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Questions and Answers
What will likely result from a lesion in the anterior hypothalamus?
What will likely result from a lesion in the anterior hypothalamus?
- Diabetes insipidus
- Hypersomnia
- Insomnia (correct)
- Hyperphagia
Which structure connects the mammillary body to the anterior nucleus of the thalamus?
Which structure connects the mammillary body to the anterior nucleus of the thalamus?
- Cingulate gyrus
- Mammillothalamic tract (correct)
- Tegmental fibers
- Mammillotegmental tract
What effect does a lesion in the ventromedial nucleus of the hypothalamus typically produce?
What effect does a lesion in the ventromedial nucleus of the hypothalamus typically produce?
- Diabetes insipidus
- Hypophagia
- Rage
- Hyperphagia (correct)
Which type of fibers arise from the midbrain and are connected to the hypothalamus?
Which type of fibers arise from the midbrain and are connected to the hypothalamus?
What is the primary function of the hypothalamus in relation to melatonin production?
What is the primary function of the hypothalamus in relation to melatonin production?
What is a significant function of the basolateral amygdala?
What is a significant function of the basolateral amygdala?
Which structure is specifically involved in processing olfactory signals?
Which structure is specifically involved in processing olfactory signals?
Which subdivision of the amygdala is primarily involved in autonomic and endocrine behavior?
Which subdivision of the amygdala is primarily involved in autonomic and endocrine behavior?
What structure connects the hippocampus to the hypothalamus?
What structure connects the hippocampus to the hypothalamus?
Which anatomical structure is noted for being involved in a tri-synaptic circuit crucial for memory?
Which anatomical structure is noted for being involved in a tri-synaptic circuit crucial for memory?
What is the role of the centromedial amygdala in the brain?
What is the role of the centromedial amygdala in the brain?
What might a larger hippocampus in lower order mammals indicate?
What might a larger hippocampus in lower order mammals indicate?
Which is NOT a subdivision of the amygdala?
Which is NOT a subdivision of the amygdala?
What is the primary role of the hypothalamus?
What is the primary role of the hypothalamus?
Which part of the hypothalamus is associated with the mammillary bodies?
Which part of the hypothalamus is associated with the mammillary bodies?
Which mechanism in the hypothalamus is specifically involved in stress reactions?
Which mechanism in the hypothalamus is specifically involved in stress reactions?
Which of the following is NOT a function of the hypothalamus?
Which of the following is NOT a function of the hypothalamus?
What type of inputs predominantly reach the hypothalamus through the tractus solitarius?
What type of inputs predominantly reach the hypothalamus through the tractus solitarius?
Which of the following best describes the olfactory system's unique feature?
Which of the following best describes the olfactory system's unique feature?
The primary regulatory function of the hippocampus is mainly linked to which system?
The primary regulatory function of the hippocampus is mainly linked to which system?
What is the main output pathway of the limbic system considered to be?
What is the main output pathway of the limbic system considered to be?
What neurotransmitters are primarily used by inhibitory cells?
What neurotransmitters are primarily used by inhibitory cells?
What is the main role of glomeruli in the olfactory bulb?
What is the main role of glomeruli in the olfactory bulb?
Which statement about the olfactory system in humans is accurate?
Which statement about the olfactory system in humans is accurate?
How does olfaction differ between humans and other animals?
How does olfaction differ between humans and other animals?
Where does the primary olfactory cortex lie?
Where does the primary olfactory cortex lie?
What is the role of the amygdala in relation to olfaction?
What is the role of the amygdala in relation to olfaction?
What is a characteristic of the olfactory bulb in mammals?
What is a characteristic of the olfactory bulb in mammals?
Which of these behaviors is NOT influenced by olfaction in humans?
Which of these behaviors is NOT influenced by olfaction in humans?
Which structure is NOT part of the original components of the Papez circuit?
Which structure is NOT part of the original components of the Papez circuit?
What is the primary function of the amygdala within the limbic system?
What is the primary function of the amygdala within the limbic system?
