Podcast
Questions and Answers
What is the potential problem of selecting a study site that is underperforming for an experimental condition?
What is the potential problem of selecting a study site that is underperforming for an experimental condition?
Which of the following is NOT a mitigation strategy for addressing potential weaknesses in quasi-experimental designs?
Which of the following is NOT a mitigation strategy for addressing potential weaknesses in quasi-experimental designs?
What is the primary concern with collecting data from sufficient time points across all sites?
What is the primary concern with collecting data from sufficient time points across all sites?
Which type of design utilizes staggered implementation of the intervention across all participants?
Which type of design utilizes staggered implementation of the intervention across all participants?
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How can qualitative methods contribute to mitigating weaknesses in quasi-experimental designs?
How can qualitative methods contribute to mitigating weaknesses in quasi-experimental designs?
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What is the main limitation of propensity score weighting as a mitigation strategy?
What is the main limitation of propensity score weighting as a mitigation strategy?
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Which of the following is a potential ethical concern with using a quasi-experimental design?
Which of the following is a potential ethical concern with using a quasi-experimental design?
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Why is it important to select a control group that is as similar as possible to the intervention site(s) in a quasi-experimental design?
Why is it important to select a control group that is as similar as possible to the intervention site(s) in a quasi-experimental design?
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What type of study design is highlighted by Betran et al. for improving antenatal care in Mozambique?
What type of study design is highlighted by Betran et al. for improving antenatal care in Mozambique?
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Which of the following is a primary focus of the collaborative care model described by Bodenheimer et al.?
Which of the following is a primary focus of the collaborative care model described by Bodenheimer et al.?
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What aspect does the adaptive implementation strategy aim to improve according to Kilbourne et al.?
What aspect does the adaptive implementation strategy aim to improve according to Kilbourne et al.?
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Which publication discusses adaptive designs specifically for clinical trials?
Which publication discusses adaptive designs specifically for clinical trials?
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In the systematic review by Brown and Lilford, which trial design is evaluated?
In the systematic review by Brown and Lilford, which trial design is evaluated?
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What is one of the key goals described in the study by Kilbourne et al. for improving outcomes for persons with serious mental illness?
What is one of the key goals described in the study by Kilbourne et al. for improving outcomes for persons with serious mental illness?
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Which of the following is NOT a focus in improving primary care as highlighted by Bodenheimer et al.?
Which of the following is NOT a focus in improving primary care as highlighted by Bodenheimer et al.?
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Which aspect of healthcare delivery was specifically mentioned in the study by Merialdi et al.?
Which aspect of healthcare delivery was specifically mentioned in the study by Merialdi et al.?
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What is a key feature of stepped wedge designs in implementation science?
What is a key feature of stepped wedge designs in implementation science?
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What is the primary purpose of using experimental designs in implementation science?
What is the primary purpose of using experimental designs in implementation science?
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Which of the following is considered the gold standard for testing treatment efficacy in clinical trials?
Which of the following is considered the gold standard for testing treatment efficacy in clinical trials?
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What type of experimental design does NOT require random assignment of subjects?
What type of experimental design does NOT require random assignment of subjects?
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What is a common characteristic of implementation-oriented randomized controlled trials (RCTs)?
What is a common characteristic of implementation-oriented randomized controlled trials (RCTs)?
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What is one of the main strengths of experimental designs in implementation studies?
What is one of the main strengths of experimental designs in implementation studies?
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Which methodological approach is likely to be used to address specific implementation science questions?
Which methodological approach is likely to be used to address specific implementation science questions?
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What does interrupted time series (ITS) design primarily focus on?
What does interrupted time series (ITS) design primarily focus on?
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Which study design implements adaptive randomization for quality improvement in depression treatment programs?
Which study design implements adaptive randomization for quality improvement in depression treatment programs?
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What is the primary goal of the multiphase optimization strategy (MOST)?
What is the primary goal of the multiphase optimization strategy (MOST)?
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Which factor is crucial for implementing evidence-based interventions in health care according to the replicating effective programs framework?
Which factor is crucial for implementing evidence-based interventions in health care according to the replicating effective programs framework?
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The application of factorial experiments in intervention evaluation helps in assessing what?
The application of factorial experiments in intervention evaluation helps in assessing what?
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In what context was a randomized controlled trial applied among individuals with bipolar disorder?
