Pseudopolymorphic Solvates in Pharmacy
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Questions and Answers

Which type of crystal solvate is stable and difficult to desolvate because the solvent plays a key role in holding the crystal together?

  • Polymorphic solvate (correct)
  • Anhydrate
  • Monohydrate
  • Pseudopolymorphic solvate
  • What term is used to describe crystals that contain solvent of crystallization?

  • Hydrate (correct)
  • Monohydrate
  • Anhydrate
  • Pseudopolymorphic solvate
  • If a crystal loses its solvent and recrystallizes in a new form, it is likely a:

  • Pseudopolymorphic solvate (correct)
  • Monohydrate
  • Hydrate
  • Anhydrate
  • What is the term for a crystal that does not contain any water within its structure?

    <p>Anhydrate</p> Signup and view all the answers

    Which type of crystal solvate typically has a complex dissolution rate due to its structure and composition?

    <p>Pseudopolymorphic solvate</p> Signup and view all the answers

    What happens to pseudopolymorphic solvates when desolvation occurs?

    <p>Their crystal lattice remains intact</p> Signup and view all the answers

    How do the physicochemical properties of solvated forms differ from anhydrous forms?

    <p>Anhydrous forms have higher melting points</p> Signup and view all the answers

    What is typically true about the melting point comparison between anhydrous crystals and hydrates?

    <p>The melting point of anhydrous crystals is usually higher</p> Signup and view all the answers

    How does the dissolution rate of hydrates compared to anhydrous forms vary?

    <p>The dissolution rate can vary depending on the hydrate structure</p> Signup and view all the answers

    Why can some hydrates have a slower dissolution rate than anhydrous forms?

    <p>Water in hydrates can hydrogen bond between drug molecules, giving a more stable lattice</p> Signup and view all the answers

    What is the main purpose of pharmaceutical co-crystals?

    <p>To alter drug properties like solubility or hygroscopicity</p> Signup and view all the answers

    Which type of polymorph can be reversibly changed to another form by varying temperature and pressure?

    <p>Enantiotropic</p> Signup and view all the answers

    What type of polymorph undergoes irreversible change between two forms?

    <p>Monotropic</p> Signup and view all the answers

    Which polymorphic form is selected for solid dosage forms during drug development?

    <p>The most stable form</p> Signup and view all the answers

    What type of polymorph has the highest melting temperature and is the least soluble in any solvent?

    <p>Stable polymorphic form</p> Signup and view all the answers

    Which type of crystal habit may make it difficult to inject a polymorph in suspension form or formulate it as a tablet?

    <p>Certain crystal habits</p> Signup and view all the answers

    What can crystal growth in creams as a result of phase transformation cause to happen?

    <p>The cream to become gritty</p> Signup and view all the answers

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