Pulmonary Volumes and Capacities Quiz

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Questions and Answers

What primarily causes most damage during ARDS?

  • IL-10
  • IL-1
  • TNFa (correct)
  • IL-6

What is a major consequence of decreased presence of surfactants in ARDS?

  • Enhanced lung volume
  • Increased alveolar compliance
  • Improved gas exchange
  • Atelectasis (correct)

Which of the following is a symptom of ARDS?

  • Formation of hyaline membranes (correct)
  • Enhanced type II pneumocyte function
  • Decreased fibrosis of alveolar walls
  • Increased total lung volume

Which cellular process is involved in the fibrotic response seen in ARDS?

<p>Unregulated growth of fibroblasts (B)</p> Signup and view all the answers

What is a direct effect of the liquefaction necrosis seen in ARDS?

<p>Release of lytic enzymes (C)</p> Signup and view all the answers

What is the primarily reduced measurement in cases of emphysema, pneumonia, and pulmonary edema when assessing lung function?

<p>Diffusing capacity of lung carbon monoxide (DLCO) (A)</p> Signup and view all the answers

Which component contributes to the calculation of Functional Residual Capacity (FRC)?

<p>Expiratory reserve volume (C), Residual volume (D)</p> Signup and view all the answers

Which pulmonary capacity is defined as the maximum amount of air expirable after the lungs are filled to maximum extent?

<p>Vital Capacity (VC) (B)</p> Signup and view all the answers

What happens to the Total Lung Capacity (TLC) in restrictive disorders?

<p>It is reduced (C)</p> Signup and view all the answers

What is the average Vital Capacity (VC) for women?

<p>3500 mL (B)</p> Signup and view all the answers

Which of the following processes is NOT involved in pulmonary function?

<p>Hormonal regulation of glucose (C)</p> Signup and view all the answers

When is Functional Residual Capacity (FRC) typically increased?

<p>In obstructive disorders (C)</p> Signup and view all the answers

Which measurement indicates both respiratory muscle strength and ventilatory reserve?

<p>Forced Vital Capacity (FVC) (A)</p> Signup and view all the answers

What is the role of ventilation in the respiratory system?

<p>Circulation of atmospheric air for gas exchange (A)</p> Signup and view all the answers

Why is it easier for foreign objects to be aspirated into the right bronchus?

<p>It is shorter and more vertical (C)</p> Signup and view all the answers

What primarily affects airway resistance in the respiratory system?

<p>Airway length and radius (A)</p> Signup and view all the answers

According to Boyle's Law, how does the volume of gas change in relation to pressure?

<p>Volume decreases as pressure increases (D)</p> Signup and view all the answers

What is an example of an anatomic dead space in the respiratory system?

<p>Conducting airways beyond the larynx (A)</p> Signup and view all the answers

What is the primary purpose of goblet cells in the respiratory system?

<p>To produce mucus (B)</p> Signup and view all the answers

What occurs during inhalation according to the principles of pressure in the lungs?

<p>Atmospheric air pressure exceeds intrathoracic pressure (B)</p> Signup and view all the answers

What defines physiologic dead space in the respiratory system?

<p>All areas where gas diffusion is ineffective, including anatomic dead space (B)</p> Signup and view all the answers

What is the primary purpose of bile in digestion?

<p>To emulsify large fat particles into minute particles. (D)</p> Signup and view all the answers

Which type of carcinoma is generally considered more responsive to treatment?

<p>Adenocarcinoma (B), Squamous Cell Carcinoma (D)</p> Signup and view all the answers

What is a characteristic feature of malignant cells?

<p>High nuclear/cytoplasmic ratio (B)</p> Signup and view all the answers

Which cells secrete bile acids and other components into bile canaliculi?

<p>Hepatocytes. (A)</p> Signup and view all the answers

What environmental factor is responsible for 85% of all lung cancer deaths?

<p>Cigarette smoking (A)</p> Signup and view all the answers

How does the gallbladder contribute to bile concentration?

<p>By absorbing water and electrolytes. (A)</p> Signup and view all the answers

Which symptom is NOT commonly associated with lung cancer?

<p>Frequent headache (B)</p> Signup and view all the answers

What stimulates gallbladder emptying after a meal?

<p>Presence of fatty foods in the duodenum. (C)</p> Signup and view all the answers

Which enzyme is primarily involved in the digestion of fats?

<p>Pancreatic lipase. (A)</p> Signup and view all the answers

Which is a known carcinogen that can contribute to lung cancer development?

<p>Beryllium (B)</p> Signup and view all the answers

What is the primary function of the gastrointestinal (GI) tract?

<p>Digestion and absorption (D)</p> Signup and view all the answers

What factor can lead to the development of gallstones?

<p>Excessive absorption of water or cholesterol. (D)</p> Signup and view all the answers

What is indicated by a high level of environmental carcinogens in an individual?