In what context was a randomized controlled trial applied among individuals with bipolar disorder?
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Which of the following authors contributed to the design of experiments with multiple independent variables?
Which of the following authors contributed to the design of experiments with multiple independent variables?
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What is a significant advantage of using sequential multiple assignment randomized trials (SMART)?
What is a significant advantage of using sequential multiple assignment randomized trials (SMART)?
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Which approach emphasizes partnerships between academic and public entities for evidence-based implementation?
Which approach emphasizes partnerships between academic and public entities for evidence-based implementation?
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What is the main focus of the research conducted by Kirchner et al. in 2014?
What is the main focus of the research conducted by Kirchner et al. in 2014?
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Which design is used to build individualized treatment sequences as discussed by Lei et al.?
Which design is used to build individualized treatment sequences as discussed by Lei et al.?
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In the 2019 study by Lew et al., what is a notable method employed to reduce imbalance in implementation trials?
In the 2019 study by Lew et al., what is a notable method employed to reduce imbalance in implementation trials?
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What aspect of treatment does Nahum-Shani et al. highlight in their 2012 research?
What aspect of treatment does Nahum-Shani et al. highlight in their 2012 research?
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What was the approach of the study conducted by Morgan in 2018 regarding the bias in randomized controlled trials?
What was the approach of the study conducted by Morgan in 2018 regarding the bias in randomized controlled trials?
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Cousins et al. studied the impact of which specific intervention in university populations?
Cousins et al. studied the impact of which specific intervention in university populations?
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What key concept is described in the work of Curran et al. that combines elements of different research types?
What key concept is described in the work of Curran et al. that combines elements of different research types?
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What primary focus did Morton and Torgerson address in their 2003 study?
What primary focus did Morton and Torgerson address in their 2003 study?
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What distinguishes implementation RCTs from traditional clinical trials?
What distinguishes implementation RCTs from traditional clinical trials?
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Which design is particularly suited for addressing ongoing needs in implementation strategies?
Which design is particularly suited for addressing ongoing needs in implementation strategies?
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What is a common outcome measure focused on in implementation RCTs?
What is a common outcome measure focused on in implementation RCTs?
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How do factorial designs aid in implementation science?
How do factorial designs aid in implementation science?
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What is the primary focus when utilizing single subject experimental designs (SSEDs)?
What is the primary focus when utilizing single subject experimental designs (SSEDs)?
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Which of the following statements about implementation RCTs is false?
Which of the following statements about implementation RCTs is false?
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What is the role of outcome measures in SMART designs?
What is the role of outcome measures in SMART designs?
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What is a key purpose of using multi-component implementation strategies?
What is a key purpose of using multi-component implementation strategies?
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Flashcards
Randomized Controlled Trial (RCT)
Randomized Controlled Trial (RCT)
An experimental study design that randomly assigns participants to treatment or control groups to test efficacy.
Implementation Science
Implementation Science
The study of methods to promote the uptake of research findings into routine practice.
Quasi-Experimental Designs
Quasi-Experimental Designs
Study designs that lack random assignment but aim to evaluate interventions.
