Protein Synthesis and Degradation Regulation
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Questions and Answers

What is the primary mechanism of controlling protein concentration in the cell for many proteins?

  • Regulation of protein synthesis (correct)
  • Modulation of protein localization
  • Regulation of protein degradation
  • Selective inhibition of protein translation

What is the process called that leads to the hydrolysis and resynthesis of 300 to 400 g of body protein each day?

  • Protein synthesis
  • Protein modification
  • Protein degradation
  • Protein turnover (correct)

What is the measure of a protein's relative susceptibility to degradation?

  • Protein concentration
  • Protein activity
  • Half-life (correct)
  • Protein localization

What is the typical half-life range of liver proteins?

<p>30 minutes to 150 hours (D)</p> Signup and view all the answers

Which type of proteins have half-lives measured in minutes or hours?

<p>Short-lived proteins (B)</p> Signup and view all the answers

What is the typical half-life of 'housekeeping' enzymes, such as those of glycolysis?

<p>Over 100 hours (B)</p> Signup and view all the answers

What is the characteristic of structural proteins like collagen?

<p>They have t½ values measured in months or years (D)</p> Signup and view all the answers

What is the function of the ATP-dependent ubiquitin-proteasome system?

<p>To selectively degrade short-lived, misfolded, or damaged proteins (C)</p> Signup and view all the answers

What is the purpose of ubiquitylation in the ubiquitin-proteasome system?

<p>To mark proteins for degradation (D)</p> Signup and view all the answers

What is the result of the consecutive addition of four or more Ub molecules to a target protein?

<p>The formation of a polyubiquitin chain (B)</p> Signup and view all the answers

What is the role of E3 proteins in the ubiquitin-proteasome system?

<p>To identify proteins to be degraded (C)</p> Signup and view all the answers

What is the unique characteristic of the ubiquitin-proteasome system compared to simple hydrolysis by proteolytic enzymes?

<p>It requires ATP hydrolysis (A)</p> Signup and view all the answers

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