<p>Prolonged exposure increases cancer risk (D)</p> Signup and view all the answers

Which structure is not involved in the secretion of bile?

<p>Spleen. (D)</p> Signup and view all the answers

What defines the process of malignant transformation in cells?

<p>Unregulated cell division (A)</p> Signup and view all the answers

What effect do enterogastric reflexes have on stomach emptying?

<p>They inhibit stomach emptying. (C)</p> Signup and view all the answers

What primarily initiates the inhibition of the pyloric pump contractions?

<p>Osmolarity of duodenal chyme (A)</p> Signup and view all the answers

Which process moves chyme through the digestive tract at a very slow pace?

<p>Peristalsis (A)</p> Signup and view all the answers

What is the primary role of Brunner's glands located in the duodenum?

<p>Secretion of alkaline mucus (D)</p> Signup and view all the answers

Which statement correctly describes the action of segmentation in the small intestine?

<p>It mixes chyme through localized concentric contractions. (C)</p> Signup and view all the answers

What is the main consequence of sympathetic stimulation on Brunner's glands?

<p>Decreased secretion of alkaline mucus (D)</p> Signup and view all the answers

What role do goblet cells play in the intestinal lining?

<p>Produce mucus for lubrication (D)</p> Signup and view all the answers

How long does it take for chyme to travel from the pylorus to the ileocecal valve?

<p>3-5 hours (D)</p> Signup and view all the answers

Which of the following factors does NOT lead to the secretion of secretin from the duodenum?

<p>Presence of fats (C)</p> Signup and view all the answers

Flashcards

DLCO (Diffusing Capacity of Lung Carbon Monoxide)

Measures how well gas moves from alveoli to erythrocytes in pulmonary circulation.

Inspiratory Capacity (IC)

Maximum air inspired, combining tidal volume and inspiratory reserve volume.

Functional Residual Capacity (FRC)

Air remaining in lungs after normal exhalation, comprising expiratory reserve volume and residual volume.

Vital Capacity (VC)

Maximum exhaled air after maximal inhalation, sum of IRV, TV, and ERV.

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Total Lung Capacity (TLC)

Maximum lung volume, including tidal volume, inspiratory & expiratory reserve volumes, and residual volume.

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Forced Vital Capacity (FVC)

Maximum exhaled air as fast as possible after maximal inhalation.

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Obstructive Pulmonary Disorders

Conditions impacting the flow of air out of lungs; FRC is often increased.

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Restrictive Pulmonary Disorders

Conditions limiting lung expansion; TLC is often reduced.

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ARDS Definition

Acute Respiratory Distress Syndrome (ARDS) is a serious lung condition causing fluid buildup in the lungs, hindering oxygen absorption.

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ARDS Cause

ARDS is usually preceded by another injury (like ALI) and is driven by the inflammatory response, especially a cytokine storm.

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ARDS Inflammation

The inflammatory process in ARDS causes the release of harmful substances, damaging lung tissues and interfering with gas exchange.

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ARDS Tissue Damage

ARDS damages both epithelial and endothelial cells in the lungs, leading to scarring and decreased lung compliance.

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Hyaline Membranes ARDS

Hyaline membranes formed in ARDS reduce gas exchange as they block air passage within the alveoli, impeding oxygen transfer.

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ARDS Surfactants

The loss of surfactant in ARDS reduces lung elasticity and makes breathing more difficult.

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ARDS Fibrosis

Extensive fibrosis in ARDS results in permanent lung damage, impairing lung function.

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ARDS Alveolar Volume

As alveolar volume decreases in ARDS it leads to lower amounts of air in the lungs.

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ARDS Atelectasis

Atelectasis is a collapse or closure of lung regions in ARDS, further compromising the ability to exchange gases.

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Pancreatic Lipase

A specific enzyme that helps digest fats within the pancreas.

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Centeroacinar Cells

Pancreatic cells that secrete bicarbonate to neutralize stomach acid.

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Bile Purpose

Breaks down large fat particles for easier digestion by pancreatic lipase; aids fat absorption.

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Bile Secretion

Constant secretion of bile acids, cholesterol, lecithin, and bilirubin by hepatocytes into bile canaliculi.

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Gallbladder Function

Stores and concentrates bile before releasing it into the small intestine.

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Gallstones

Formation of hard deposits in the gallbladder due to too much water absorption, bile acid or cholesterol.

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Stomach Emptying Regulation

Duodenum controls the rate of stomach emptying through inhibitory effects.

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Non-small cell lung cancer

A type of lung cancer that is more responsive to treatment than small cell lung cancer.

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Adenocarcinoma lung cancer

A specific type of non-small cell lung cancer.

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Squamous cell carcinoma (lung)

Another specific type of non-small cell lung cancer.

