Podcast
Questions and Answers
What was the aim of the study mentioned in the text?
What was the aim of the study mentioned in the text?
To assess the efficacy and safety of LGG treatment in children with BA after HPE.
How was the trial conducted in the study?
How was the trial conducted in the study?
It was a double-blind placebo-controlled trial with patients randomized into treatment group receiving LGG and placebo.
What was the main finding related to short-chain fatty acids (SCFA) in children with BA?
What was the main finding related to short-chain fatty acids (SCFA) in children with BA?
There were lower concentrations of SCFA in children with BA compared to the control group.
What change was observed in the number of Enterococcus bacteria after treatment?
What change was observed in the number of Enterococcus bacteria after treatment?
How did the laboratory parameters and gut microbiota composition differ between the LGG group and the placebo group after treatment?
How did the laboratory parameters and gut microbiota composition differ between the LGG group and the placebo group after treatment?
What was the difference in the occurrence of bacterial cholangitis between the LGG group and the placebo group?
What was the difference in the occurrence of bacterial cholangitis between the LGG group and the placebo group?
At what age did the infants undergo Kasai surgery?
At what age did the infants undergo Kasai surgery?
What was the placebo group given instead of LGG?
What was the placebo group given instead of LGG?
How long was the active compound LGG (6 £ 109 CFU) given to the children?
How long was the active compound LGG (6 £ 109 CFU) given to the children?
How many children were in the treatment group that received LGG added to milk formula?
How many children were in the treatment group that received LGG added to milk formula?
When was the first dose of study medication given to the patients?
When was the first dose of study medication given to the patients?
Who prepared and provided the capsules with study medication?
Who prepared and provided the capsules with study medication?
What is the aim of the study mentioned in the text?
What is the aim of the study mentioned in the text?
What is the treatment of choice for biliary atresia?
What is the treatment of choice for biliary atresia?
What is postulated to be implicated in the interplay between progressive liver injury and gut microbiota?
What is postulated to be implicated in the interplay between progressive liver injury and gut microbiota?
What is the major early complication after the Kasai operation?
What is the major early complication after the Kasai operation?
What is the cause of bacterial cholangitis post-surgery?
What is the cause of bacterial cholangitis post-surgery?
What is characterized by progressive fibrosis of intra- and extrahepatic bile ducts?
What is characterized by progressive fibrosis of intra- and extrahepatic bile ducts?
What percentage of patients in the historical control group developed BCH?
What percentage of patients in the historical control group developed BCH?
How many episodes of BCH did the LGG group have after Kasai operation?
How many episodes of BCH did the LGG group have after Kasai operation?
What was the prevalence of Enterococci species in culture-proven cholangitis in the study?
What was the prevalence of Enterococci species in culture-proven cholangitis in the study?
What was the rate of BCH development in the study compared to previously reported series?
What was the rate of BCH development in the study compared to previously reported series?
What was the effect of L casei rhamnosus according to the study by Lien et al.?
What was the effect of L casei rhamnosus according to the study by Lien et al.?
What percentage of patients developed BCH in each of the randomized groups in the study by Lien et al.?
What percentage of patients developed BCH in each of the randomized groups in the study by Lien et al.?
What method was used to quantify Clostridium strains in the fecal samples?
What method was used to quantify Clostridium strains in the fecal samples?
In what type of medium were Bacteroides Schaedler quantified?
In what type of medium were Bacteroides Schaedler quantified?
How were Bifidobacterium strains quantified in the fecal samples?
How were Bifidobacterium strains quantified in the fecal samples?
Which medium was used to determine Lactobacillus content in the samples?
Which medium was used to determine Lactobacillus content in the samples?
Under what conditions were the cultures incubated for the determination of Clostridium, Bifidobacterium, and Bacteroides?
Under what conditions were the cultures incubated for the determination of Clostridium, Bifidobacterium, and Bacteroides?
What method was used to analyze the content of short-chain fatty acids (SCFA) in the study?
What method was used to analyze the content of short-chain fatty acids (SCFA) in the study?
