indicated for treating schizophrenia, major depression, and acute mania/depression in bipolar disorder
- Improves both positive and negative symptoms of schizophrenia, enhancing cognitive function
- Strongly blocks 5-HT2 receptors; has a weaker blockade of D2 receptors
Side Effects
- Risk of prolonged QT interval
- Common side effects include sedation, orthostatic hypotension, dizziness, dry mouth, hyperglycemia, and sweating
- Moderate potential for metabolic adverse effects like weight gain, diabetes, and dyslipidemia
Drug Interactions
- Caution with alcohol, anticholinergics, antihypertensives, carbamazepine, CNS depressants, dopamine antagonists, glucocorticoids, and drugs that prolong QT interval
Dosing Information
- Schizophrenia: Start immediate release at 25 mg twice daily, titrating to 400-800 mg; Extended release begins at 300 mg once daily, also titrating to 400-800 mg
- Major depression: Dosage ranges from 150 to 300 mg once daily using the extended-release formulation
Nursing Considerations
- Exercise caution in elderly patients or those with renal or hepatic impairments
- Monitor patients for signs of hyperglycemia and ensure proper hydration, especially in older adults
- Not recommended for use during pregnancy
Patient Teaching
- Instruct patients to swallow extended-release tablets whole; do not chew, crush, or cut
- Advise to avoid alcohol consumption
- Educate on safety precautions regarding CNS effects and to report symptoms like fever, unusual bleeding, rash, and any suicidal thoughts
Laboratory Monitoring
- Regularly check kidney and liver function tests to monitor for potential adverse effects
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Description
Test your knowledge on Quetiapine, an antipsychotic medication. This quiz includes its classification, FDA category, pharmacologic properties, and more. Perfect for students or professionals looking to refresh their understanding of this drug.