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Large cell carcinoma (lung)

A type of aggressive non-small cell lung cancer.

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Small cell lung cancer

A type of lung cancer less responsive to treatment.

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Malignant transformation

A change in a normal cell to a cancer cell.

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Environmental carcinogens

Substances that cause cancer.

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Cigarette smoking (lung cancer)

A major risk factor for lung cancer, associated with 85% of lung cancer deaths.

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GI tract

The entire digestive system from mouth to anus.

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Alimentary canal

The digestive tract, consisting of the organs involved in digestion.

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Digestion and absorption

The main functions of the gastrointestinal (GI) tract.

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Ventilation

Movement of air into and out of the lungs for gas exchange.

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Perfusion

Blood flow to tissues for gas exchange.

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Gas Diffusion

Movement of O2 and CO2 across membranes from high to low pressure.

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Right Bronchus

Shorter and more vertical than left, making aspiration easier.

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Alveoli

Tiny air sacs in lungs for gas exchange, about 500 million in adults.

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Dead Space

Areas of the airways where gas exchange doesn't occur.

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Anatomic Dead Space

Parts of the airways where gas diffusion does not occur; usually ~150 mL.

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Physiologic Dead Space

Anatomic dead space + areas where gas diffusion is compromised.

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Airway Resistance

The tendency of the airways to oppose airflow; affected by length, radius, and rate.

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Boyle's Law

Pressure and volume of a gas are inversely related (constant temperature and mass).

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Inhalation

Process when atmospheric air pressure is greater than intrathoracic.

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Exhalation

Process when intrathoracic pressure is greater than atmospheric.

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Duodenal Distension

The stretching of the duodenum, a part of the small intestine.

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Irritated Duodenal Mucosa

Inflammation or damage to the lining of the duodenum.

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Pyloric Pump

Muscle contractions in the pylorus (the stomach's exit), responsible for propelling food.

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Pyloric Sphincter

Ring of muscle that controls the passage of food from the stomach to the small intestine

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Ileocecal Valve

A valve preventing backflow from the large intestine to the small intestine.

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Mixing Contractions/Segmentation

Localized contractions that mix chyme (digested food) in the small intestine.

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Peristalsis

Propulsive waves of contraction that move food through the intestines.

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Brunner's Glands

Glands in the duodenum that produce alkaline mucus, neutralizing stomach acid.

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Goblet Cells

Cells in the small intestine that produce mucus to protect and lubricate.

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Enterocytes

Cells lining the small intestine responsible for absorbing nutrients.

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Study Notes

Pulmonary Volumes

  • Tidal Volume (TV): Volume of air inhaled and exhaled in a normal breath, approximately 500 mL.
  • Minute Tidal Volume: Total volume of air inhaled and exhaled per minute (TV x respiratory rate), approximately 8 L.
  • Alveolar Volume: Volume of air reaching the alveoli (Tidal Volume – dead space volume), approximately 350 mL. Average minute alveolar volume is 5600 mL.
  • Inspiratory Reserve Volume (IRV): Extra volume of air that can be inhaled beyond a normal breath, approximately 3000 mL. Indicates inspiratory muscle strength.
  • Expiratory Reserve Volume (ERV): Volume of air that can be forcefully exhaled after a normal breath, approximately 1100 mL. Indicates expiratory muscle strength.
  • Residual Volume (RV): Volume of air remaining in lungs after a forceful exhalation, approximately 1200 mL. Indicates airway patency & elasticity.

Pulmonary Capacities

  • Inspiratory Capacity (IC): Maximum amount of air that can be inspired (TV + IRV), approximately 3500 mL.
  • Functional Residual Capacity (FRC): Amount of air remaining in the lungs at the end of a normal breath (ERV + RV), approximately 2300 mL. Increased in obstructive disorders.
  • Vital Capacity (VC): Maximum amount of air that can be expelled from the lungs after maximum inhalation (IRV + TV + ERV), approximately 4600 mL.
  • Total Lung Capacity (TLC): Maximum volume lungs can hold (TV + IRV + ERV + RV), approximately 6 L. Reduced in restrictive disorders, increased in severe COPD.
  • Forced Vital Capacity (FVC): Maximum amount of air that can be exhaled as quickly as possible, indicates respiratory muscle strength and ventilatory reserve. Average for men is 4800 mL, women is 3500 mL. Reduced in obstructive and restrictive diseases.

Pulmonary Functions

  • Ventilation: Movement of air into and out of the lungs.
  • Perfusion: Circulation of blood through the lungs.
  • Diffusion: Movement of oxygen and carbon dioxide across the alveolocapillary membrane.
  • Regulation of oxygenation and gas exchange
  • Protection (macrophages, surfactant)
  • Maintenance of cardiac output and blood pressure
  • Immunity
  • Fluid, electrolyte, and acid-base balance

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