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Protein Synthesis and Degradation Regulation

12 Questions

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Protein Synthesis and Degradation Regulation

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Questions and Answers

What is the primary mechanism of controlling protein concentration in the cell for many proteins?

Regulation of protein synthesis (correct)

Modulation of protein localization

Regulation of protein degradation

Selective inhibition of protein translation

What is the process called that leads to the hydrolysis and resynthesis of 300 to 400 g of body protein each day?

Protein synthesis

Protein modification

Protein degradation

Protein turnover (correct)

What is the measure of a protein's relative susceptibility to degradation?

Protein concentration

Protein activity

Half-life (correct)

Protein localization

What is the typical half-life range of liver proteins?

30 minutes to 150 hours Signup and view all the answers

Which type of proteins have half-lives measured in minutes or hours?

Short-lived proteins Signup and view all the answers

What is the typical half-life of 'housekeeping' enzymes, such as those of glycolysis?

Over 100 hours Signup and view all the answers

What is the characteristic of structural proteins like collagen?

They have t½ values measured in months or years Signup and view all the answers

What is the function of the ATP-dependent ubiquitin-proteasome system?

To selectively degrade short-lived, misfolded, or damaged proteins Signup and view all the answers

What is the purpose of ubiquitylation in the ubiquitin-proteasome system?

To mark proteins for degradation Signup and view all the answers

What is the result of the consecutive addition of four or more Ub molecules to a target protein?

The formation of a polyubiquitin chain Signup and view all the answers

What is the role of E3 proteins in the ubiquitin-proteasome system?

To identify proteins to be degraded Signup and view all the answers

What is the unique characteristic of the ubiquitin-proteasome system compared to simple hydrolysis by proteolytic enzymes?

It requires ATP hydrolysis Signup and view all the answers