Which region is responsible for the formation of new neurons, or neurogenesis, in adults?
Which region is responsible for the formation of new neurons, or neurogenesis, in adults?
The cingulate cortex is part of which major brain system?
The cingulate cortex is part of which major brain system?
Which division of the hypothalamus is involved in regulating the body's homeostasis?
Which division of the hypothalamus is involved in regulating the body's homeostasis?
What is the significance of the interthalamic adhesion within the limbic system?
What is the significance of the interthalamic adhesion within the limbic system?
Which of the following structures is directly linked to learning and memory?
Which of the following structures is directly linked to learning and memory?
Which statement is true regarding the sense of smell in adult humans?
Which statement is true regarding the sense of smell in adult humans?
What is the primary role of olfactory receptor neurons?
What is the primary role of olfactory receptor neurons?
Which cranial nerve is primarily associated with the sense of smell?
Which cranial nerve is primarily associated with the sense of smell?
What is the function of periglomerular cells in the olfactory system?
What is the function of periglomerular cells in the olfactory system?
How are olfactory neurons organized in relation to their receptors?
How are olfactory neurons organized in relation to their receptors?
What role do granule cells play in the olfactory system?
What role do granule cells play in the olfactory system?
What characterizes the relationship between the neurons and glomeruli in the olfactory bulb?
What characterizes the relationship between the neurons and glomeruli in the olfactory bulb?
How does the sense of smell impact interpersonal communication?
How does the sense of smell impact interpersonal communication?
What happens when an odorant binds to its receptor in the olfactory system?
What happens when an odorant binds to its receptor in the olfactory system?
Flashcards
Descending fibers from the hypothalamus
Descending fibers from the hypothalamus
These fibers connect the hypothalamus to the brainstem and spinal cord, regulating autonomic functions like heart rate, blood pressure, and digestion.
Mammillothalamic tract
Mammillothalamic tract
These fibers connect the hypothalamus to the anterior nucleus of the thalamus, involved in memory and emotional processing.
Mammillotegmental tract
Mammillotegmental tract
These fibers connect the hypothalamus to the reticular formation in the midbrain, involved in controlling alertness and sleep-wake cycles.
Anterior hypothalamus lesion
Anterior hypothalamus lesion
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Lateral hypothalamus lesion
Lateral hypothalamus lesion
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Smell and memory
Smell and memory
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Smell and communication
Smell and communication
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Odorant receptors
Odorant receptors
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Glomeruli in olfactory bulb
Glomeruli in olfactory bulb
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Mitral and tufted cells
Mitral and tufted cells
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Inhibitory neurons in olfactory bulb
Inhibitory neurons in olfactory bulb
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Olfactory receptor neurons
Olfactory receptor neurons
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Olfactory signal processing
Olfactory signal processing
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Limbic System
Limbic System
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Papez Circuit
Papez Circuit
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Hypothalamus
Hypothalamus
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Hippocampus
Hippocampus
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Amygdala
Amygdala
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Neurogenesis
Neurogenesis
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Olfactory Bulb
Olfactory Bulb
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Cingulate Cortex
Cingulate Cortex
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Hypothalamus Divisions
Hypothalamus Divisions
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Mammillary Body
Mammillary Body
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Hypothalamic-Pituitary-Adrenal (HPA) Axis
Hypothalamic-Pituitary-Adrenal (HPA) Axis
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Hypothalamic Nuclei
Hypothalamic Nuclei
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Cingulum
Cingulum
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Corticohypothalamic Fibers
Corticohypothalamic Fibers
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Hippocampo-hypothalamic Fibers
Hippocampo-hypothalamic Fibers
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Inhibitory neurotransmitters
Inhibitory neurotransmitters
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Glomerular layer
Glomerular layer
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Human olfactory system
Human olfactory system
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Primary olfactory cortex
Primary olfactory cortex
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Olfactory bulb connections
Olfactory bulb connections
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Humans vs animals - olfaction
Humans vs animals - olfaction
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Basolateral Amygdala
Basolateral Amygdala
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Olfactory Amygdala
Olfactory Amygdala
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Centromedial Amygdala
Centromedial Amygdala
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Extended Amygdala
Extended Amygdala
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Fornix
Fornix
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Hippocampus Formation
Hippocampus Formation
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Tri-synaptic Circuit of the Hippocampus
Tri-synaptic Circuit of the Hippocampus
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Study Notes
Learning Objectives: The Limbic System
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The limbic system encompasses structures involved in emotion, motivation, memory, and olfaction
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Components include the limbic lobe, Papez circuit, and various structures like amygdala, hippocampus and hypothalamus.