Stepped Wedge Design
Stepped Wedge Design
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Pre-Post Design
Pre-Post Design
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Interrupted Time Series (ITS)
Interrupted Time Series (ITS)
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Strengths and Weaknesses of Designs
Strengths and Weaknesses of Designs
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Citrus Fruit and Scurvy
Citrus Fruit and Scurvy
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Implementation Research
Implementation Research
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Factorial Design
Factorial Design
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Single Subject Experimental Design (SSED)
Single Subject Experimental Design (SSED)
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RCT vs. Implementation RCT
RCT vs. Implementation RCT
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SMART Trials
SMART Trials
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Outcome Measures in Implementation RCTs
Outcome Measures in Implementation RCTs
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Multi-Component Strategies
Multi-Component Strategies
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Evaluation of Implementation Strategies
Evaluation of Implementation Strategies
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Regression to the Mean
Regression to the Mean
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Type I Error
Type I Error
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Control Group Matching
Control Group Matching
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Propensity Score Weighting
Propensity Score Weighting
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Time Points Collection
Time Points Collection
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Stepped Wedge Trials
Stepped Wedge Trials
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Qualitative Methods in Research
Qualitative Methods in Research
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Confounding Effects
Confounding Effects
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Single-Subject Experimental Design
Single-Subject Experimental Design
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Sequential Multiple Assignment Randomized Trial (SMART)
Sequential Multiple Assignment Randomized Trial (SMART)
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Multiphase Optimization Strategy (MOST)
Multiphase Optimization Strategy (MOST)
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Factorial Experiment
Factorial Experiment
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Evidence-Based Practice
Evidence-Based Practice
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Implementation Strategies
Implementation Strategies
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Collaborative Care Attendance
Collaborative Care Attendance
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Public-Academic Partnerships
Public-Academic Partnerships
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Adaptive Implementation Strategy
Adaptive Implementation Strategy
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Behavioral Dynamic Treatment
Behavioral Dynamic Treatment
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SMART Design
SMART Design
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Cluster Randomized Trial
Cluster Randomized Trial
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Robust Methods in RCTs
Robust Methods in RCTs
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Stepped-Wedge Cluster Randomized Trial
Stepped-Wedge Cluster Randomized Trial
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Quality of Antenatal Care
Quality of Antenatal Care
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Screening for Alcohol Use
Screening for Alcohol Use
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Collaborative Care Model
Collaborative Care Model
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Campus Watch Intervention
Campus Watch Intervention
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Chronic Care Model
Chronic Care Model
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Hybrid Designs in Research
Hybrid Designs in Research
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Life Goals in Mental Health
Life Goals in Mental Health
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Experimental Design in Interventions
Experimental Design in Interventions
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Medical Supply Kits
Medical Supply Kits
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Study Notes
Experimental and Quasi-Experimental Designs in Implementation Research
- Implementation science aims to improve clinical practice adoption, use, and sustainability.
- Randomized controlled trials (RCTs) are often used in implementation science.
- Implementation-focused RCTs differ from traditional RCTs in their focus on implementation strategies rather than treatment efficacy.
- Implementation RCTs often use cluster randomization (e.g., sites or clinics) due to potential contamination.
- Quasi-experimental designs are used when randomization is inappropriate, estimating intervention effects without randomization.
Experimental Designs (e.g., RCTs)
- Key distinction: manipulation of an independent variable and random assignment of subjects.
- Implementation-focused RCTs often focus on implementation strategies, not just treatment efficacy.
- Outcome measures often include implementation success (e.g., number of patients treated, providers employing the treatment in appropriate manner).
- Cluster randomization is common to minimize contamination between groups and ensure similar groups.
- Optimization trials are used to determine the best implementation strategies, whom to target, and timings, often involving comparative strategies.
- Factorial and fractional-factorial designs are used with multi-component strategies as they randomize participants to different combinations of implementation strategies and evaluate strategies individually.
- Sequential Multiple Assignment Randomized Trials (SMARTs) use information from participants' treatment response data to optimize sequences through adaptive allocation procedures.
- Single Subject Experimental Designs (SSEDs), including ABA designs, may be used when analyzing a single subject or group, aiming to observe changes over time.
Quasi-Experimental Designs
- These designs are used to estimate intervention effects without randomization.
- Pre-post with non-equivalent control group: compares changes between an intervention and control group over time. Measures pre- and post-intervention data, identifying group differences. Crucial to select comparable control and intervention groups.
- Interrupted time series (ITS): studies changes in outcome over time, before and after an intervention, leveraging repeated data collection. Analyses assess whether the intervention is associated with a change in pre-existing trends. Needs sufficient data points before and after the intervention to identify true effect.
- Stepped wedge designs: all participants receive the intervention eventually but in staggered time intervals, creating staggered control/intervention periods. The intervention group at later phases serves as a control for earlier intervention phases and helps address resource limitations.
Methodology
- Adaptive Trial Designs: Adaptive trial designs offer potential for modifying treatment allocations, sample sizes or recruitment methods based on observed data during the trial, increasing flexibility and efficacy.
- Data collection timing: Timing of data collections is crucial for interpreting the findings accurately.
Additional Points
- Many of the methods described are also applicable to general healthcare research in various contexts.
- Ethical considerations regarding treatment allocation sequences are crucial.
Studying That Suits You
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Description
Test your knowledge on quasi-experimental designs with this quiz. Explore potential problems, limitations, and ethical concerns in designing such studies. Dive into strategies to mitigate weaknesses and the role of qualitative methods.