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The limbic structures play a role in emotional response and experience, not just simple stimulus/responses
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The Papez circuit, a crucial circuit in the limbic system, has components like the hypothalamus, thalamus, and cingulate cortex; it is important for processing information for emotions
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Olfactory system anatomy and connections to limbic structures are vital to understanding sensory/emotional links.
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The amygdala is subdivided and has various connections, playing roles in emotions and memories, including fear.
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The hippocampus is composed of three subdivisions; it's critical for memory consolidation and spatial navigation and plays a role in the formation of new long-term memories
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Hypothalamus' three subdivisions (anterior, middle, and posterior) each have unique functions in regulating homeostasis and various body processes, such as temperature regulation, hunger, thirst, and endocrine function
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Connectivity between hypothalamic regions and other limbic structures is complex; it includes afferent and efferent connections.
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The mammillary bodies' connections with other structures like the hippocampus are important for memory storage, recalling prior experiences and connecting past memories to current situations
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Visualization of limbic structures in brain sections enables understanding of their spatial relationship and anatomical features
Case Study: Patient HM
- Patient HM's temporal lobe epilepsy led to the surgical removal of the amygdala and hippocampus
- The resulting damage provided critical insights into the function of the limbic system in learning, memory, and potentially other cognitive processes.
Circuit of Papez (1939)
- Key components include: hypothalamus, anterior nucleus of thalamus, and cingulate cortex;
- They collectively play various roles in emotional processing, memory encoding and retrieval, and relating past information to present circumstances
Missing Parts
- The circuit of Papez and its parts, especially the hypothalamus and its parts, are essential to the processing and storage of emotional events
Hippocampus → Hypothalamus Connections
- Fibers pass through the Fornix to the hypothalamus and to the stria terminalis to further connect with the hypothalamus via synapses
Limbic Structures
- Cingulate gyrus -- a gyrus that leads to the hypothalamus and hippocampus, and the fornix
- Hippocampal formation part of limbic system
- Amygdala
- Hypothalamus
Olfaction and the Sense of Smell
- Olfactory neurons in the nasal cavity process and transmit smell signals via their axons.
- The sense of smell connects strongly to memories, because the two systems are highly interwoven.
- Smell receptors process chemical substances that are carried in the air causing smells.
Cranial Nerves and the Five Senses
- Cranial nerves oversee distinct sensory functions
Olfactory Signal Initiation and Transmission
- Odor molecules bind to specific receptors and signal transmission happens; results in specific glomeruli activation across the olfactory system; a specific smell gets processed in distinct regions to understand the smell;
Connections of olfactory neurons in mammals
- Olfactory neuron axons terminate at glomeruli in the olfactory
- Bulb, which then projects further for processing.
Humans vs Mammals; Olfactory System
- Human's olfactory system is only partially developed
- Have some similarities to certain animals' olfactory systems
Amygdala
- The amygdala is an almond-shaped structure in the brain, involved in processing emotions, fear conditioning, emotional memories,
- Four major subdivisions (basolateral, olfactory, centromedial, stria terminalis nuclei).
The Hypothalamus
- The hypothalamus plays a critical role in maintaining homeostasis
- It regulates many vital bodily functions, such as body temperature, sleep-wake cycles, and hormone release
- Three subdivisions (anterior, middle, posterior) of the hypothalamus; each controls distinct functions.
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